{"id":50012100,"date":"2024-01-18T18:21:59","date_gmt":"2024-01-18T23:21:59","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/%e9%92%88%e5%af%b9%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e7%9a%84%e8%b7%a8%e7%a5%96%e6%ba%90%e5%85%a8%e5%9f%ba%e5%9b%a0%e7%bb%84%e5%85%b3%e8%81%94%e7%a0%94%e7%a9%b6%ef%bc%88gwas%ef%bc%89\/"},"modified":"2024-10-21T15:49:51","modified_gmt":"2024-10-21T19:49:51","slug":"%e9%92%88%e5%af%b9%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e7%9a%84%e8%b7%a8%e7%a5%96%e6%ba%90%e5%85%a8%e5%9f%ba%e5%9b%a0%e7%bb%84%e5%85%b3%e8%81%94%e7%a0%94%e7%a9%b6%ef%bc%88gwas%ef%bc%89","status":"publish","type":"post","link":"https:\/\/gp2.org\/zh-hans\/%e9%92%88%e5%af%b9%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e7%9a%84%e8%b7%a8%e7%a5%96%e6%ba%90%e5%85%a8%e5%9f%ba%e5%9b%a0%e7%bb%84%e5%85%b3%e8%81%94%e7%a0%94%e7%a9%b6%ef%bc%88gwas%ef%bc%89\/","title":{"rendered":"\u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u7684\u8de8\u7956\u6e90\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09"},"content":{"rendered":"<p><span data-contrast=\"auto\">\u5e15\u91d1\u68ee\u75c5(PD)\u4e00\u76f4\u662f\u9057\u4f20\u5b66\u7814\u7a76\u7684\u70ed\u70b9\u3002\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u786e\u5b9a\u4e8690\u591a\u79cd\u53ef\u80fd\u5f71\u54cd\u4e2a\u4eba\u60a3\u5e15\u91d1\u68ee\u75c5\u98ce\u9669\u7684\u57fa\u56e0\u53d8\u5f02\uff0c\u63ed\u793a\u4e86\u8fd9\u662f\u4e00\u79cd\u6d89\u53ca\u8bb8\u591a\u5206\u5b50\u901a\u8def\u7684\u590d\u6742\u75be\u75c5\u3002\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u7136\u800c\uff0c\u7531\u4e8e\u5bf9\u5e15\u91d1\u68ee\u75c5\u7684\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u6b27\u6d32\u8840\u7edf\u7684\u4eba\u7fa4\uff0c\u7f3a\u4e4f\u9057\u4f20\u591a\u6837\u6027\uff0c\u59a8\u788d\u4e86\u6211\u4eec\u5bf9\u5e15\u91d1\u68ee\u75c5\u7684\u5168\u9762\u6027\u3001\u5168\u7403\u6027\u4e86\u89e3\u3002\u54ea\u4e9bPD\u9057\u4f20\u53d8\u5f02\u66f4\u6709\u53ef\u80fd\u662f\u8bf1\u56e0\uff1f\u54ea\u4e9b\u5728\u4e0d\u540c\u4eba\u7fa4\u4e2d\u7684\u53d8\u5f02\u53ef\u80fd\u5bf9\u4e34\u5e8a\u6709\u7528\uff1f\u8981\u56de\u7b54\u8fd9\u4e9b\u95ee\u9898\uff0c\u9700\u8981\u66f4\u591a\u6765\u81ea\u4e0d\u540c\u7956\u6e90\u6570\u636e\u3002<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">\u5168\u7403\u5408\u4f5c\uff1a\u591a\u7956\u6e90\u7814\u7a76\u548c\u5e9e\u5927\u7684\u89c4\u6a21<\/span><\/b> <span data-contrast=\"auto\"><br \/>\n<\/span><a href=\"https:\/\/www.nature.com\/articles\/s41588-023-01584-8\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">\u53d1\u8868\u5728<em>\u300a\u81ea\u7136-\u9057\u4f20\u5b66\u300b\uff08Nature Genetics\uff09<\/em><\/span><\/a><span data-contrast=\"auto\">\u00a0\u6742\u5fd7\u4e0a\u7684\u4e00\u9879\u65b0\u8054\u5408\u7814\u7a76\u63d0\u4f9b\u4e86\u5bf9\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u60c5\u51b5\u7684\u66f4\u7efc\u5408\u3001\u5168\u9762\u7684\u4e86\u89e3\u3002\u8fd9\u9879\u7814\u7a76\u662f\u540c\u7c7b\u7814\u7a76\u4e2d\u89c4\u6a21\u6700\u5927\u3001\u6700\u5177\u591a\u6837\u6027\u7684\uff0c\u8fd9\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u8981\u5f97\u76ca\u4e8e<\/span><a href=\"https:\/\/gp2.org\/zh-hans\/\"><span data-contrast=\"none\">\u5168\u7403\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u5b66\u7814\u7a76\u8ba1\u5212\uff08GP2\uff09<\/span><\/a><span data-contrast=\"auto\">\u7275\u5934\u7684\u5168\u7403\u5408\u4f5c\u548c\u6570\u636e\u5171\u4eab\u5de5\u4f5c\u3002\u8fd9\u9879\u7814\u7a76\u5206\u6790\u4e86 49049 \u540d\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u300118785\u540d\u5176\u7236\u6bcd\u60a3\u6709\u6216\u66fe\u60a3\u6709\u5e15\u91d1\u68ee\u75c5\u7684\u60a3\u8005\uff0c\u4ee5\u53ca 200 \u591a\u4e07\u540d\u5177\u6709\u6b27\u6d32\u3001\u4e1c\u4e9a\u3001\u62c9\u4e01\u7f8e\u6d32\u548c\u975e\u6d32\u8840\u7edf\u7684\u795e\u7ecf\u7cfb\u7edf\u5065\u5eb7\u8005\u7684\u6570\u636e\u3002<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u6765\u81ea\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u3001GP2\u300123andMe \u4ee5\u53ca\u7f8e\u56fd\u3001\u82f1\u56fd\u3001\u79d8\u9c81\u548c\u65b0\u52a0\u5761\u5408\u4f5c\u8005\u7684\u7814\u7a76\u4eba\u5458\u4ece <\/span><a href=\"https:\/\/www.finngen.fi\/en\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">FinnGen<\/span><\/a><span data-contrast=\"auto\">\u3001<a href=\"https:\/\/www.23andme.com\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">23andMe<\/span><\/a><span data-contrast=\"auto\">\u3001<\/span><a href=\"https:\/\/www.ukbiobank.ac.uk\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93\uff08UK Biobank\uff09<\/span><\/a><span data-contrast=\"auto\">\u548c\u5176\u4ed6\u5f00\u653e\u5b58\u53d6\u6570\u636e\u5e93\u4e2d\u6574\u7406\u51fa\u4e86\u8fd9\u4e9b\u591a\u7956\u6e90\u6570\u636e\u3002\u901a\u8fc7\u8fd9\u4e9b\u6570\u636e\uff0c\u4ed6\u4eec\u786e\u5b9a\u4e86\u57fa\u56e0\u7ec4\u4e2d\u4e0ePD\u663e\u8457\u76f8\u5173\u7684 78 \u4e2a\u533a\u57df\uff08&#8221;\u4f4d\u70b9&#8221;\uff09\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span> <\/span><\/p>\n<p><span data-contrast=\"auto\"><span data-contrast=\"auto\">\u8981\u5206\u6790\u6765\u81ea\u591a\u4e2a\u4e0d\u540c\u7956\u6e90\u7684\u6570\u636e\uff0c\u5177\u6709\u72ec\u7279\u7684\u6311\u6218\u6027\uff0c\u4f46\u4e0d\u65ad\u6d8c\u73b0\u7684\u65b0\u8f6f\u4ef6\u548c\u5206\u6790\u5de5\u5177\uff0c\u5c06\u4f7f\u5f97\u65e5\u76ca\u591a\u6837\u5316\u7684\u6570\u636e\u5f97\u4ee5\u6709\u6548\u5229\u7528\u3002\u5f97\u76ca\u4e8e\u8fd9\u4e9b\u5de5\u5177\u548c\u5168\u7403\u8303\u56f4\u5185\u7684\u5408\u4f5c\u52aa\u529b\uff0c\u7814\u7a76\u4eba\u5458\u73b0\u5728\u53ef\u4ee5\u5728\u591a\u7956\u6e90\u4eba\u7fa4\u4e2d\u786e\u5b9a\u4e0ePD\u98ce\u9669\u663e\u8457\u76f8\u5173\u7684\u57fa\u56e0\u533a\u57df\u3002\u8fd9\u4e9b\u533a\u57df\u66f4\u6709\u53ef\u80fd\u5305\u542b\u81f4\u75c5\u53d8\u5f02\u3002<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/span><\/p>\n<p><span data-contrast=\"auto\"><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u4e00\u79cd\u540d\u4e3a\u8de8\u7956\u6e90\u5168\u57fa\u56e0\u7ec4\u5173\u8054(GWAS)\u835f\u8403\u5206\u6790\u7684\u65b9\u6cd5\u3002<\/span><a href=\"https:\/\/www.genome.gov\/genetics-glossary\/Genome-Wide-Association-Studies\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">GWAS<\/span><\/a><span data-contrast=\"auto\">\u662f\u4e00\u79cd\u901a\u8fc7\u68c0\u6d4b\u5927\u91cf\u57fa\u56e0\u7ec4\u800c\u627e\u51fa\u57fa\u56e0\u7ec4\u533a\u57df\uff08&#8221;\u4f4d\u70b9&#8221;\uff09\u4e2d\u7684\u7279\u5b9a\u5e8f\u5217\u53d8\u5f02\u7684\u65b9\u6cd5\uff0c\u8fd9\u4e9b\u53d8\u5f02\u5728\u7279\u5b9a\u75be\u75c5\u60a3\u8005\u7684\u57fa\u56e0\u7ec4\u4e2d\u51fa\u73b0\u7684\u9891\u7387\u8981\u9ad8\u4e8e\u975e\u60a3\u8005\u3002\u7814\u7a76\u4eba\u5458\u4ece\u4ee5\u524d\u53d1\u8868\u7684GWAS\u7814\u7a76\u548c\u4e0d\u540c\u7684\u6570\u636e\u50a8\u5b58\u5e93\u4e2d\u6536\u96c6\u6570\u636e\uff0c\u4ee5\u589e\u52a0\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u98ce\u9669\u56e0\u7d20\u8c03\u67e5\u7684\u7edf\u8ba1\u529f\u6548\u548c\u7a33\u5065\u6027\u3002 \u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span> <\/span><\/p>\n<p><span data-contrast=\"auto\"><span data-contrast=\"auto\">\u901a\u8fc7\u7eb3\u5165\u6765\u81ea\u6b27\u6d32\u4ee5\u5916\u4eba\u7fa4\u7684\u6570\u636e\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u8bb8\u591a\u65b0\u7684\u57fa\u56e0\u4f4d\u70b9\uff0c\u800c\u8fd9\u4e9b\u4f4d\u70b9\u5728\u4e4b\u524d\u4ec5\u7814\u7a76\u6b27\u6d32\u4eba\u7fa4\u65f6\u4e0d\u66fe\u89c2\u5bdf\u5230\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u53d1\u73b0\u768478\u4e2a\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u4f4d\u70b9\u4e2d\uff0c\u5927\u90e8\u5206\u4e0e\u5e15\u91d1\u68ee\u75c5\u76f8\u5173\u533a\u57df\u76f8\u543b\u5408\uff0c\u4f46\u5176\u4e2d12\u4e2a\u53ef\u80fd\u662f\u65b0\u7684\u57fa\u56e0\u4f4d\u70b9\u3002\u8fd9\u4e9b\u65b0\u57fa\u56e0\u4f4d\u70b9\u4f3c\u4e4e\u6d89\u53ca\u5e2e\u52a9\u5206\u89e3\u6216\u4ee3\u8c22\u86cb\u767d\u8d28\u3001\u63a7\u5236\u7ebf\u7c92\u4f53\u6d3b\u52a8\u4ee5\u53ca\u5728\u5927\u8111\u4e2d\u6267\u884c\u514d\u75ab\u53cd\u5e94\u7684\u57fa\u56e0\u3002 \u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/span><\/p>\n<p><span data-contrast=\"auto\"> <span data-contrast=\"auto\">\u5728\u7814\u7a76\u7684\u6240\u6709\u7956\u6e90\u4e2d\uff0c\u5305\u62ec\u6b27\u6d32\u4eba\uff0c\u5927\u591a\u6570\u5df2\u786e\u5b9a\u7684\u57fa\u56e0\u4f4d\u70b9\u90fd\u4e0ePD\u98ce\u9669\u6709\u663e\u8457\u5173\u8054\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u4e0d\u540c\u4eba\u7fa4\u7684\u60a3\u75c5\u9014\u5f84\u53ef\u80fd\u662f\u76f8\u540c\u7684\u3002<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span> <\/span><\/p>\n<p><span data-contrast=\"auto\"><b><span data-contrast=\"auto\">\u8fc8\u5411\u4e2a\u6027\u5316\u533b\u7597\uff1a \u7cbe\u7ec6\u5b9a\u4f4d\u4e0e\u529f\u80fd\u5f71\u54cd<\/span><\/b><br \/>\n<\/span><span data-contrast=\"auto\"><span data-contrast=\"auto\">\u7814\u7a76\u4eba\u5458\u8fd8\u80fd\u5728\u5df2\u8bc6\u522b\u51fa\u7684\u4f4d\u70b9\u4e2d\u627e\u51fa\u81f3\u5c116\u4e2a\u7279\u5b9a\u7684\u81f4\u75c5\u57fa\u56e0\u53d8\u5f02\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u88ab\u79f0\u4e3a\u7cbe\u7ec6\u5b9a\u4f4d\u3002\u7cbe\u7ec6\u5b9a\u4f4d\u53ef\u4ee5\u4f30\u7b97\u51fa\u6bcf\u4e2a\u4f4d\u70b9\u4e2d\u54ea\u4e9b\u7279\u5b9a\u53d8\u5f02\u53ef\u80fd\u4f1a\u5728\u7279\u5b9a\u4eba\u7fa4\u4e2d\u5bfc\u81f4\u75be\u75c5\u98ce\u9669\u3002 <\/span><\/span><\/p>\n<p><span data-contrast=\"auto\"><span data-contrast=\"auto\">\u00a0\u52d2\u7eb3\uff08Lerner\uff09\u7814\u7a76\u6240\u79d1\u5b66\u5bb6\u3001\u514b\u5229\u592b\u5170\u8bca\u6240\u52d2\u7eb3\uff08Lerner\uff09\u533b\u5b66\u9662\u5206\u5b50\u533b\u5b66\u52a9\u7406\u6559\u6388 <\/span><a href=\"https:\/\/www.lerner.ccf.org\/genomic-medicine\/mata\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Ignacio &#8220;Nacho&#8221; Mata<\/span><\/a><span data-contrast=\"auto\"> \u662f\u672c\u7814\u7a76\u7684\u4f5c\u8005\u4e4b\u4e00\uff0c\u4ed6\u8868\u793a\uff1a<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span> <span data-contrast=\"auto\">&#8220;GWAS \u7684\u4e00\u5927\u95ee\u9898\u662f\u4f60\u6c38\u8fdc\u4e0d\u77e5\u9053\u54ea\u4e2a\u7279\u5b9a\u53d8\u5f02\u4f53\u662f\u5df2\u786e\u5b9a\u57fa\u56e0\u4f4d\u70b9\u4e0a\u7684\u529f\u80fd\u53d8\u5f02\u4f53\u6216\u81f4\u75c5\u53d8\u5f02\u4f53\u3002&#8221;\u201c\u5728\u4efb\u4f55\u7279\u5b9a\u7684 GWAS\u2018\u547d\u4e2d&#8217;\u6216\u4e0e\u75be\u75c5\u663e\u8457\u76f8\u5173\u7684\u57fa\u56e0\u7ec4\u533a\u57df\uff0c\u90fd\u53ef\u80fd\u6709\u6570\u767e\u4e2a\u6f5c\u5728\u7684\u5019\u9009\u53d8\u5f02\u4f53\u201d\u3002 \u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><span data-contrast=\"auto\">\u200b<\/span> <\/span><\/p>\n<p><span data-contrast=\"auto\"><span data-contrast=\"auto\">\u786e\u5b9a\u91cd\u8981GWAS\u4f4d\u70b9\u7684\u529f\u80fd\u53d8\u5f02\u53ca\u5176\u5bf9\u57fa\u56e0\u8868\u8fbe\u7684\u5f71\u54cd\u662f\u540e\u7eed\u7814\u7a76\u548c\u5f00\u53d1PD\u9776\u5411\u6cbb\u7597\u836f\u7269\u7684\u5173\u952e\u3002<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span> <\/span><\/p>\n<p><span data-contrast=\"auto\"><span data-contrast=\"auto\">Nacho\u8868\u793a\uff1a\u201c\u901a\u8fc7\u7eb3\u5165\u591a\u7956\u6e90\u6570\u636e\u96c6\uff0c\u6211\u4eec\u80fd\u591f\u7f29\u5c0f\u8bc6\u522b\u51fa\u7684\u4f4d\u70b9\u4e0a\u67d0\u4e9b\u57fa\u56e0\u7684\u529f\u80fd\u53d8\u5f02\u8303\u56f4.\u201d\u201c\u591a\u7956\u6e90\u6570\u636e\u6709\u52a9\u4e8e\u8bc6\u522b\u53ef\u80fd\u5177\u6709\u4eba\u7fa4\u7279\u5f02\u6027\u7684\u53d8\u5f02\uff0c\u4e5f\u6709\u52a9\u4e8e\u8bc6\u522b\u5728\u4e0d\u540c\u4eba\u7fa4\u4e2d\u5177\u6709\u663e\u8457\u6027\u7684\u53d8\u5f02\uff0c\u800c\u8fd9\u4e9b\u53d8\u5f02\u4e5f\u66f4\u6709\u53ef\u80fd\u6210\u4e3a\u91cd\u8981\u7684\u81f4\u75c5\u98ce\u9669\u56e0\u7d20\u201d\u3002 \u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span><\/span><\/p>\n<p><span data-contrast=\"auto\"> <span data-contrast=\"auto\">\u5728\u5df2\u8bc6\u522b\u51fa\u7684\u57fa\u56e0\u4f4d\u70b9\u4e2d\uff0c\u6709\u4e9b\u4f4d\u70b9\u5bf9\u4e0d\u540c\u4eba\u7fa4\u4e2d\u786e\u5b9e\u6709\u4e0d\u540c\u7684\u5f71\u54cd\uff0c\u8fd9\u51f8\u663e\u4e86\u6df1\u5165\u7814\u7a76\u7279\u5b9a\u7956\u6e90\u98ce\u9669\u56e0\u7d20\u7684\u9057\u4f20\u7814\u7a76\u7684\u91cd\u8981\u6027\u3002\u4ec5\u5728\u62c9\u4e01\u7f8e\u6d32\u548c\u975e\u6d32\u4eba\u7fa4\u4e2d\u53d1\u73b0\u7684\u4e24\u4e2a\u57fa\u56e0\u4f4d\u70b9\u4e8e<\/span><i><span data-contrast=\"auto\">JAK1<\/span><\/i><span data-contrast=\"auto\">\u548c<\/span><i><span data-contrast=\"auto\">HS1BP3<\/span><\/i><span data-contrast=\"auto\">\u57fa\u56e0\u9644\u8fd1\u3002\u8fd9\u4e24\u4e2a\u57fa\u56e0\u90fd\u53c2\u4e0e\u708e\u75c7\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u53ef\u80fd\u652f\u6301\u4e86\u708e\u75c7\u5728PD\u4e2d\u53d1\u6325\u4f5c\u7528\u3002<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span> 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data-contrast=\"auto\">\u201c\u6211\u4eec\u6709\u6765\u81ea\u4e16\u754c\u5404\u5730\u7684\u4eba\u4eec\u4e00\u8d77\u5de5\u4f5c\uff0c\u76f8\u4e92\u5b66\u4e60\uff0c\u201dNacho\u8bf4\u3002\u201c\u5728\u6211\u770b\u6765\uff0c\u8fd9\u6b21\u5408\u4f5c\u662f\u5173\u4e8e\u8fd9\u9879\u7814\u7a76\u548c\u672a\u6765\u53ef\u80fd\u6027\u6700\u4ee4\u4eba\u5174\u594b\u7684\u4e8b\u60c5\u201d\u3002<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span> <\/span><\/p>\n<p><span data-contrast=\"auto\"><span data-contrast=\"auto\">\u6211\u4eec\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u5b9e\u9a8c\u5ba4\u7814\u7a76\u6765\u8bc1\u5b9e\u8fd9\u9879\u7814\u7a76\u4e2d\u53d1\u73b0\u7684\u7279\u5b9a\u57fa\u56e0\u4f4d\u70b9\u5982\u4f55\u5f71\u54cdPD\u7684\u53d1\u75c5\u9014\u5f84\u548c\u75be\u75c5\u8868\u73b0\u3002\u4e0d\u8fc7\uff0c\u8fd9\u9879\u5de5\u4f5c\u4e3a\u4eca\u540e\u7684\u7814\u7a76\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u57fa\u7840<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559740&quot;:276}\">\u00a0<\/span> <\/span><\/p>\n<p><span data-contrast=\"auto\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-50004523\" src=\"https:\/\/gp2.org\/wp-content\/uploads\/2024\/01\/41588_2023_1584_Fig1_.jpeg\" alt=\"\" width=\"685\" height=\"772\" srcset=\"https:\/\/gp2.org\/wp-content\/uploads\/2024\/01\/41588_2023_1584_Fig1_.jpeg 685w, https:\/\/gp2.org\/wp-content\/uploads\/2024\/01\/41588_2023_1584_Fig1_-266x300.jpeg 266w, https:\/\/gp2.org\/wp-content\/uploads\/2024\/01\/41588_2023_1584_Fig1_-256x289.jpeg 256w, https:\/\/gp2.org\/wp-content\/uploads\/2024\/01\/41588_2023_1584_Fig1_-512x577.jpeg 512w, https:\/\/gp2.org\/wp-content\/uploads\/2024\/01\/41588_2023_1584_Fig1_-639x720.jpeg 639w\" sizes=\"auto, (max-width: 685px) 100vw, 685px\" \/><\/span><\/p>\n<p><span data-contrast=\"auto\"> <i><span data-contrast=\"auto\">\u8fd9\u9879\u5de5\u4f5c\u5f97\u5230\u4e86\u4ee5\u4e0b\u673a\u6784\u7684\u652f\u6301\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u3001\u7f8e\u56fd\u56fd\u7acb\u8001\u9f84\u5316\u7814\u7a76\u6240\uff08NIA\uff09\u3001\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u3001\u7f8e\u56fd\u536b\u751f\u4e0e\u516c\u4f17\u670d\u52a1\u90e8\u3001\u7f8e\u56fd\u56fd\u7acb\u795e\u7ecf\u75be\u75c5\u4e0e\u4e2d\u98ce\u7814\u7a76\u6240\u3001\u5e15\u91d1\u68ee\u57fa\u91d1\u4f1a\u3001\u8fc8\u514b\u5c14-J-\u798f\u514b\u65af\u57fa\u91d1\u4f1a\u3001\u5168\u7403\u5e15\u91d1\u68ee\u9057\u4f20\u9879\u76ee\u79d1\u5b66\u8054\u76df\uff08ASAP-GP2\uff09\u3001\u7f8e\u56fd\u5e15\u91d1\u68ee\u75c5\u534f\u4f1a\u3001\u65b0\u52a0\u5761\u56fd\u5bb6\u533b\u5b66\u7814\u7a76\u7406\u4e8b\u4f1a\u548c\u65b0\u52a0\u5761\u6559\u80b2\u90e8\u5b66\u672f\u7814\u7a76\u57fa\u91d1\u4e3a\u672c\u7814\u7a76\u63d0\u4f9b\u4e86\u652f\u6301\u3002 <\/span><\/i><\/span><\/p>\n<p><i><span 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data-contrast=\"auto\">)\u3002<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5e15\u91d1\u68ee\u75c5(PD)\u4e00\u76f4\u662f\u9057\u4f20\u5b66\u7814\u7a76\u7684\u70ed\u70b9\u3002\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u786e\u5b9a\u4e8690\u591a\u79cd\u53ef\u80fd\u5f71\u54cd\u4e2a\u4eba\u60a3\u5e15\u91d1\u68ee\u75c5\u98ce\u9669\u7684\u57fa\u56e0\u53d8\u5f02\uff0c\u63ed\u793a\u4e86 [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":50024646,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50012100","post","type-post","status-publish","format-standard","hentry","post-type-743","post-type-724","topic-research-collaboration-3","topic-research-operations-2","topic---6","topic---3"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50012100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/comments?post=50012100"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50012100\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media\/50024646"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media?parent=50012100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}