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Lara Lange, MD

University of Lübeck and University Medical Center Schleswig-Holstein

Bethesda, MD, USA

Working Groups

Area of Focus

  • Movement Disorders
  • Neurogenetics
  • Neurology

Biography

Lara is a medical doctor and postdoctoral fellow at the Laboratories of Neurogenetics, NIH/NIA in Bethesda, MD, United States. She went to medical school in Luebeck, Germany and was trained as a clinician scientist at the Institute of Neurogenetics in Luebeck. She focuses her research on the clinical and molecular genetics of movement disorders. She is a member of the Monogenic Network within GP2 and co-lead of GP2’s Monogenic Data Analysis working group. ​

Contact

[email protected]

Outputs and publications by Lara Lange, MD

Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)
The Monogenic Network of the Global Parkinson’s Genetics Program (GP2) aims to create an efficient infrastructure to accelerate the identification of novel genetic causes of Parkinson’s disease (PD) and to improve our understanding of already identified genetic causes, such as reduced penetrance and variable clinical expressivity of known disease-causing variants. We aim to perform short- and long-read whole-genome sequencing for up to 10,000 patients with parkinsonism. Important features of this project are global involvement and focusing on historically underrepresented populations.
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The LRRK2 p.L1795F variant causes Parkinson's disease in the European population
We identified the LRRK2 p.L1795F variant in 14 White/European ancestry PD patients, including two families with multiple affected carriers and seven additional affected individuals with familial PD using genotyping and sequencing data from more than 50,000 individuals through GP2, AMP-PD, PDGENEration, and CENTOGENE.
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Team Science Approaches to Unravel Monogenic Parkinson's Disease on a Global Scale
In this article, we describe combining both efforts in a merger project resulting in a global monogenic PD cohort with the buildup of a sustainable infrastructure to identify the multi-ancestry spectrum of monogenic PD and enable studies of factors modifying penetrance and expressivity of monogenic PD.
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