Prodromal Working Group

Our aim is to bring together clinical information and biosamples from over 20,000 individuals with prodromal PD or individuals who are ‘at-risk’, and unaffected individuals collected in the same cohorts which can be used for comparison. This effort is bringing data and samples from established cohorts, whilst also supporting new collections or expanding existing collections, particularly in regions of the world where there has not been a focus on prodromal disease.

We are particularly interested in bringing in data from:

Individuals with rapid eye movement (REM) sleep behaviour disorder (RBD)
Individuals with hyposmia (reduced sense of smell)
Individuals without disease who carry genetic variants in PD genes of interest (LRRK2, GBA1) or potentially have high genetic risk
Individuals who have had alpha-synuclein amplification assay (SAA) testing
Individuals with pure autonomic failure
Individuals identified by a combination of risk factors, such as MDS prodromal criteria or the PREDICT-PD algorithm

We will put together the genetic and clinical information from these individuals and cohorts to enable analyses in the field of prodromal, at-risk, and early PD. For example, we hope to better understand the genetic factors that influence RBD and hyposmia, and which factors influence whether someone will develop PD or other synucleinopathies.