Monogenic – Data Analysis Working Group
About the Monogenic – Data Analysis Working Group
The Data Analysis group is one of the three working groups making up the Monogenic Network. This Working Group executes and coordinates core analyses to identify the genetic basis of monogenic forms of Parkinson’s disease in close collaboration with the sample providers.
We will analyze genotyping and whole genome sequencing data obtained from the collected families in close collaboration with the sample providers. We hope to be able to analyze samples from across the world and include patients from underrepresented populations. We will also develop population specific reference genomes that will improve the detection of population specific risk factors.
Milestones
Active
- Analysis strategies for monogenic data
- The bioinformatic workflow for identifying known and novel repeat expansions
- The bioinformatic workflow for structural variant joint calling
- Rare-variant association analyses (coding and non-coding variants)
Completed
- The family-based whole-genome data analysis workflows
Not Started
- The anaylses of Mitochondrial DNA variants