Underrepresented Populations Working Group
About the Underrepresented Populations Working Group
Lack of diversity is one of the critical challenges that the genetics field must overcome. To date, approximately 80% of all genome-wide association studies (GWASs) have been conducted in non-Hispanic Europeans. For example, Asians constitute 60% of the world population, but are represented only in 10% of the samples investigated. Latinos represent less than 0.5%, and for Africans, the number is even lower. These differences limit our insights into disease mechanisms and, importantly, create inequalities when newer diagnostic and therapeutic approaches are developed based on genetic information.
Our mission is to join forces to increase representation and decipher the genetic factors associated with Parkinson’s disease (PD) in non-European populations. We will promote recruitment of persons with PD and ethnically matched healthy controls from underrepresented populations. To add to the Monogenic working group’s efforts, we will identify multiplex families from underrepresented populations, and together with the Data Analysis working group we will help develop the analysis tools necessary to deal with our different and complex genetic admixture. We aim to build resources in the participating countries, including physical resources such as biobanks and training opportunities for local junior researchers. Alongside this we will include researchers, especially junior, to be actively involved in all analyses.
Milestones
Completed
- Published an article about underrepresented populations in PD genetics research
Active
- Conduct first multi-ancestry genome-wide meta-analysis in PD
- Increasing URP data collection efforts
- Preliminary GWAS analysis in East Asia and Africa
- Supporting training opportunities to researchers from URPs and engaging with trainee network
- Identify barriers to genetic testing in countries with predominantly underrepresented populations
- Encourage URP researchers to submit project analysis proposals to GP2
- Support underrepresented research groups in recruitment and analysis
- Identify and engage with new URP sites that are not currently represented in GP2
Not Started
- Conduct a survey about unprofessional peer review and barriers to publish