{"id":50012045,"date":"2023-08-25T20:35:41","date_gmt":"2023-08-26T00:35:41","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/collaborative-science%ef%bc%88%e7%a7%91%e7%a0%94%e5%8d%8f%e4%bd%9c%ef%bc%89%e6%8f%ad%e5%bc%80-gba1%e5%9f%ba%e5%9b%a0%e7%9a%84%e7%a5%9e%e7%a7%98%e9%9d%a2%e7%ba%b1\/"},"modified":"2024-11-26T14:06:48","modified_gmt":"2024-11-26T19:06:48","slug":"collaborative-science%ef%bc%88%e7%a7%91%e7%a0%94%e5%8d%8f%e4%bd%9c%ef%bc%89%e6%8f%ad%e5%bc%80-gba1%e5%9f%ba%e5%9b%a0%e7%9a%84%e7%a5%9e%e7%a7%98%e9%9d%a2%e7%ba%b1","status":"publish","type":"post","link":"https:\/\/gp2.org\/zh-hans\/collaborative-science%ef%bc%88%e7%a7%91%e7%a0%94%e5%8d%8f%e4%bd%9c%ef%bc%89%e6%8f%ad%e5%bc%80-gba1%e5%9f%ba%e5%9b%a0%e7%9a%84%e7%a5%9e%e7%a7%98%e9%9d%a2%e7%ba%b1\/","title":{"rendered":"Collaborative Science\uff08\u79d1\u7814\u534f\u4f5c\uff09\u63ed\u5f00 GBA1\u57fa\u56e0\u7684\u795e\u79d8\u9762\u7eb1"},"content":{"rendered":"<h2>\u4eba\u7c7b\u9996\u6b21\u5728\u975e\u6d32\u88d4\u4eba\u7fa4\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u7684\u5e15\u91d1\u68ee\u75c5\u98ce\u9669\u56e0\u5b50\uff0c\u8fd9\u8868\u660e\u5438\u7eb3\u4ee3\u8868\u6027\u4e0d\u8db3\u7684\u4eba\u7fa4\u7684\u91cd\u8981\u6027\u3002<\/h2>\n<p>\u968f\u7740\u7b2c\u4e00\u4e2a\u9488\u5bf9\u975e\u6d32\u88d4\u4eba\u7fa4\u7684\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u9057\u4f20\u98ce\u9669\u56e0\u5b50\u7684\u53d1\u73b0\uff0c\u5e15\u91d1\u68ee\u75c5\u9886\u57df\u7684\u53d1\u5c55\u524d\u666f\u4ee4\u4eba\u632f\u594b\u3002\u6b64\u65f6\u6b64\u523b\uff0c\u6211\u4eec\u770b\u5230\u4e86\u5e0c\u671b\uff0c\u8fd9\u4e2a\u9886\u57df\u6b63\u9010\u6b65\u671d\u7740\u8fd9\u4e2a\u65b9\u5411\u53d1\u5c55\uff1a\u4eba\u4eec\u5c06\u66f4\u5168\u9762\u5730\u4e86\u89e3\u75be\u75c5\u98ce\u9669\u548c\u8fdb\u5c55\u7684\u9057\u4f20\u56e0\u7d20\u2014\u2014\u8fd9\u4e9b\u57fa\u56e0\u7814\u7a76\u6210\u679c\u5c06\u5f88\u5feb\u60e0\u53ca\u90a3\u4e9b\u957f\u671f\u4ee5\u6765\u5728\u7814\u7a76\u4e2d\u4ee3\u8868\u6027\u4e0d\u8db3\u3001\u65e0\u6cd5\u83b7\u5f97\u5145\u5206\u533b\u7597\u670d\u52a1\u7684\u4eba\u3002<a href=\"http:\/\/gp2.org\" target=\"_blank\" rel=\"noopener\">\u5168\u7403\u5e15\u91d1\u68ee\u57fa\u56e0\u8ba1\u5212\uff08GP2)<\/a>\u6b63\u901a\u8fc7\u5176\u5305\u5bb9\u6027\u7684\u5408\u4f5c\u7814\u7a76\u6a21\u5f0f\uff0c\u4e3a\u66f4\u591a\u8fd9\u6837\u6709\u5f71\u54cd\u529b\u7684\u53d1\u73b0\u94fa\u5e73\u9053\u8def\u3002<\/p>\n<p>\u7b80\u800c\u8a00\u4e4b\uff0c\u6211\u4eec\u5df2\u7ecf\u53d1\u73b0 GBA1 \u57fa\u56e0\u4e2d\u7684\u53d8\u4f53\u4f1a\u589e\u52a0\u7f79\u60a3\u5e15\u91d1\u68ee\u75c5\u7684\u98ce\u9669\u3002\u8fd9\u4e9b\u53d8\u4f53\u5728\u5177\u6709\u5317\u6b27\u548c\u963f\u4ec0\u80af\u7eb3\u5179\u72b9\u592a\u8840\u7edf\u7684\u4eba\u4e2d\u51fa\u73b0\u7684\u9891\u7387\u6700\u9ad8\u3002\u4eca\u5929\uff0cGP2 \u62a5\u544a\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u7684 GBA1 \u53d8\u5f02\u4f53\uff0c\u8fd9\u662f\u975e\u6d32\u4eba\u548c\u975e\u6d32\u6df7\u8840\u513f\u7279\u6709\u7684\u3002\u8fd9\u79cd\u53d8\u5f02\u4f7f\u60a3\u5e15\u91d1\u68ee\u75c5\u7684\u98ce\u9669\u5927\u5927\u589e\u52a0\uff0c\u5982\u679c\u53ea\u6709\u4e00\u4e2a\u62f7\u8d1d\uff0c\u98ce\u9669\u4f1a\u589e\u52a0 1.5 \u500d\uff1b\u5982\u679c\u6709\u4e24\u4e2a\u7a81\u53d8\u62f7\u8d1d\u90fd\u88ab\u9057\u4f20\uff0c\u98ce\u9669\u4f1a\u589e\u52a0 3-4 \u500d\u3002\u867d\u7136\u8fd9\u79cd\u53d8\u4f53\u5728\u5c3c\u65e5\u5229\u4e9a\u7684\u4e00\u4e2a\u5e15\u91d1\u68ee\u75c5\u961f\u5217\u4e2d\u5f88\u5e38\u89c1\uff0c\u4f46\u5728\u4e16\u754c\u5176\u4ed6\u4eba\u7fa4\u4e2d\u5374\u975e\u5e38\u7f55\u89c1\uff0c\u56e0\u6b64\u76f4\u5230\u73b0\u5728\u624d\u88ab\u53d1\u73b0\u3002<\/p>\n<h4><i>GP2\u662f\u4ec0\u4e48\uff1f<\/i><\/h4>\n<p>GP2 \u4e8e 2019 \u5e74\u542f\u52a8\uff0c\u662f\u5e15\u91d1\u68ee\u79d1\u5b66\u8054\u76df\uff08ASAP\uff09 \u7684\u9996\u4e2a\u8d44\u6e90\u8ba1\u5212\u3002\u5176\u76ee\u7684\u662f\u901a\u8fc7\u5bf9\u6765\u81ea\u4e16\u754c\u5404\u5730\u7684 150,000 \u591a\u540d\u5fd7\u613f\u8005\u8fdb\u884c\u57fa\u56e0\u5206\u578b\uff0c\u6781\u5927\u5730\u6269\u5c55\u6211\u4eec\u5bf9\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u57fa\u7840\u7684\u4e86\u89e3\uff0c\u5e76\u4f7f\u8fd9\u4e9b\u77e5\u8bc6\u5728\u5168\u7403\u5177\u6709\u666e\u9002\u6027\uff0c\u8be5\u6570\u636e\u96c6\u4e00\u65e6\u5b8c\u6210\uff0c\u5c06\u6210\u4e3a\u89c4\u6a21\u6700\u5927\u3001\u8840\u7edf\u6700\u591a\u6837\u5316\u7684\u5e15\u91d1\u68ee\u75c5\u6570\u636e\u96c6\u3002\u7531\u4e8e\u6211\u4eec\u76ee\u524d\u5bf9\u5e15\u91d1\u68ee\u75c5\u7684\u4e86\u89e3\u2014\u2014\u4e0e\u5176\u4ed6\u75be\u75c5\u9886\u57df\u4e00\u6837\u2014\u2014\u5e76\u6ca1\u6709\u53cd\u6620\u51fa\u8be5\u75be\u75c5\u60a3\u8005\u7684\u591a\u6837\u6027\uff0c\u56e0\u6b64\u6211\u4eec\u5bf9\u8be5\u75be\u75c5\u7684\u4e86\u89e3\u5e76\u4e0d\u5168\u9762\u3002\u8fd9\u5bf9\u836f\u7269\u5f00\u53d1\u3001\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u548c\u53c2\u4e0e\uff0c\u4ee5\u53ca\u4e0b\u6e38\u7684\u62a4\u7406\u5dee\u5f02\u90fd\u6709\u5de8\u5927\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u6211\u4e0d\u4ec5\u632f\u594b\u4e8e\u8fd9\u9879\u8ba1\u5212\u7684\u5de5\u4f5c\u8303\u56f4\u548c\u89c4\u6a21\uff0c\u8fd8\u6709 GP2 \u4e3a\u5b9e\u73b0\u8fd9\u9879\u8ba1\u5212\u6240\u91c7\u53d6\u7684\u6218\u7565\u3002\u5728Andrew Singleton\u535a\u58eb\u548cCornelis Blauwendraat\u535a\u58eb\u7684\u9886\u5bfc\u4e0b\uff0cGP2\u5236\u5b9a\u4e86\u4e00\u4e2a\u53ef\u884c\u7684\u84dd\u56fe\uff0c\u8ba9GP2 \u52a9\u529b\u533b\u5b66\u53d1\u73b0\u548c\u80fd\u529b\u5efa\u8bbe\uff0c\u4e3a\u5168\u7403\u7814\u7a76\u754c\u63d0\u4f9b\u6280\u80fd\u7ec4\u5408\u3001\u5de5\u5177\u548c\u57fa\u7840\u8bbe\u65bd\uff0c\u4ee5\u5feb\u901f\u9ad8\u6548\u5730\u89e3\u51b3\u65b0\u7684\u7814\u7a76\u9700\u6c42\u548c\u95ee\u9898\u3002GP2\u7684\u5408\u4f5c\u8005\u904d\u5e03\u516d\u5927\u6d32\u7684\u81f3\u5c1155 \u4e2a\u7684\u5730\u70b9\uff0c\u6bcf\u4e2a\u5730\u70b9\u90fd\u6709\u6837\u672c\u3002\u8003\u8651\u5230\u8fc4\u4eca\u4e3a\u6b62\u5927\u591a\u6570\u5927\u89c4\u6a21\u57fa\u56e0\u7814\u7a76\u5de5\u4f5c\u90fd\u662f\u5728\u6b27\u6d32\u8840\u7edf\u7684\u4e2a\u4f53\u4e2d\u8fdb\u884c\u7684\uff08\u4f30\u8ba1\u6bd4\u4f8b\u5728 <a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01672-4.epdf?sharing_token=4S_y467MybhxcXJ975aDDtRgN0jAjWel9jnR3ZoTv0MazbjTFAdIZAhM7O2cKQSpjl00XrWbFdEWbPkh3dLrfbCnd1qUYGlUVrk7KVMvgc0kT58VefY3A-NCtYyJotjPc4wQq3ek3fwM6kZkApDF8ntjmDAXrqyYJV9Iv3xSVOZAlUDELu8hBlobQH88loabUaCWaKQLlhNDiaC9b32zAg%3D%3D&amp;tracking_referrer=www.bbc.com\" target=\"_blank\" rel=\"noopener\">86%<\/a> &#8211; <a href=\"https:\/\/www.nature.com\/articles\/538161a\" target=\"_blank\" rel=\"noopener\">96%<\/a> \u4e4b\u95f4\uff09\uff0c\u8fd9\u65e2\u662f\u4e00\u9879\u8270\u5de8\u7684\u4efb\u52a1\uff0c\u4e5f\u662f\u671d\u7740\u6b63\u786e\u65b9\u5411\u8fc8\u51fa\u7684\u91cd\u8981\u4e00\u6b65\u3002<\/p>\n<p>\u5b9e\u8df5\u4e2d\u7684\u4e3b\u8981\u5de5\u4f5c\u6d41\u7a0b\u662f\u4ec0\u4e48\uff1f\u4efb\u4f55\u5408\u683c\u7684\u7814\u7a76\u4eba\u5458\u90fd\u53ef\u4ee5\u6210\u4e3a GP2 \u7684\u4e00\u5458\uff0c\u53ea\u8981\u4ed6\u4eec\u613f\u610f\u4e0eGP2\u5171\u4eab\u4e00\u4e2a\u961f\u5217\u6216\u63d0\u4f9b\u4e13\u4e1a\u77e5\u8bc6\u3002\u7136\u540e\uff0cGP2 \u4f5c\u4e3a\u4e2d\u5fc3\u67a2\u7ebd\uff0c\u751f\u6210\u57fa\u56e0\u6570\u636e\u5e76\u534f\u8c03\u76f8\u5e94\u7684\u4e34\u5e8a\u6570\u636e\u3002\u57fa\u56e0\u6570\u636e\u4f1a\u8fd4\u56de\u7ed9\u4f5c\u51fa\u8d21\u732e\u7684\u7814\u7a76\u4eba\u5458\uff0c\u5e76\u88ab\u63a8\u9001\u5230 GP2 \u4e2d\u592e\u8ba1\u7b97\u5de5\u4f5c\u533a\u3002\u4efb\u4f55 GP2 \u6210\u5458\u90fd\u53ef\u4ee5\u63d0\u51fa\u5206\u6790\u5efa\u8bae\uff0c\u5e76\u8bf7\u6c42\u6280\u672f\u6216\u8ba1\u7b97\u652f\u6301\uff0c\u4ee5\u4fbf\u5206\u6790\u6570\u636e\u3002\u7136\u540e\uff0c\u8fd9\u4e9b\u6210\u679c\u548c\u8f85\u52a9\u6570\u636e\u5c06\u4e0e\u7814\u7a76\u754c\u7684\u5176\u4ed6\u6210\u5458\u5171\u4eab\u3002<\/p>\n<h4><b><i>\u56de\u987e\u8fc7\u53bb\uff1a\u6211\u4eec\u5982\u4f55\u8d70\u5230\u4eca\u5929<\/i><\/b><\/h4>\n<p>GP2 \u9879\u76ee\u7684\u524d\u4e24\u5e74\u4e3b\u8981\u96c6\u4e2d\u5728\u8fd0\u8425\u548c\u80fd\u529b\u5efa\u8bbe\u65b9\u9762\u2014\u2014\u8fc4\u4eca\u4e3a\u6b62\u6c47\u96c6\u4e86\u6765\u81ea 59 \u4e2a\u56fd\u5bb6\u7684 147 \u4e2a\u73b0\u6709\u961f\u5217\uff0c\u786e\u4fdd\u4e86\u77e5\u60c5\u540c\u610f\u548c\u6570\u636e\u5171\u4eab\u6743\u9650\u5408\u89c4\uff0c\u5efa\u7acb\u4e86\u5168\u7403\u5404\u4e2a\u793e\u533a\u4e4b\u95f4\u7684\u4fe1\u4efb\uff0c\u5e76\u5efa\u7acb\u4e86\u4e2d\u592e\u5de5\u4f5c\u6d41\u7a0b\u7ba1\u9053\u3002\u91cd\u8981\u7684\u662f\uff0c\u5927\u529b\u53d1\u5c55\u5168\u7403\u591a\u6837\u6027\u662f\u8fd9\u4e00\u4e8b\u4e1a\u7684\u652f\u67f1\u4e4b\u4e00\uff0c\u4ece\u5728\u63d0\u4f9bGP2 \u9886\u5bfc\u5c42\u7684\u591a\u6837\u6027\uff0c\u5230\u4e3a\u4e2d\u4f4e\u6536\u5165\uff08LMIC\uff09\u56fd\u5bb6\u4ee5\u53ca\u7f8e\u56fd\u4ee3\u8868\u6027\u4e0d\u8db3\u7684\u4eba\u7fa4\u7684\u6837\u672c\u6536\u96c6\u5de5\u4f5c\u63d0\u4f9b\u8d44\u91d1\u3002<\/p>\n<p>\u53bb\u5e74\uff0cGP2 \u5c06\u91cd\u70b9\u4ece\u8fd0\u8425\u548c\u57fa\u7840\u8bbe\u65bd\u8f6c\u5411\u6570\u636e\u751f\u6210\u3002\u5176\u4e2d\u4e00\u9879\u521d\u6b65\u5206\u6790\u662f\u9488\u5bf9\u5c3c\u65e5\u5229\u4e9a\u961f\u5217\u8fdb\u884c\u7684\u3002\u7531\u4e8e\u6837\u672c\u91cf\u8f83\u5c0f\uff08\u8fd1 1000 \u4e2a\u75c5\u4f8b\uff09\uff0c\u5bf9\u7ed3\u679c\u7684\u9884\u671f\u8f83\u4f4e\uff0c\u56e0\u6b64\u8be5\u5206\u6790\u5f53\u65f6\u88ab\u89c6\u4e3a\u751f\u7269\u4fe1\u606f\u5b66\u57f9\u8bad\u673a\u4f1a\u3002\u4e3a\u4e86\u53d1\u73b0\u65b0\u7684\u9057\u4f20\u98ce\u9669\u56e0\u5b50\uff0c\u5927\u89c4\u6a21\u9057\u4f20\u7814\u7a76\u4e2d\u7684\u53c2\u4e0e\u8005\u75c5\u4f8b\u6570\u901a\u5e38\u5728\u6570\u4e07\u5230\u6570\u5341\u4e07\u4e4b\u95f4\u3002\u5f53\u7ed3\u679c\u8868\u660e\u53ef\u80fd\u53d1\u73b0\u4e86\u65b0\u7684\u98ce\u9669\u53d8\u4f53\u65f6\uff0c\u5c31\u4f1a\u91cd\u65b0\u8fdb\u884c\u5206\u6790\uff0c\u4ee5\u589e\u52a0\u53ef\u4fe1\u5ea6\u3002\u8fd9\u4e00\u53d1\u73b0\u968f\u540e\u5728\u4e00\u9879\u72ec\u7acb\u7684\u7814\u7a76\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\uff0c\u7814\u7a76\u5bf9\u8c61\u662f\u53c2\u4e0e <a href=\"https:\/\/www.centerwatch.com\/us\/en\/clinicaltrial\/260407\/black-and-african-american-connections-to-parkinsons-disease-blaac-pd-study\/\" target=\"_blank\" rel=\"noopener\">BLAAC-PD<\/a>\u7814\u7a76\u7684\u4e2a\u4eba\uff0c\u8be5\u7814\u7a76\u662f\u7531 GP2 \u652f\u6301\u5728\u7f8e\u56fd\u4e3a\u975e\u6d32\u548c\u975e\u6d32\u6df7\u8840\u8840\u7edf\u7684\u4eba\u5f00\u5c55\u7684\u4e00\u9879\u6536\u96c6\u5de5\u4f5c\uff1b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u79cd\u98ce\u9669\u53d8\u4f53\u5728\u897f\u975e\u4ee5\u5916\u7684\u975e\u6d32\u4eba\u7fa4\u4e2d\u666e\u904d\u5b58\u5728\u3002<\/p>\n<h4>\u5f71\u54cd\u3001\u672a\u51b3\u95ee\u9898\u548c\u65b0\u89c6\u91ce<\/h4>\n<p>\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\uff0c\u5728\u7528\u57fa\u7840\u77e5\u8bc6\u6539\u5584\u4eba\u7c7b\u5065\u5eb7\u7684\u8fc7\u7a0b\u4e2d\uff0c\u575a\u6301\u5305\u5bb9\u6027\u79d1\u5b66\u7684\u505a\u6cd5\uff0c\u53ef\u80fd\u4f1a\u5e26\u6765\u98a0\u8986\u6027\u7684\u53d1\u73b0\u3002\u867d\u7136\u8fd9\u4e00\u53d1\u73b0\u51fa\u4e4e\u610f\u6599\uff0c\u4f46 GP2 \u4e3a\u8fd9\u4e00\u53d1\u73b0\u7684\u8bde\u751f\u521b\u9020\u4e86\u4e00\u4e2a\u751f\u6001\u7cfb\u7edf\u548c\u57fa\u7840\u8bbe\u65bd\u3002\u5728\u4efb\u4f55\u7c7b\u578b\u7684\u5927\u89c4\u6a21\u9057\u4f20\u7814\u7a76\u4e2d\uff0c\u7ea6\u6709 2% \u7684\u4e2a\u4f53\u662f\u975e\u6d32\u540e\u88d4 [ <a href=\"https:\/\/www.cell.com\/fulltext\/S0092-8674(19)30231-4\" target=\"_blank\" rel=\"noopener\">Sirugo et al., Cell 2019<\/a> ]\uff0c\u800c\u975e\u6d32\u4eba\u53e3\u7ea6\u5360\u4e16\u754c\u4eba\u53e3\u7684 18%\u3002\u6b64\u5916\uff0c\u4eba\u4eec\u901a\u5e38\u8ba4\u4e3a\u810a\u9ad3\u7070\u8d28\u708e\u5728\u975e\u6d32\u4eba\u548c\u975e\u88d4\u7f8e\u56fd\u4eba\u4e2d\u53d1\u75c5\u7387\u8f83\u4f4e(Bailey et al, 2020, Okubadejo 2007)\uff0c\u4f46\u8fd9\u4e00\u8bf4\u6cd5\u5b58\u5728\u4e89\u8bae\uff0c\u56e0\u4e3a\u7ecf\u5e38\u6709\u7ed3\u8bba\u76f8\u4e92\u77db\u76fe\u7684\u62a5\u544a\u51fa\u73b0\uff0c\u751a\u81f3\u6db5\u76d6\u8fd9\u4e9b\u4eba\u7fa4\u7684\u7814\u7a76\u4e5f\u5f88\u5c11\u3002<\/p>\n<p>\u4f5c\u4e3a\u4e00\u540d\u6709\u7740\u5c3c\u65e5\u5229\u4e9a\u8840\u7edf\u7684\u9ed1\u4eba\u5973\u6027\uff0c\u8fd9\u4e00\u53d1\u73b0\u5bf9\u6211\u7684\u89e6\u52a8\u5f88\u5927\u3002\u5728\u57fa\u56e0\u7814\u7a76\u4e2d\uff0c\u6211\u5f88\u5c11\u770b\u5230\u548c\u6211\u540c\u6837\u8840\u7edf\u7684\u4eba\uff0c\u56e0\u6b64\uff0c\u80fd\u591f\u5728\u4e00\u7ebf\u53c2\u4e0e\u4e00\u9879\u5bf9\u6211\u7684\u793e\u533a\u548c\u6240\u6709\u5177\u6709\u76f8\u4f3c\u8840\u7edf\u7684\u4eba\u90fd\u6709\u5b9e\u9645\u610f\u4e49\u7684\u53d1\u73b0\uff0c\u6211\u611f\u5230\u7279\u522b\u6b23\u6170\u3002\u968f\u7740\u57fa\u4e8e\u57fa\u56e0\u7684\u7cbe\u51c6\u6cbb\u7597\u8bd5\u9a8c\u8d8a\u6765\u8d8a\u666e\u904d\uff0c\u5f53\u52a1\u4e4b\u6025\u662f\u7f29\u5c0f\u5927\u578b\u9057\u4f20\u5b66\u7814\u7a76\u7684\u591a\u6837\u6027\u5dee\u8ddd\uff0c\u56e0\u4e3a\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u7684\u7ed3\u679c\u53ef\u80fd\u65e0\u6cd5\u5728\u4e0d\u540c\u79cd\u65cf\u7fa4\u4f53\u4e4b\u95f4\u590d\u5236\uff0cGP2 \u7684\u8fd9\u4e00\u53d1\u73b0\u4ee5\u53ca\u4e0d\u540c\u75be\u75c5\u9886\u57df\u7684\u5176\u4ed6\u53d1\u73b0\u90fd\u8bc1\u660e\u4e86\u8fd9\u4e00\u70b9\uff08\u4f8b\u5982\uff0cCYP2D6 \u53d8\u4f53\u52a0\u5267\u4e86\u4e0d\u540c\u4eba\u7fa4\u5728\u6297\u764c\u836f\u7269[\u4ed6\u83ab\u6614\u82ac]\u4ee3\u8c22\u65b9\u9762\u7684\u5dee\u5f02[ <a href=\"https:\/\/www.nature.com\/articles\/538161a\" target=\"_blank\" rel=\"noopener\">Popejoy &amp; Fullerton.Nature 2016<\/a> ]\uff0c\u80c6\u56fa\u9187\u9776\u5411\u6cbb\u7597[PCSK9 \u6291\u5236\u5242]\u7684\u8fdb\u6b65\u662f\u7531\u975e\u88d4\u7f8e\u56fd\u4eba\u53c2\u4e0e\u7814\u7a76\u63a8\u52a8\u7684 [ <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15654334\/\" target=\"_blank\" rel=\"noopener\">Cohen et al., Nat Gen 2005<\/a> ])\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3a\u975e\u6d32\u8840\u7edf\u7684\u4eba\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u673a\u4f1a\u3002<\/p>\n<p>\u5173\u4e8e GBA1\u57fa\u56e0\u5982\u4f55\u5bfc\u81f4\u5e15\u91d1\u68ee\u75c5\uff0c\u4ecd\u7136\u5b58\u5728\u8bb8\u591a\u7591\u95ee\u3002\u8d5b\u8bfa\u83f2\uff08Sanofi\uff09\u516c\u53f8\u9488\u5bf9 GBA1\u57fa\u56e0 \u8fdb\u884c\u7684\u9996\u6279\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u4e00\uff08Venglustat\uff09\u7684\u7ed3\u679c\u662f\uff0c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37479372\/\" target=\"_blank\" rel=\"noopener\">\u6cbb\u7597\u7ec4\u7684\u8868\u73b0\u6bd4\u5b89\u6170\u5242\u7ec4\u5dee<\/a>\uff0c\u8fd9\u8868\u660e\u4eba\u4eec\u5bf9\u5b9e\u9645\u75be\u75c5\u673a\u5236\u7684\u8ba4\u8bc6\u4e0d\u8db3\u3002\u901a\u8fc7\u7814\u7a76\u66f4\u591a\u4e0e\u75be\u75c5\u76f8\u5173\u7684 GBA1 \u53d8\u4f53\uff0c\u6211\u4eec\u53ef\u4ee5\u66f4\u597d\u5730\u4e86\u89e3 GBA1 \u53d8\u4f53\u662f\u5982\u4f55\u5bfc\u81f4\u75be\u75c5\u7684\uff0c\u5e76\u52a0\u5f3a\u9488\u5bf9\u8fd9\u4e00\u75be\u75c5\u76f8\u5173\u9014\u5f84\u7684\u6cbb\u7597\u3002\u91cd\u8981\u7684\u662f\uff0c\u901a\u8fc7\u5728\u5168\u7403\u4e0d\u540c\u4eba\u7fa4\u4e2d\u7814\u7a76\u8fd9\u4e9b\u53d8\u5f02\uff0c\u6211\u4eec\u53ef\u4ee5\u6269\u5927\u53ef\u80fd\u4ece GBA1 \u9776\u5411\u7597\u6cd5\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\u7fa4\u4f53\u3002<\/p>\n<p>\u968f\u7740 GP2 \u7ee7\u7eed\u7ed9\u53d1\u73b0\u5f15\u64ce\u52a0\u901f\uff0c\u6211\u4eec\u671f\u671b\u5728\u4e16\u754c\u5404\u5730\u7684\u4eba\u7fa4\u4e2d\u6709\u66f4\u591a\u7684\u53d1\u73b0\uff0c\u4ece\u800c\u6539\u53d8\u6211\u4eec\u7684\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6cd5\uff0c\u5e76\u4e30\u5bcc\u6211\u4eec\u5bf9\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u7ed3\u6784\u7684\u7406\u89e3\u3002\u53cd\u601d GP2 \u521b\u5efa\u7684\u751f\u6001\u7cfb\u7edf\u3001\u6211\u4eec\u53d1\u5c55\u51fa\u7684\u80fd\u529b\u4ee5\u53ca\u6211\u4eec\u6253\u9020\u7684\u7684\u7814\u7a76\u5458\u8054\u76df\uff0c\u5305\u5bb9\u6027\u5408\u4f5c\u7684\u6548\u679c\u662f\u663e\u800c\u6613\u89c1\u7684\u3002\u7f72\u540d\u753178\u4f4d\u4f5c\u8005\u7ec4\u6210\uff0c\u4ee3\u8868\u4e86\u5c3c\u65e5\u5229\u4e9a24\u4e2a\u4e0d\u540c\u7684\u673a\u6784\uff0c\u7a81\u51fa\u4e86GP2\u56e2\u961f\u3001\u56fd\u9645\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u7ec4\u5b66\u8054\u76df\uff08IPDGC\uff09\u5c3c\u65e5\u5229\u4e9a\u5206\u4f1a\u3001\u8fc8\u514b\u5c14-J-\u798f\u514b\u65af\u57fa\u91d1\u4f1a\u548c23andMe\u4e4b\u95f4\u7684\u5408\u4f5c\u6210\u679c\u3002<\/p>\n<p>\u8bf7\u5bc6\u5207\u5173\u6ce8\u8be5\u8ba1\u5212\uff0c\u6211\u4eec\u5c06\u4e3a\u60a8\u5e26\u6765\u66f4\u591a\u7cbe\u5f69\u6545\u4e8b\uff01<\/p>\n<p><span class=\"ui-provider cij cik c d e f g h i j k l m n o p q r s t cil cim w x y z ab ac ae af ag ah ai aj ak\" dir=\"ltr\">\u514d\u8d23\u58f0\u660e\uff1a\u8fd9\u4e00\u53d1\u73b0\u662f\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u5b66\u7814\u7a76\u7684\u4e00\u4e2a\u91cd\u8981\u91cc\u7a0b\u7891\uff1b\u4e0d\u8fc7\uff0c\u8fd9\u4e00\u53d1\u73b0\u76ee\u524d\u8fd8\u6ca1\u6709\u5bf9\u6cbb\u7597\u4ea7\u751f\u5f71\u54cd\u3002\u00a0 \u94fe\u63a5\u9605\u8bfb<a href=\"https:\/\/protect-eu.mimecast.com\/s\/Rcn6CX7EDTMZQOokc6_VRg?domain=michaeljfox.org\" target=\"_blank\" rel=\"noopener\">\u5e38\u89c1\u95ee\u9898\u4e0e\u89e3\u7b54<\/a>\uff0c\u4e86\u89e3\u8fd9\u4e00\u53d1\u73b0\u5bf9\u60a8\u53ef\u80fd\u610f\u5473\u7740\u4ec0\u4e48)\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eba\u7c7b\u9996\u6b21\u5728\u975e\u6d32\u88d4\u4eba\u7fa4\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u65b0\u7684\u5e15\u91d1\u68ee\u75c5\u98ce\u9669\u56e0\u5b50\uff0c\u8fd9\u8868\u660e\u5438\u7eb3\u4ee3\u8868\u6027\u4e0d\u8db3\u7684\u4eba\u7fa4\u7684\u91cd\u8981\u6027\u3002 \u968f\u7740\u7b2c\u4e00\u4e2a\u9488\u5bf9\u975e\u6d32 [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":50024691,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50012045","post","type-post","status-publish","format-standard","hentry","post-type-gp2","post-type-751","post-type-743","post-type-726","topic-gp2-values-2","topic-research-collaboration-3"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50012045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/comments?post=50012045"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50012045\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media\/50024691"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media?parent=50012045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}