{"id":50011912,"date":"2022-01-10T07:57:06","date_gmt":"2022-01-10T12:57:06","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/gp2%e7%ac%ac%e4%b8%80%e6%ac%a1%e6%95%b0%e6%8d%ae%e5%8f%91%e5%b8%83%e5%86%85%e5%ae%b9\/"},"modified":"2024-10-21T15:12:10","modified_gmt":"2024-10-21T19:12:10","slug":"gp2%e7%ac%ac%e4%b8%80%e6%ac%a1%e6%95%b0%e6%8d%ae%e5%8f%91%e5%b8%83%e5%86%85%e5%ae%b9","status":"publish","type":"post","link":"https:\/\/gp2.org\/zh-hans\/gp2%e7%ac%ac%e4%b8%80%e6%ac%a1%e6%95%b0%e6%8d%ae%e5%8f%91%e5%b8%83%e5%86%85%e5%ae%b9\/","title":{"rendered":"GP2\u7b2c\u4e00\u6b21\u6570\u636e\u53d1\u5e03\u5185\u5bb9"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">2021\u5e7412\u6708GP2\u5ba3\u5e03\u5728 <\/span><a href=\"https:\/\/amp-pd.org\/register-for-amp-pd\" target=\"_blank\" rel=\"noopener\"><strong>AMP\u00ae<\/strong><span style=\"font-weight: 400;\"><strong> PD\u5e73\u53f0<\/strong><\/span><\/a><span style=\"font-weight: 400;\">\u4e0a\u8fdb\u884c\u9996\u6b21\u6570\u636e\u53d1\u5e03\u3002\u53d1\u5e03\u7684\u6570\u636e\u5305\u62ec\u6765\u81ea\u79d1\u91cc\u8036\u5c14\u533b\u5b66\u7814\u7a76\u6240\uff08CORIELL\uff09\u3001\u8d1d\u52d2\u533b\u5b66\u9662 (BCM) \u548c BCM-\u9a6c\u91cc\u5170\u5927\u5b66 (UMD)\u961f\u5217\u7684 4908 \u540d\u53c2\u4e0e\u8005\uff083434\u540d PD\uff0c1474\u540d\u975e PD\uff09\u3002GP2\u6570\u636e\u53d1\u5e03\u7684\u53c2\u4e0e\u8005\u6839\u636e\u4ed6\u4eec\u57fa\u56e0\u51b3\u5b9a\u7684\u7956\u5148(GDA)\u5206\u4e3a\u516b\u4e2a\u7956\u5148\u7ec4\uff1b\u4e0b\u8868\u8be6\u7ec6\u4ecb\u7ecd\u4e86 GP2 \u9996\u6b21\u6570\u636e\u53d1\u5e03\u4e2d\u53c2\u4e0e\u8005\u7684\u57fa\u56e0\u51b3\u5b9a\u7684\u7956\u5148\u4fe1\u606f\u3002<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21434 aligncenter\" src=\"https:\/\/gp2.org\/wp-content\/uploads\/2021\/12\/ancestry-table-1024x641.jpg\" alt=\"\" width=\"600\" height=\"376\" \/> <span style=\"font-weight: 400;\">\u672a\u6765\u7684\u6570\u636e\u53d1\u5e03\u8fd8\u5c06\u7ee7\u7eed\u63d0\u9ad8\u53c2\u4e0e\u8005\u7684\u591a\u5143\u6027\u3002\u60a8\u53ef\u4ee5\u5728<\/span><a href=\"https:\/\/gp2.org\/cohort-dashboard\/\" rel=\"\"><span style=\"font-weight: 400;\"><strong>\u6211\u4eec\u7684Dashboard<\/strong><\/span><\/a><span style=\"font-weight: 400;\">\u4e0a\u67e5\u770b\u6211\u4eec\u7684\u8fdb\u5c55\u3002<\/span><\/span><\/p>\n<h3>\u57fa\u56e0\u578b<\/h3>\n<p><span style=\"font-weight: 400;\">\u6240\u6709\u6570\u636e\u5747\u5728Illumina NeuroBooster Array\u4e0a\u8fdb\u884c\u57fa\u56e0\u5206\u578b\uff0c\u8be5\u9635\u5217\u4e13\u4e3a\u4e0d\u540c\u4eba\u7fa4\u4e2d\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u53d8\u5f02\u800c\u8bbe\u8ba1\u3002\u6570\u636e\u6839\u636e\u6807\u51c6Illumina\u534f\u8bae\u8fdb\u884c\u5904\u7406\uff0c\u6570\u636e\u7684\u8d28\u91cf\u63a7\u5236\u7531GP2\u7528\u6211\u4eec\u7684\u5f00\u6e90QC\u7ba1\u9053\u8fdb\u884c\u5904\u7406\u3002\u7136\u540e\u5728\u6bcf\u4e2a\u7684\u7956\u5148\u7ec4\u4e2d\u4f7f\u7528TOPMed\u8fdb\u884c\u6570\u636e\u586b\u8865\u3002\u6240\u6709\u5df2\u77e5\u7684\u91cd\u590d\u6570\u636e\u90fd\u88ab\u5220\u9664\uff0c\u4f46\u76f8\u5173\u7684\u6837\u672c\u4ecd\u4e88\u4ee5\u4fdd\u7559\uff0c\u4ee5\u4fc3\u8fdb\u793e\u533a\u5206\u6790\u7684\u7075\u6d3b\u6027\u3002<\/span> <span style=\"font-weight: 400;\">\u5982\u679c\u60a8\u60f3\u4e86\u89e3QC\u7ba1\u9053\u7684\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u5173\u6ce8<strong><a href=\"https:\/\/github.com\/GP2code\/GenoTools\" target=\"_blank\" rel=\"noopener\">GitHub\u9875\u9762<\/a><\/strong><\/span>\u4e0a\u8be6\u5c3d\u7684\u5de5\u4f5c\u6d41\u7a0b\u3002<\/p>\n<h3>\u4e34\u5e8a\u6570\u636e<\/h3>\n<p><span style=\"font-weight: 400;\">\u534f\u8c03\u4e34\u5e8a\u6570\u636e\uff0c\u4ee5\u5f62\u6210\u7edf\u4e00\u7684GP2\u4e34\u5e8a\u6570\u636e\u96c6\u3002\u5bf9\u4e34\u5e8a\u6570\u636e\u7684\u6700\u4f4e\u8981\u6c42\u5305\u62ec\u4eba\u53e3\u7edf\u8ba1\u7279\u5f81\u3001\u62db\u52df\u7c7b\u522b\u548c\u5bb6\u65cf\u53f2\u3002<\/span><span style=\"font-weight: 400;\"> \u5982\u679c\u60a8\u60f3\u8fdb\u4e00\u6b65\u4e86\u89e3GP2\u6838\u5fc3\u6570\u636e\u96c6\u8981\u6c42<\/span><span style=\"font-weight: 400;\">\uff0c\u8bf7\u53c2\u8003<\/span><span style=\"font-weight: 400;\"><strong><a title=\"\u8d44\u6e90\" href=\"\/resources\/\" rel=\"\">\u6211\u4eec\u7f51\u7ad9\u7684\u4e2d\u7684\u201c<\/a><a href=\"https:\/\/gp2.org\/wp-content\/uploads\/sites\/2\/2020\/10\/GP2_Cohort_clinical-data-core-data-set_table_October2020-1.pdf\" target=\"_blank\" rel=\"noopener\">\u4e34\u5e8a\u6570\u636e\u6838\u5fc3\u6570\u636e\u96c6<\/a><a title=\"\u8d44\u6e90\" href=\"\/resources\/\" rel=\"\">\u201d \u6587\u4ef6<\/a><\/strong>\u3002<\/span><span style=\"font-weight: 400;\">\u6570\u636e\u5c06\u901a\u8fc7<strong><a href=\"https:\/\/app.terra.bio\/#\" target=\"_blank\" rel=\"noopener\">Terra\u5e73\u53f0<\/a><\/strong>\u8bbf\u95ee\u3002\u00a0<\/span> <span style=\"font-weight: 400;\">\u5982\u679c\u60a8\u60f3\u4e86\u89e3\u5982\u4f55\u8bbf\u95eeGP2\u6570\u636e\uff0c\u8bf7\u9605\u8bfb\u6211\u4eec\u7684\u535a\u6587\u300a<\/span><strong><a href=\"https:\/\/gp2.org\/applying-for-gp2-data-access-on-the-amp-pd-platform\/\" rel=\"\">\u7533\u8bf7\u5728AMP\u00ae PD\u5e73\u53f0\u4e0a\u8bbf\u95eeGP2\u6570\u636e <\/a><\/strong><span style=\"font-weight: 400;\">\u300b\u3002\u60a8\u53ef\u4ee5\u5728Terra\u4e0a\u627e\u5230GP2\u9996\u6b21\u6570\u636e\u53d1\u5e03\u4e2d\u7684\u4ee5\u4e0b\u7684\u6570\u636e\u4ea7\u54c1\uff1a<\/span><\/p>\n<ul>\n<li><b>\u7b2c\u4e00\u5c42\u6570\u636e\u8bbf\u95ee<\/b><b> <\/b>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u6700\u65b0\u7684\u5e15\u91d1\u68ee\u75c5 GWAS \u7684\u6c47\u603b\u7edf\u8ba1\u6570\u636e\uff08\u4e0d\u5305\u62ec\u6765\u81ea<strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31701892\/\" target=\"_blank\" rel=\"noopener\">Nalls et al.2019<\/a><\/strong>\u768423andMe\u6837\u672c\uff09\u3002<\/span><\/li>\n<\/ul>\n<\/li>\n<li><b>\u7b2c\u4e8c\u5c42\u6570\u636e\u8bbf\u95ee<\/b><b> <\/b>\n<ul>\n<li><span style=\"font-weight: 400;\"><em>\u539f\u59cb\u57fa\u56e0\u578b\uff1a<\/em>\u4e3a\u4e86\u5728\u586b\u8865\u4e4b\u524d\u8ba9\u6240\u6709\u6837\u672c\u901a\u8fc7\u8d28\u91cf\u63a7\u5236\uff0c\u6bcf\u4e2a\u7956\u5148\u7ec4\u7684PLINK2 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400;\">\u6211\u4eec\u5e0c\u671b\u8fd9\u80fd\u6210\u4e3a\u5e15\u91d1\u68ee\u75c5\u7814\u7a76\u754c\u7684\u4e00\u4e2a\u5b9d\u8d35\u8d44\u6e90\u3002<\/span>\u6211\u4eec\u8fd8\u5728\u4e0d\u65ad\u5730\u4f18\u5316\u6211\u4eec\u7684\u6d41\u7a0b\uff0c\u672a\u6765\u8fd8\u4f1a\u4e3a\u5927\u5bb6\u5e26\u6765\u66f4\u591a\u60ca\u559c\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-50009864 aligncenter\" src=\"https:\/\/gp2.org\/wp-content\/uploads\/2022\/01\/GP2_round1_projected_pcs-1024x621.png\" alt=\"\" width=\"1024\" height=\"621\" srcset=\"https:\/\/gp2.org\/wp-content\/uploads\/2022\/01\/GP2_round1_projected_pcs-1024x621.png 1024w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/01\/GP2_round1_projected_pcs-300x182.png 300w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/01\/GP2_round1_projected_pcs-768x466.png 768w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/01\/GP2_round1_projected_pcs-256x155.png 256w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/01\/GP2_round1_projected_pcs-512x310.png 512w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/01\/GP2_round1_projected_pcs-1188x720.png 1188w, https:\/\/gp2.org\/wp-content\/uploads\/2022\/01\/GP2_round1_projected_pcs.png 1275w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<p>\u672c\u535a\u6587\u7531Hampton Leonard\u3001Mike Nalls\u3001Yeajin Song\u548cDan Vitale\u5171\u540c\u64b0\u5199\u3002\u8bf7\u8bbf\u95eeGP2\u7684<span style=\"font-weight: 400;\">\u590d\u6742\u75be\u75c5-\u6570\u636e\u5206\u6790\u5de5\u4f5c\u7ec4<\/span>\u9875\u9762\u4e86\u89e3\u4f5c\u8005\u7684\u80cc\u666f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fdb\u4e00\u6b65\u4e86\u89e3\u5982\u4f55\u83b7\u5f97\u57fa\u56e0\u578b\u548c\u4e34\u5e8a\u6570\u636e\uff0c\u4ee5\u53ca\u5df2\u6709\u7684\u4e0d\u540c\u7684\u6570\u636e\u8bbf\u95ee\u5c42\u3002<\/p>\n","protected":false},"author":0,"featured_media":50024762,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50011912","post","type-post","status-publish","format-standard","hentry","post-type-723","post-type-743","post-type-724","topic-research-operations-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50011912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/comments?post=50011912"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50011912\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media\/50024762"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media?parent=50011912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}