{"id":50012040,"date":"2023-08-16T23:52:11","date_gmt":"2023-08-17T03:52:11","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/%e8%81%9a%e7%84%a6%ef%bc%9a%e4%bb%8b%e7%bb%8d%e6%96%b0%e7%9a%84-gp2-%e9%98%9f%e5%88%97%e6%b5%8f%e8%a7%88%e5%99%a8%e5%ba%94%e7%94%a8\/"},"modified":"2024-10-21T15:38:08","modified_gmt":"2024-10-21T19:38:08","slug":"%e8%81%9a%e7%84%a6%ef%bc%9a%e4%bb%8b%e7%bb%8d%e6%96%b0%e7%9a%84-gp2-%e9%98%9f%e5%88%97%e6%b5%8f%e8%a7%88%e5%99%a8%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"https:\/\/gp2.org\/zh-hans\/%e8%81%9a%e7%84%a6%ef%bc%9a%e4%bb%8b%e7%bb%8d%e6%96%b0%e7%9a%84-gp2-%e9%98%9f%e5%88%97%e6%b5%8f%e8%a7%88%e5%99%a8%e5%ba%94%e7%94%a8\/","title":{"rendered":"\u805a\u7126\uff1a\u4ecb\u7ecd\u65b0\u7684 GP2 \u961f\u5217\u6d4f\u89c8\u5668\u5e94\u7528"},"content":{"rendered":"

GP2 \u7684\u76ee\u7684\u662f\u6781\u5927\u5730\u6269\u5c55\u6211\u4eec\u5bf9\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u57fa\u7840\u7684\u4e86\u89e3\uff0c\u5e76\u4f7f\u8fd9\u4e9b\u77e5\u8bc6\u5728\u5168\u7403\u90fd\u5177\u6709\u666e\u9002\u6027\u3002\u6211\u4eec\u8981\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\uff0c\u5c31\u5fc5\u987b\u5efa\u7acb\u4e00\u4e2a\u5168\u7403\u7814\u7a76\u793e\u533a\uff0c\u4e3a\u89e3\u51b3\u65b0\u7684\u7814\u7a76\u9700\u6c42\u548c\u95ee\u9898\u63d0\u4f9b\u5de5\u5177\u548c\u57fa\u7840\u8bbe\u65bd\u3002\u5728\u6b64\uff0c\u6211\u4eec\u5ba3\u5e03\u63a8\u51fa\u5168\u65b0\u5e94\u7528\u7a0b\u2014\u2014GP2 \u961f\u5217\u6d4f\u89c8\u5668\u3002\u8fd9\u4e00\u9769\u547d\u6027\u7684\u5de5\u5177\u6253\u9020\u51fa\u4e00\u4e2a\u6c89\u6d78\u5f0f\u7684\u4e92\u52a8\u5e73\u53f0\uff0c\u4f7f GP2 \u961f\u5217\u7684\u8d21\u732e\u8005\u548c\u7814\u7a76\u4eba\u5458\u80fd\u591f\u4ee5\u9ad8\u6548\u548c\u7528\u6237\u53cb\u597d\u7684\u65b9\u5f0f\u6df1\u5165\u7814\u7a76\u4e30\u5bcc\u7684\u57fa\u56e0\u7ec4\u6570\u636e\u3002GP2 \u961f\u5217\u6d4f\u89c8\u5668\u7684\u5f00\u53d1\u662f\u4e3a\u4e86\u786e\u4fdd\u90a3\u4e9b\u4f7f\u7528\u6211\u4eec\u7684GP2\u4e2a\u4f53\u9057\u4f20\u5b66\u6570\u636e\u7684\u4eba\u80fd\u591f\u83b7\u5f97\u6d41\u7545\u3001\u5168\u9762\u7684\u6570\u636e\u63a2\u7d22\u4f53\u9a8c\u3002\u8981\u8bbf\u95ee\u8fd9\u4e9b\u6570\u636e\u96c6\u5e76\u4f7f\u7528\u6211\u4eec\u7684\u5de5\u5177\uff0c\u5fc5\u987b\u7b7e\u7f72\u5df2\u83b7\u6279\u51c6\u7684\u7b2c 2 \u7ea7 GP2 \u6570\u636e\u534f\u8bae<\/b>\uff0c\u60a8\u53ef\u4ee5\u4ece\u8fd9\u91cc\u5f00\u59cb\u7533\u8bf7\uff1a https:\/\/amp-pd.org\/register-for-amp-pd \u3002\u60a8\u8fd8\u53ef\u4ee5\u70b9\u51fb<\/span>\u6b64\u5904<\/span><\/a>\u4e86\u89e3\u66f4\u591a\u6709\u5173\u5982\u4f55\u7533\u8bf7\u7684\u4fe1\u606f\u3002\u00a0<\/span><\/p>\n

\u4ee5\u4e0b\u662f\u65b0\u5de5\u5177\u7684\u6982\u8ff0\uff0c\u4e00\u65e6\u60a8\u7b7e\u7f72\u4e86\u6211\u4eec\u7684\u6570\u636e\u4f7f\u7528\u534f\u8bae\uff0c\u5c31\u53ef\u4ee5\u7acb\u5373\u5f00\u59cb\u4f7f\u7528\uff01\u00a0<\/span><\/p>\n

\u60a8\u53ef\u5728\u6b64\u5904\u627e\u5230\u8be5\u6d4f\u89c8\u5668\uff1a https:\/\/gp2-cohort-browser-dot-gp2-release-terra.uc.r.appspot.com\/<\/span><\/p>\n

<\/p>\n

\u767b\u9646\u9875\u9762<\/strong><\/h3>\n

\u767b\u9646\u9875\u9762\u662f\u60a8\u4e86\u89e3\u7f51\u7edc\u5e94\u7528\u7a0b\u5e8f\u6240\u6709\u529f\u80fd\u7684\u7b2c\u4e00\u6b65\u3002\u4e3a\u60a8\u4e4b\u540e\u7684\u63a2\u7d22\u5960\u5b9a\u57fa\u7840\uff0c\u4ece\u8d28\u91cf\u63a7\u5236\u63aa\u65bd\u5230\u7956\u5148\u5206\u7c7b\uff0c\u60a8\u90fd\u53ef\u4ee5\u5728\u767b\u9646\u9875\u9762\u5148\u7779\u4e3a\u5feb\u3002<\/p>\n

\"\"<\/p>\n

\u5168\u9762\u7684\u5143\u6570\u636e\u7ec6\u5206<\/h3>\n

\u6709\u4e86\u8fd9\u4e2a\u5e94\u7528\u7a0b\u5e8f\uff0c\u7814\u7a76\u4eba\u5458\u5c31\u53ef\u4ee5\u8bbf\u95ee\u5b8c\u6574\u7684\u5143\u6570\u636e\u7ec6\u76ee\uff0c\u5305\u62ec\u76f4\u65b9\u56fe\u3002\u60a8\u53ef\u4ee5\u4ece\u4e2d\u8be6\u7ec6\u4e86\u89e3\u961f\u5217\u7684\u4eba\u53e3\u7edf\u8ba1\u5b66\u7279\u5f81\uff0c\u5982\u5e74\u9f84\u3001\u6027\u522b\u548c\u8868\u578b\u3002\u7528\u6237\u53ef\u4ee5\u9009\u62e9\u8981\u68c0\u67e5\u7684\u961f\u5217\u3002<\/p>\n

<\/p>\n

\u8d28\u91cf\u63a7\u5236<\/h3>\n

GP2 \u961f\u5217\u6d4f\u89c8\u5668\u7684\u4e3b\u8981\u7279\u70b9\u4e4b\u4e00\u662f\u4e25\u683c\u6ce8\u91cd\u8d28\u91cf\u63a7\u5236 (QC)\u3002\u901a\u8fc7\u8be5\u5e94\u7528\uff0c\u60a8\u53ef\u4ee5\u8bbf\u95ee\u5e76\u4e86\u89e3\u6211\u4eec\u7684\u8d28\u91cf\u63a7\u5236\u6d41\u7a0b\uff0c\u5305\u62ec\u6837\u672c\u548c\u53d8\u4f53\u7ea7\u8fc7\u6ee4\u3002\u6b64\u5916\uff0c\u60a8\u8fd8\u53ef\u4ee5\u5728\u4e0b\u62c9\u83dc\u5355\u4e2d\u83b7\u5f97\u6700\u65b0\u7684\u8d28\u91cf\u63a7\u5236\u8bf4\u660e\u7684\u8be6\u7ec6\u4fe1\u606f\u3002\u6f0f\u6597\u56fe\u5c06\u8d28\u91cf\u63a7\u5236\u8fc7\u7a0b\u4e00\u6b65\u6b65\u53ef\u89c6\u5316\uff0c\u8ba9\u60a8\u66f4\u597d\u5730\u4e86\u89e3\u6570\u636e\u3002<\/p>\n

<\/p>\n

\u7956\u5148\u5206\u6790<\/h3>\n

GP2 \u961f\u5217\u6d4f\u89c8\u5668\u5e26\u6709\u52a8\u6001\u4e09\u7ef4\u4e3b\u6210\u5206\u5206\u6790 (PCA) \u56fe\uff0c\u53ef\u4ee5\u4ea4\u4e92\u5f0f\u5730\u63a2\u7d22\u9057\u4f20\u7956\u5148\u3002\u8be5\u56fe\u8c31\u5305\u62ec\u53c2\u8003\u9762\u677f\uff0c\u53ef\u8ba9\u60a8\u6309\u9884\u6d4b\u7956\u5148\u63d0\u53d6\u5b50\u96c6\u3002\u5728\u56fe\u4e2d\uff0c\u60a8\u5c06\u770b\u5230\u9884\u6d4b\u7956\u5148\u7684\u8868\u683c\u548c\u997c\u56fe\u5bf9\u6bd4\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u4e86\u89e3\u5206\u5e03\u60c5\u51b5\u3002\u8be5\u5e94\u7528\u7a0b\u5e8f\u8fd8\u63d0\u4f9b\u6df7\u6dc6\u77e9\u9635\u3001\u51c6\u786e\u7387\u548c F1 \u5206\u6570\u7b49\u6a21\u578b\u6027\u80fd\u6307\u6807\u3002 \u4e0b\u4e00\u4e2a\u7248\u672c\uff08\u9884\u8ba1\u4e8e 2023 \u5e74\u521d\u79cb\u53d1\u5e03\uff09\u4e2d\u503c\u5f97\u671f\u5f85\u7684\u66f4\u65b0\u662f\u53c2\u8003\u9762\u677f\u7684\u6df7\u8840\u4eba\u7fa4\u7684\u6269\u5927\uff0c\u91cd\u70b9\u5173\u6ce8\u6df7\u8840\u4eba\u7fa4\uff0c\u5982\u7f8e\u6d32\u5370\u7b2c\u5b89\u4eba\/\u62c9\u4e01\u7f8e\u6d32\u4eba (AMR)\u3001\u4e2d\u4e1c\u4eba (MDE) \u548c\u4e2d\u4e9a\u4eba (CAS)\u3002<\/p>\n

<\/p>\n

SNP \u6307\u6807<\/h3>\n

\u7814\u7a76\u4eba\u5458\u4e00\u65e6\u9009\u62e9\u4e86\u4e00\u4e2a\u7956\u5148\uff0c\u5c31\u6709\u673a\u4f1a\u63a2\u7d22\u6700\u65b0\u53d1\u5e03\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNP\uff09\u6307\u6807\u3002\u7528\u6237\u53ef\u4ee5\u901a\u8fc7 rsID \u6216\u4f4d\u7f6e\uff08\u5728 hg38 \u4e2d\uff09\u641c\u7d22\u805a\u7c7b\u56fe\u3002\u8be5\u529f\u80fd\u8fd8\u63d0\u4f9b\u4e86\u5bf9\u7167\u7ec4\u548c\u75be\u75c5\u7ec4\u7684 GenTrain \u5206\u6570\u548c\u5c0f\u7b49\u4f4d\u57fa\u56e0\u9891\u7387\u5206\u5e03\u3002<\/p>\n

\u5728\u672a\u6765\u7684\u7248\u672c\u4e2d\uff0c\u6211\u4eec\u5c06\u4f7f\u7528\u81ea\u5b9a\u4e49\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\uff0c\u5bf9\u4f4e\u5206\u8fa8\u7387\u53d8\u4f53\u7684\u9884\u6d4b\u96c6\u7fa4\u8fdb\u884c\u6269\u5c55\u3002<\/p>\n

<\/p>\n

\u7f55\u89c1\u53d8\u4f53<\/h3>\n

GP2 \u961f\u5217\u6d4f\u89c8\u5668\u8fd8\u6709\u4e00\u4e2a\u4e13\u95e8\u7528\u4e8e\u63a2\u7d22\u7f55\u89c1\u53d8\u5f02\u7684\u90e8\u5206\u3002\u5b83\u5305\u62ec GP2 \u7684\u5355\u57fa\u56e0\u7f51\u7edc\u63d0\u4f9b\u7684\u4fe1\u606f\uff0c\u5728\u8be5\u7f51\u7edc\u4e2d\uff0c\u53ef\u4ee5\u5bf9\u5df2\u77e5\u7684 PD \u57fa\u56e0\u63d0\u53d6\u5b50\u96c6\uff0c\u4ee5\u4fbf\u8fdb\u884c\u66f4\u6df1\u5165\u7684\u7814\u7a76\u3002\u4fa7\u8fb9\u680f\u7684\u8fc7\u6ee4\u5668\u5141\u8bb8\u7528\u6237\u641c\u7d22\u7279\u5b9a\u57fa\u56e0\uff0c\u800c\u8868\u683c\u5219\u63d0\u4f9b\u4e86\u6240\u6709\u5176\u4ed6\u65b9\u9762\u7684\u7efc\u5408\u6570\u636e\u3002<\/p>\n

<\/p>\n

<\/p>\n

\u7ed3\u8bed<\/strong><\/h3>\n

\u6211\u4eec\u8877\u5fc3\u5e0c\u671b GP2 \u961f\u5217\u6d4f\u89c8\u5668\u80fd\u6210\u4e3a\u60a8\u66f4\u597d\u5730\u4e86\u89e3 GP2 \u6570\u636e\u4ee5\u53ca\u4e3a\u8bba\u6587\u548c\u6d77\u62a5\u5236\u4f5c\u6458\u8981\u56fe\u8868\u7684\u597d\u5de5\u5177\u3002<\/p>\n

GP2 \u7ec4\u7fa4\u6d4f\u89c8\u5668\u5728\u4e0d\u540c\u7248\u672c\u548c\u961f\u5217\u4e4b\u95f4\u4fdd\u6301\u4e00\u81f4\uff0c\u8fd9\u662f\u4e00\u6b21\u5927\u80c6\u7684\u5c1d\u8bd5\uff0c\u63d0\u9ad8\u4e86 GP2 \u8d28\u91cf\u63a7\u5236\u6d41\u7a0b\u6bcf\u4e2a\u6b65\u9aa4\u7684\u900f\u660e\u5ea6\u548c\u53ef\u8bbf\u95ee\u6027\u3002\u6211\u4eec\u8981\u611f\u8c22\u5168\u7403\u6240\u6709\u4e3a GP2 \u5de5\u4f5c\u6350\u732e\u6570\u636e\u7684\u961f\u5217\uff0c\u6ca1\u6709\u4ed6\u4eec\u6211\u4eec\u7684\u5de5\u4f5c\u4e0d\u53ef\u80fd\u53d6\u5f97\u4eca\u65e5\u7684\u6210\u7ee9\u3002<\/p>\n

\u5982\u6709\u4efb\u4f55\u7591\u95ee\u6216\u652f\u6301\uff0c\u8bf7\u8054\u7cfb\u6570\u636e\u5206\u6790\u5de5\u4f5c\u7ec4 dawg@gp2.org \u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Terra\u4e91\u5e73\u53f0\u5141\u8bb8\u60a8\u76f4\u63a5\u5728\u4e91\u7aef\u8fdb\u884c\u5206\u6790\uff0c\u65e0\u9700\u5c06GP2\u6570\u636e\u76f4\u63a5\u4e0b\u8f7d\u5230\u4f60\u7684\u4e2a\u4eba\u7535\u8111\u3002\u8fd9\u7bc7\u535a\u5ba2\u662f\u5173\u4e8e\u5982\u4f55\u5728\u8fd9\u4e2a\u5e73\u53f0\u4e0a\u4f7f\u7528workspace\u548cnotebook\u5206\u6790GP2\u6570\u636e\u7684\u4ecb\u7ecd\u3002<\/p>\n","protected":false},"author":0,"featured_media":50025000,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50012040","post","type-post","status-publish","format-standard","hentry","post-type-2435","post-type-723","topic-complex-disease-genetics-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50012040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/comments?post=50012040"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50012040\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media\/50025000"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media?parent=50012040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}