Pablo Mir

Our group focuses its research on three main areas:

1. Study of genetic factors involved in the pathogenesis of Parkinson´s disease (PD) and other movement disorders.In the last few years numerous genes related to the pathophysiology of movement disorders have been described. Our group is interested in the characterisation of these genes, as well as of other possible candidate genes. Our final objective is to investigate the functional consequences of the alterations of these genes in our population by means of the phenotype-genotype correlation analysis and studies of genetic linkage.

2. Transcraneal magnetic stimulation (TMS) in the study of the pathophysiology of PD and other movement disorders.In this line our group attempts to evaluate, using TMS, the role of various areas of the brain in the pathophysiology of PD and other movement disorders, as well as their modulation by drugs, functional surgery and genetic factors.

3. Studies of the clinical aspects of PD and other movement disorders.The objective of this line is focussed on the more clinical aspects of movement disorders, describing unusual presentations of different diseases and differential clinical characteristics of some entities. The study of the efficacy of various therapies is also included, as well as the diagnostic value of different neuroimaging tests in PD and other movement disorders.