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Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)

July 31, 2023

Sample Prioritization Working Group

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The Monogenic Network of the Global Parkinson’s Genetics Program (GP2) aims to create an efficient infrastructure to accelerate the identification of novel genetic causes of Parkinson’s disease (PD) and to improve our understanding of already identified genetic causes, such as reduced penetrance and variable clinical expressivity of known disease-causing variants. We aim to perform short- and long-read whole-genome sequencing for up to 10,000 patients with parkinsonism. Important features of this project are global involvement and focusing on historically underrepresented populations.

Sample Prioritization Working Group

The Sample Prioritization working group prioritizes samples based on the input from the monogenic portal.
Learn more about Sample Prioritization Working Group

Meet the authors

Clinician Scientist

Lara M. Lange, MD

University of Lübeck and University Medical Center Schleswig-Holstein | Lübeck, Germany

Assistant Professor of Neurology, Neurologist

Micol Avenali, MD, PhD

University of Pavia, Fondazione Istituto Neurologico Nazionale Casimiro Mondino | Pavia, Italy

PhD student

Anastasia Illarionova, BSc

Deutsches Zentrum für Neurodegenerative Erkrankungen | Germany

Postdoc

Ignacio Juan Keller Sarmiento, MD

Northwestern University | USA

Associate Professor and Consultant Neurologist

Ai Huey Tan, MD

University of Malaya | Malaysia

Member

Harutyun Madoev

University of Luebeck | Germany

Data Manager

Caterina Galandra, PhD

IRCCS Mondino Foundation | Italy

Member

Johanna Junker, MD

University of Luebeck | Luebeck, Germany

Associate Professor

Roopa Rajan

All India Institute of Medical Sciences | India

Member, Senior Associate Director

J C. Solle

The Michael J. Fox Foundation for Parkinson's Research, The Michael J. Fox Foundation for Parkinson's Research | USA

Pre-doctoral Intramural Research Training Awardee

Mary B Makarious, BSc

Laboratories of Neurogenetics, University of Lübeck | USA

Pre-doctoral Intramural Research Training Awardee

Mary B Makarious, BSc

Laboratories of Neurogenetics, University of Lübeck | USA

More outputs and publications

Workflows of Data and Samples
The following document outlines the workflow of the data and samples from contributing cohorts with existing DNA, and contributing cohorts with existing or externally generated genotype data.
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NIA-Material Transfer Agreement
The material transfer agreement for the transfer of human materials for research purposes is outlined in the following document.
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Sample Prioritization Table
The Monogenic Network of GP2 is prioritizing cases where a monogenic cause of Parkinson’s disease is strongly suspected. Multiple factors will be considered and scoring criteria will be used.
Read More