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Gist Croft, PhD

Garvan Institute of Medical Research

NY, USA

Area of Focus

  • GBA1
  • LRRK2
  • SNCA
  • Heterogeneity
  • Biomarker
  • Functional genomics
  • Neuroinflammation
  • Laboratory Science
  • Lysosomes

Biography

Gist has been developing human stem cell models of neurodegenerative diseases since 2024, including ALS, Huntington’s, Alzheimer’s, and, for the past 8 years, Parkinson’s disease. He uses developmental biology to generate specific affected cell types and tissue (organoid) models, developing functional assays, and using patient genetics to define disease mechanisms and therapeutic targets. His labs recent work focuses on using large patient cohort models to understand disease heterogeneity, complex glial-neuronal cultures to understand the neuroinflammation, SNCA aggregation and traficking in PD, and live cell biological imaging.