Ryan Dhindsa, MD, PhD

• Data Science
• Burden analysis
• ITSN1
• Genetics of Parkinson’s
• Functional genomics
• Modifiers
• Monogenic
• scRNA-seq
• Whole genome sequencing

Ryan is a tenure-track Assistant Professor in the Department of Pathology and Immunology at Baylor College of Medicine, a Principal Investigator at the Duncan Neurological Research Institute, and a faculty member of the Division of Genomic Medicine & Discovery at Texas Children’s Hospital. He also serves as co-director of the Texas Children’s Better Together Biobank and is a recipient of the NIH Director’s Early Independence Award.

His research program focuses on how genomic variation influences human health, with a particular emphasis on neurological disorders. His laboratory integrates population genetics, multi-omics (genomics, transcriptomics, proteomics), and human stem cell–based functional genomics to dissect the mechanisms of complex diseases and identify new therapeutic targets. His group has led the analysis of hundreds of thousands of human genomes, uncovering an outsized role of rare variants in human disease and discovering new risk genes for Parkinson’s disease (ITSN1), epilepsy, idiopathic pulmonary fibrosis, and diabetes.

In parallel, his team develops novel statistical and machine learning methods to improve the interpretation of genetic variation. These computational discoveries are coupled with CRISPR-based functional genomics screens in stem cell–derived neurons, enabling large-scale mapping of key molecular and cellular events in neurodevelopmental and neurodegenerative diseases. Through broad collaborations with academic and industry partners, Dr. Dhindsa’s program is translating these discoveries into targeted therapies and advancing precision medicine.