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Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

May 15, 2023

Sample Prioritization Working Group

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The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

Sample Prioritization Working Group

The Sample Prioritization working group prioritizes samples based on the input from the monogenic portal.
Learn more about Sample Prioritization Working Group

Meet the authors

Clinician Scientist

Lara M. Lange, MD

University of Lübeck and University Medical Center Schleswig-Holstein | Lübeck, Germany

Assistant Professor of Neurology, Neurologist

Micol Avenali, MD, PhD

University of Pavia, Fondazione Istituto Neurologico Nazionale Casimiro Mondino | Pavia, Italy

PhD student

Anastasia Illarionova, BSc

Deutsches Zentrum für Neurodegenerative Erkrankungen | Germany

Postdoc

Ignacio Juan Keller Sarmiento, MD

Northwestern University | USA

Associate Professor and Consultant Neurologist

Ai Huey Tan, MD

University of Malaya | Malaysia

Member

Harutyun Madoev

University of Luebeck | Germany

Member

Johanna Junker, MD

University of Luebeck | Luebeck, Germany

Associate Professor

Roopa Rajan

All India Institute of Medical Sciences | India

Member, Senior Associate Director

J C. Solle

The Michael J. Fox Foundation for Parkinson's Research, The Michael J. Fox Foundation for Parkinson's Research | USA

Member, Research Assistant

Simona Jasaityte, MSc

University College London, University College London | UK

Member, Research Assistant

Simona Jasaityte, MSc

University College London, University College London | UK

Member, Research Assistant

Simona Jasaityte, MSc

University College London, University College London | UK

Member, Research Assistant

Simona Jasaityte, MSc

University College London, University College London | UK

More outputs and publications

Workflows of Data and Samples
The following document outlines the workflow of the data and samples from contributing cohorts with existing DNA, and contributing cohorts with existing or externally generated genotype data.
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NIA-Material Transfer Agreement
The material transfer agreement for the transfer of human materials for research purposes is outlined in the following document.
Read More
Sample Prioritization Table
The Monogenic Network of GP2 is prioritizing cases where a monogenic cause of Parkinson’s disease is strongly suspected. Multiple factors will be considered and scoring criteria will be used.
Read More