{"id":50011961,"date":"2022-11-17T21:29:26","date_gmt":"2022-11-18T02:29:26","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/gp2%e7%ac%ac%e4%b8%89%e6%ac%a1%e6%95%b0%e6%8d%ae%e5%8f%91%e5%b8%83%e5%86%85%e5%ae%b9\/"},"modified":"2024-10-21T15:23:12","modified_gmt":"2024-10-21T19:23:12","slug":"gp2%e7%ac%ac%e4%b8%89%e6%ac%a1%e6%95%b0%e6%8d%ae%e5%8f%91%e5%b8%83%e5%86%85%e5%ae%b9","status":"publish","type":"post","link":"https:\/\/gp2.org\/zh-hans\/gp2%e7%ac%ac%e4%b8%89%e6%ac%a1%e6%95%b0%e6%8d%ae%e5%8f%91%e5%b8%83%e5%86%85%e5%ae%b9\/","title":{"rendered":"GP2\u7b2c\u4e09\u6b21\u6570\u636e\u53d1\u5e03\u5185\u5bb9"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">2022\u5e7410\u6708\uff0cGP2\u4e0eAMP<\/span><span style=\"font-weight: 400;\"><sup>\u00ae<\/sup><\/span><span style=\"font-weight: 400;\"> 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400;\">\u4f4d\u4e8e\u571f\u8033\u5176\u7684Koc\u5927\u5b66GP2\u961f\u5217\uff08KOC\uff09<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">LRRK2\u7a81\u53d8\u643a\u5e26\u8005\u7684PD\u961f\u5217\u2014\u2014LRRK2\u961f\u5217\u5c0f\u7ec4\uff08LCC\uff09<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u8fd0\u52a8\u969c\u788d\u7684\u57fa\u56e0\u578b\u548c\u8868\u578b&#8211;\u82f1\u56fd\u8111\u5e93\u4f26\u6566\u56fd\u738b\u5b66\u9662(MDGAP-Kings)\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u65b0\u897f\u5170\u5e15\u91d1\u68ee\u75c5\u8ba1\u5212\uff08NZP3\uff09<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u4e0e\u73af\u5883\u7814\u7a76\uff08PAGE\uff09<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u5e15\u91d1\u68ee\u75c5\u8fdb\u5c55\u6807\u5fd7\u7269\u5021\u8bae\uff08PPMI\uff09<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684PD\u751f\u7269\u6807\u5fd7\u7269\u7814\u7a76\u2014\u2014\u7cfb\u7edf\u6027\u7a81\u89e6\u6838\u86cb\u767d\u62bd\u6837\u7814\u7a76(S4)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 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wp-image-50008086\" src=\"https:\/\/gp2.org\/wp-content\/uploads\/2022\/11\/102049-010_GP2Blogs_DataChart_3_v1r168-1-1.jpg\" alt=\"\" width=\"850\" height=\"652\" srcset=\"https:\/\/gp2.org\/wp-content\/uploads\/2022\/11\/102049-010_GP2Blogs_DataChart_3_v1r168-1-1.jpg 1024w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/11\/102049-010_GP2Blogs_DataChart_3_v1r168-1-1-300x230.jpg 300w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/11\/102049-010_GP2Blogs_DataChart_3_v1r168-1-1-768x589.jpg 768w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/11\/102049-010_GP2Blogs_DataChart_3_v1r168-1-1-256x196.jpg 256w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/11\/102049-010_GP2Blogs_DataChart_3_v1r168-1-1-512x393.jpg 512w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/11\/102049-010_GP2Blogs_DataChart_3_v1r168-1-1-939x720.jpg 939w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/> \u00a0 <span style=\"font-weight: 400;\">\u672a\u6765\u7684\u6570\u636e\u53d1\u5e03\u8fd8\u5c06\u7ee7\u7eed\u63d0\u9ad8\u53c2\u4e0e\u8005\u7684\u591a\u5143\u6027\u3002\u60a8\u53ef\u4ee5\u5728<strong><a href=\"\/cohort-dashboard-advanced\/\" rel=\"\">\u6211\u4eec\u7684Dashboard<\/a><\/strong>\u4e0a\u67e5\u770b\u6211\u4eec\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u8fd9\u4e2a\u6570\u636e\u96c6\u7684\u4e3b\u8981\u6210\u679c\u662f\u5305\u542b\u4e86\u66f4\u591a\u6837\u672c\uff0c\u5305\u62ec\u57fa\u4e8e\u9635\u5217\u7684\u548c\u63a8\u5b9a\u7684\u57fa\u56e0\u6570\u636e\uff0c\u4ee5\u53ca\u65b0\u589e\u7684\u4e34\u5e8a\u548c\u57fa\u56e0\u7ec4\u5143\u6570\u636e\u3002\u8be5\u6570\u636e\u5df2\u4f7f\u7528\u5b9a\u5236\u7684GP2\u57fa\u56e0\u578b\u805a\u7c7b\u6587\u4ef6\u8fdb\u884c\u4e86\u805a\u7c7b(\u53ef\u57281\u7ea7\u548c2\u7ea7\u6570\u636e\u8bbf\u95ee\u4e0b\u7684<b>utils<\/b><span style=\"font-weight: 400;\">\u76ee\u5f55\u4e2d\u67e5\u770b)\u3002\u8fd9\u4e2a\u805a\u7c7b\u6587\u4ef6\u662f\u57fa\u4e8e6\u4e2a\u8840\u7edf\u7ec4\u76842793\u4e2a\u6837\u672c\uff0c \u8fd9\u4e9b\u6837\u672c\u4ee3\u8868\u4e86\u7ec4\u6210\u8fd9\u6b21GP2\u6570\u636e\u53d1\u5e03\u7684\u4e0d\u540c\u9057\u4f20\u8840\u7edf\uff0c\u4ee5\u53ca420\u4e2a\u6208\u8c22\u75c5\u75c5\u4f8b\u7684\u5bcc\u96c6\uff0c\u4ee5\u66f4\u597d\u5730\u6355\u83b7<\/span><i><span style=\"font-weight: 400;\">GBA<\/span><\/i><span style=\"font-weight: 400;\">\u98ce\u9669\u57fa\u56e0\u4e2d\u7684\u76f8\u5173\u53d8\u4f53\u3002\u5982\u679c\u60a8\u5e0c\u671b\u5c06\u96c6\u7fa4\u6587\u4ef6\u5e94\u7528\u4e8eGP2\u4ee5\u5916\u7684\u6570\u636e\uff0c\u53ef\u901a\u8fc7<strong><a href=\"https:\/\/github.com\/GP2code\" target=\"_blank\" rel=\"noopener\">GP2 GitHub\u5b58\u50a8\u5e93<\/a> <\/strong><\/span><span style=\"font-weight: 400;\">\u4e0b\u8f7d\u8be5\u96c6\u7fa4\u6587\u4ef6<\/span>\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u6211\u4eec\u8fd8\u66f4\u65b0\u4e86\u6240\u6709\u901a\u8fc7\u8d28\u91cf\u63a7\u5236\u7684\u57fa\u56e0\u578b\u6837\u672c\u7684\u62f7\u8d1d\u6570\u53d8\u5f02\uff08CNV\uff09\u8c03\u7528\uff08\u57fa\u56e0\u7ea7\u52a0250kb\u4fa7\u7ffc\u533a\u57df\uff09\u3002CNV\u662f\u6307\u67d0\u6bb5DNA\u91cd\u590d\u6b21\u6570\u7684\u53d8\u5316\u3002\u8fd9\u79cd\u53d8\u5f02\u53ef\u80fd\u662f\u901a\u8fc7\u7f3a\u5931\u3001\u63d2\u5165\u6216\u5176\u5b83\u4e8b\u4ef6\u4ea7\u751f\u7684\uff0c\u5e76\u4e14\u53ef\u80fd\u63d0\u4f9b\u66f4\u591a\u5173\u4e8e\u7ed3\u6784\u53d8\u5f02\u5982\u4f55\u5f71\u54cd\u75be\u75c5\u98ce\u9669\u7684\u4fe1\u606f\u3002\u7528\u4e8e\u6982\u7387\u62f7\u8d1d\u6570\u53d8\u5f02(CNV)\u5206\u6790\u7684\u7ba1\u9053\u53ef\u5728<strong>GP2 <a href=\"https:\/\/github.com\/GP2code\" target=\"_blank\" rel=\"noopener\">Github<\/a><\/strong><\/span><span style=\"font-weight: 400;\">\u4e0a\u627e\u5230\u3002\u8fd9\u4e9b\u7ed3\u679c\u57282\u7ea7\u8bbf\u95ee\u5de5\u4f5c\u533a\u4e2d\u6309\u9057\u4f20\u8840\u7edf\u8fdb\u884c\u5206\u5c42\u3002\u8fd9\u4e9b\u6982\u7387CNV\u662f\u4e00\u4e2a\u5f88\u597d\u7684\u8d77\u70b9\uff0c\u53ef\u4ee5\u4f18\u5148\u8003\u8651\u643a\u5e26\u6f5c\u5728\u63d2\u5165\u3001\u7f3a\u5931\u6216\u91cd\u590d\u7684\u611f\u5174\u8da3\u7684\u57fa\u56e0\u7684\u6837\u672c\uff0c\u4ee5\u4fbf\u5f00\u5c55\u540e\u7eed\u7814\u7a76\u548c\u8fdb\u4e00\u6b65\u5206\u6790\u3002<\/span><\/span><\/p>\n<p><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u66f4\u591a\u5173\u4e8e\u590d\u6742\u75be\u75c5\u57fa\u56e0\u578b\u548c\u4e34\u5e8a\u6570\u636e\u8be6\u89c1\u9898\u4e3a<a href=\"https:\/\/gp2.org\/the-components-of-gp2-first-data-release\/\"><strong>\u201cGP2\u7b2c\u4e00\u6b21\u6570\u636e\u53d1\u5e03\u5185\u5bb9\u201d<\/strong><\/a>\u2019 <\/span><span style=\"font-weight: 400;\">\u7684\u535a\u5ba2\u6587\u7ae0\uff0cREADME\u683c\u5f0f\u5df2\u6839\u636e\u672c\u6b21\u53d1\u5e03\u66f4\u65b0\uff0c\u53ef\u5728GP2\u5b98\u65b9Terra\u5de5\u4f5c\u7a7a\u95f4\u4e2d\u53ef\u83b7\u53d6\u3002\u540c\u4e00\u4e2aREADME\u6587\u4ef6\u4e2d\u4e5f\u5305\u542b\u5355\u57fa\u56e0PD WGS\u6570\u636e\u7684\u8be6\u7ec6\u4fe1\u606f\u3002\u4e0b\u6b21\u53d1\u5e03\u5c06\u63d0\u4f9b\u66f4\u591a\u5355\u57fa\u56e0WGS\u6570\u636e\u3002<\/span><\/span><\/span><\/p>\n<p><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">\u4e0b\u6b21\u53d1\u5e03\u9884\u89c8\uff1a\uff08\u8ba1\u52122023\u5e74\u7b2c\u4e00\u5b63\u5ea6\u5047\u65e5\u5b63\u53d1\u5e03\uff09\uff1a<\/span><\/span><\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u66f4\u591a\u57fa\u56e0\u578b\u6570\u636e<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u66f4\u591aWGS\u6570\u636e<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u66f4\u591a\u4e34\u5e8a\u5143\u6570\u636e<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u6700\u65b0\u7684\u5206\u6790\u4ee3\u7801\u548c\u5de5\u5177<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u66f4\u591a\u5173\u4e8e\u98ce\u9669\u548c\u53d1\u75c5\u5e74\u9f84GWAS\u7814\u7a76\u7684\u6c47\u603b\u7edf\u8ba1\u6570\u636e<\/span><\/li>\n<\/ul>\n<hr \/>\n<p>\u672c\u7bc7\u535a\u6587\u7531<strong><a href=\"https:\/\/gp2.org\/working-groups\/complex-disease-data-analysis-working-group\/\" rel=\"\">GP2\u590d\u6742\u75be\u75c5\u6570\u636e\u5206\u6790\u5de5\u4f5c\u7ec4\u6210\u5458\u64b0\u5199<\/a><\/strong>\uff1aHampton Leonard\u3001Mike Nalls\u3001Dan Vitale\u548cMary Makarious\uff1b\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684Matthew Korestsky\uff1bData Tecnica International\u516c\u53f8\/\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684Kristin Levine\uff1b\u4ee5\u53ca<a href=\"https:\/\/gp2.org\/working-groups\/monogenic-data-analysis-working-group\/\" rel=\"\"><strong>\u5355\u57fa\u56e0-\u6570\u636e\u5206\u6790\u5de5\u4f5c\u7ec4<\/strong><\/a>\u6210\u5458Zih-Hua Fang\u548cPeter Heutink<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2022\u5e744\u6708\uff0cGP2\u4e0eAMP<sup>\u00ae<\/sup> PD\u4e00\u8d77\u5728Terra\u5e73\u53f0\u8fdb\u884c\u4e86\u7b2c\u4e8c\u6b21\u6570\u636e\u53d1\u5e03\u3002\u672c\u6b21\u53d1\u5e03\u5305\u542b\u4e86\u5927\u91cf\u7684\u65b0\u6570\u636e\u548c\u65b0\u8d44\u6e90\uff0c\u6837\u672c\u6570\u91cf\u51e0\u4e4e\u662f\u4e0a\u6b21\u53d1\u5e03\u7684\u4e24\u500d\u3002\u00a0<\/p>\n","protected":false},"author":0,"featured_media":50024740,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50011961","post","type-post","status-publish","format-standard","hentry","post-type-723","post-type-743","post-type-724","topic-research-operations-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50011961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/comments?post=50011961"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50011961\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media\/50024740"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media?parent=50011961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}