1. Back to Outputs Catalog

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

May 15, 2023

Cohort Integration Working Group

View Article

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.

Cohort Integration Working Group

The Cohort Integration working group assembles clinical and genetic data from new and existing cohorts for analysis to understand risk factor genes.
Learn more about Cohort Integration Working Group

Meet the authors

Unknown, Research Assistant

Clodagh Towns

Unknown, UCL | Ireland

Unknown

Madeleine Richer

unknown | UK

Member, Research Assistant

Simona Jasaityte, MSc

University College London, University College London | UK

Member

Eleanor (Ellie) Stafford, MSc

University College London | London, UK

Research Fellow , Research Fellow

Tarek Antar

National Institute of Aging, NIH | USA

PhD Student

Alejandro Martínez-Carrasco, MSc

University College London | London, UK

Biomedical Data Scientist, Contractor

Mary B Makarious, PhD

National Institutes of Health | Washington D.C., USA

Senior Associate Director

Bradford Casey, PhD

The Michael J Fox Foundation for Parkinson's Research | New York City, NY, USA

Data Scientist

Dan Vitale

National Institutes of Health | USA

More outputs and publications

Towards a Global View of Parkinson's Disease Genetics
Description Parkinson\’s disease (PD) is a global health challenge, yet historically studies of PD have taken place predominantly in European populations. Recent genetics research conducted in non-European populations has revealed novel population-specific genetic loci linked to PD risk, highlighting the importance of studying PD globally. These insights have broadened our understanding of PD etiology, which […]
Read More
Mendelian Randomization and Parkinson's Disease
Description Integrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinson\’s disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson’s disease and other forms of parkinsonism. The book traces the evolution of omics technologies from the discovery of […]
Read More
Is SH3GL2 p.G276V the Causal Functional Variant Underlying Parkinson's Disease Risk at this Locus?
We read with great interest the article by Bademosi and colleagues, where they investigated the role of SH3GL2 p.G276V on neuron dysfunction in Parkinson's disease (PD).
Read More