{"id":50011862,"date":"2021-05-24T20:26:04","date_gmt":"2021-05-25T00:26:04","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/%e4%ba%86%e8%a7%a3%e5%85%a8%e5%9f%ba%e5%9b%a0%e7%bb%84%e5%85%b3%e8%81%94%e7%a0%94%e7%a9%b6%ef%bc%88gwas%ef%bc%89%ef%bc%9a%e7%ac%ac%e4%ba%8c%e9%83%a8%e5%88%86-%e6%9b%b4%e5%a4%9a%e8%a7%81%e8%a7%a3\/"},"modified":"2024-10-21T15:05:45","modified_gmt":"2024-10-21T19:05:45","slug":"%e4%ba%86%e8%a7%a3%e5%85%a8%e5%9f%ba%e5%9b%a0%e7%bb%84%e5%85%b3%e8%81%94%e7%a0%94%e7%a9%b6%ef%bc%88gwas%ef%bc%89%ef%bc%9a%e7%ac%ac%e4%ba%8c%e9%83%a8%e5%88%86-%e6%9b%b4%e5%a4%9a%e8%a7%81%e8%a7%a3","status":"publish","type":"post","link":"https:\/\/gp2.org\/zh-hans\/%e4%ba%86%e8%a7%a3%e5%85%a8%e5%9f%ba%e5%9b%a0%e7%bb%84%e5%85%b3%e8%81%94%e7%a0%94%e7%a9%b6%ef%bc%88gwas%ef%bc%89%ef%bc%9a%e7%ac%ac%e4%ba%8c%e9%83%a8%e5%88%86-%e6%9b%b4%e5%a4%9a%e8%a7%81%e8%a7%a3\/","title":{"rendered":"\u4e86\u89e3\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\uff1a\u7b2c\u4e8c\u90e8\u5206-\u66f4\u591a\u89c1\u89e3\u548c\u6280\u5de7\uff1a"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">\u5728\u4e0a\u4e00\u7bc7 <\/span><a href=\"https:\/\/gp2.org\/understanding-gwas\/\"><span style=\"font-weight: 400;\">\u535a\u6587<\/span><\/a><span style=\"font-weight: 400;\">\u91cc\uff0c\u6211\u4eec\u4ecb\u7ecd\u4e86\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\uff0c\u5305\u62ec\u5176\u7edf\u8ba1\u516c\u5f0f\u3001\u5de5\u4f5c\u6d41\u7a0b\u4ee5\u53ca\u6700\u65b0\u7684\u5e15\u91d1\u68ee\u75c5GWAS\u5b9e\u4f8b\u3002\u4eca\u5929\u4ecb\u7ecd\u66f4\u591a\u7684\u89c1\u89e3\u548c\u6280\u5de7\uff0c\u4f9b\u60a8\u5728\u8fd0\u884c\u60a8\u81ea\u5df1\u7684GWAS\u65f6\u53c2\u8003\u3002<\/span><\/p>\n<p><b>\u8d28\u91cf\u63a7\u5236\u548c\u4f30\u7b97\u8fc7\u7a0b<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u4f4e\u7f3a\u5931\uff08\u4f18\u5148\u9009\u62e9\u6bcf\u4e2a\u6837\u672c\u548c\u6bcf\u4e2aSNP&lt;1%\u7684\uff09\u7684\u9ad8\u8d28\u91cf\u57fa\u56e0\u578b\uff08\u975e\u56de\u6587\uff0c\u5373\u5982\u679c\u53ef\u80fd\u7684\u8bdd\uff0c\u6ca1\u6709 A\/T\uff0cG\/C\uff0c\u5177\u6709\u8868\u660e\u96c6\u7fa4\u8d28\u91cf\u7684\u9ad8Illumina Gentrain\u5206\u6570\uff09\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u901a\u5e38\u5173\u6ce8\u5e38\u89c1\u7684\u3001\u6b21\u8981\u7684&gt;1%\u7684\u7b49\u4f4d\u57fa\u56e0\u9891\u7387\uff0c\u4f4e\u4e8e\u6b64\u503c\u5219\u5e0c\u671b\u57fa\u56e0\u578b\u7c07\u770b\u8d77\u6765\u5f88\u597d\uff08\u8bb0\u5f97\u68c0\u67e5\uff09\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u68c0\u67e5\u6837\u54c1\u662f\u5426\u5b58\u5728\u9ad8\u6742\u5408\u7387\uff0c\u56e0\u4e3a\u8fd9\u53ef\u80fd\u8868\u660e\u5b58\u5728\u6f5c\u5728\u6c61\u67d3\u3002\u6742\u5408\u7387\u8fc7\u4f4e\u4e5f\u53ef\u80fd\u662f\u4e2a\u95ee\u9898\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u6ce8\u610f\u91cd\u590d\u7684\u6837\u672c\u548c\u5173\u8054\u673a\u5236\u4e0d\u660e\u7684\u6837\u672c\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u901a\u8fc7\u9057\u4f20\u7956\u5148\u7b97\u6cd5\u786e\u5b9a\u548c\u89e3\u6790\u6837\u672c\uff08\u6211\u4eec\u4f7f\u7528<\/span><a href=\"https:\/\/rajanil.github.io\/fastStructure\/\"><span style=\"font-weight: 400;\">fastStructure <\/span><\/a><span style=\"font-weight: 400;\">\u548c<\/span><a href=\"https:\/\/github.com\/gabraham\/flashpca\"><span style=\"font-weight: 400;\">flashPCA<\/span><\/a><span style=\"font-weight: 400;\">\u7684\u7ec4\u5408\uff09\u3002\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u591a\u6837\u6027\uff0c\u4f46\u8981\u8b66\u60d5\u7fa4\u4f53\u5b50\u7ed3\u6784\u53ca\u5176\u5bf9\u5206\u6790\u7ed3\u679c\u7684\u5f71\u54cd\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u67e5\u770b\u5e76\u975e\u5076\u7136\u7f3a\u5931\u7684SNP\uff0c\u5305\u62ec\u56e0\u7f3a\u5931\u5bfc\u81f4\u7684\u504f\u89c1\uff1a\u5bf9\u7167\u72b6\u6001\u6216\u5355\u500d\u578b\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u60a8\u5b8c\u5168\u53ef\u4ee5\u5bf9\u5355\u4e2a\u7fa4\u4f53\u4f7f\u7528\u591a\u4e2a\u63d2\u8865\u53c2\u8003\u9762\u677f\uff0c\u5e76\u4f7f\u7528\u7531\u6b64\u5f97\u5230\u7684\u5177\u6709\u6700\u4f73\u8d28\u91cf\u6307\u6807\u7684\u57fa\u56e0\u578b\u3002\u8fd9\u5728\u6df7\u5408\u6837\u672c\u7fa4\u4f53\u4e2d\u7279\u522b\u6709\u7528\u3002<\/span><\/li>\n<\/ul>\n<p><b>\u7814\u7a76\u7ea7\u522b\u5206\u6790\u8d34\u58eb<\/b><b> <\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u56de\u5f52-GWAS\u901a\u5e38\u5bf9\u8fde\u7eed\u7ed3\u679c\u4f7f\u7528\u7ebf\u6027\u56de\u5f52\u6a21\u578b\uff0c\u5bf9\u79bb\u6563\u7ed3\u679c\u4f7f\u7528\u903b\u8f91\u56de\u5f52\u6a21\u578b\u3002\u8fd9\u5c31\u91cf\u5316\u4e86SNP\u7684\u98ce\u9669\uff0c\u540c\u65f6\u8003\u8651\u4e86\u534f\u53d8\u91cf\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u591a\u79cd\u8f6f\u4ef6\u5305\u53ef\u7528\u4e8e\u8fd0\u884c\u6df7\u5408\u7ebf\u6027\u6a21\u578b\uff0c\u8fd9\u4e9b\u6a21\u578b\u53ef\u4ee5\u51c6\u786e\u5730\u8bf4\u660e\u76f8\u5173\u6027\u548c\u7cbe\u7ec6\u7684\u4eba\u53e3\u5b50\u7ed3\u6784\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">PCs-\u57fa\u4e8e\u5168\u57fa\u56e0\u7ec4\u57fa\u56e0\u5206\u578b\u6570\u636e\uff0c\u8ba1\u7b97\u4e3b\u6210\u5206\u8d1f\u8377\uff0c\u4e3a\u60a8\u7684\u56de\u5f52\u6a21\u578b\u63d0\u4f9b\u4e00\u7ec4\u6709\u7528\u7684\u534f\u53d8\u91cf\uff0c\u8ba9\u60a8\u6709\u6548\u5730\u8003\u8651\u4eba\u53e3\u5b50\u7ed3\u6784\u3002<\/span><\/li>\n<\/ul>\n<p><b>\u73b0\u5728\u8ba9\u6211\u4eec\u6765\u8fdb\u884c\u5143\u5206\u6790\u3002<\/b><b> <\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u56fa\u5b9a\u4e0e\u968f\u673a\u2014\u2014\u8fd9\u4e9b\u662f\u5143\u5206\u6790\u65b9\u6cd5\uff0c\u7528\u4e8e\u8de8\u6570\u636e\u5b64\u5c9b\u548c\/\u6216\u51fa\u7248\u7269\u5408\u5e76\u6570\u636e\u5728\u6c47\u603b\u7edf\u8ba1\u7ea7\u522b\u5408\u5e76\u6570\u636e\u3002\u56fa\u5b9a\u6548\u5e94\u5143\u5206\u6790\u901a\u5e38\u5bf9\u53d1\u73b0\u5206\u6790\u5f88\u6709\u7528\uff0c\u800c\u4e14\u901a\u5e38\u66f4\u5f3a\u5927\uff0c\u5c3d\u7ba1\u6211\u4eec\u4e2d\u7684\u4e00\u4e9b\u4eba\u66f4\u559c\u6b22\u968f\u673a\u6548\u5e94\u6a21\u578b\uff0c\u56e0\u4e3a\u540e\u8005\u66f4\u4fdd\u5b88\uff0c\u5e76\u4e14\u53ef\u4ee5\u89e3\u91ca\u6570\u636e\u5b64\u5c9b\u4e4b\u95f4\u7684\u5f02\u8d28\u6027\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u5f02\u8d28\u6027\u4f30\u8ba1\u2014\u2014\u901a\u5e38\u8868\u793a\u4e3aCochrane\u7684Q\u6216I2\u3002\u8fd9\u5f88\u91cd\u8981\uff0c\u80fd\u8ba9\u6211\u4eec\u4e00\u7aa5\u79bb\u7fa4\u6548\u5e94\u504f\u5dee\u548c\u7ed3\u679c\u7684\u666e\u904d\u6027\u3002<\/span><\/li>\n<\/ul>\n<p><b>\u5ba1\u67e5\u7ed3\u679c<\/b><b> <\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u7814\u7a76\u7ea7\u522b\u62c9\u59c6\u8fbe-\u5c06\u5176\u4fdd\u6301\u57280.95\u548c1.05\u4e4b\u95f4\uff0c\u8d85\u51fa\u8fd9\u4e00\u533a\u95f4\u90fd\u4f1a\u6709\u95ee\u9898\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u603b\u4f53\u62c9\u59c6\u8fbe\u548c\u62c9\u59c6\u8fbe1000\u2014\u2014\u5f53\u5bf9\u7167\u7814\u7a76\u4e0d\u5e73\u8861\u65f6\uff0c\u5728\u7814\u7a76\u7ea7\u522b\u6216\u5143\u5206\u6790\u7ea7\u522b\u8ba1\u7b97\u62c9\u59c6\u8fbe\u53ef\u80fd\u4f1a\u5f88\u68d8\u624b\u3002\u5927\u91cf\u8fc7\u91cf\u7684\u63a7\u5236\u4f1a\u4eba\u4e3a\u5730\u62c9\u9ad8\u62c9\u59c6\u8fbe\u7edf\u8ba1\u91cf\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u8bf7\u4f7f\u7528\u62c9\u59c6\u8fbe1000\uff0c\u56e0\u4e3a\u5b83\u6269\u5c55\u5230\u4e86 1000\u4e2a\u6848\u4f8b\u548c1000\u4e2a\u3002\u518d\u6b21\u63d0\u9192\uff0c\u6b64\u5bf9\u7167\u7ec4\u4ee3\u7801\u5728\u6211\u4eec\u7684GitHub\u5b58\u50a8\u5e93\u4e2d\u53ef\u4ee5\u627e\u5230\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u8fde\u9501\u4e0d\u5e73\u8861\uff08LD\uff09\u5f97\u5206\u622a\u8ddd-\u62c9\u59c6\u8fbe\u7684\u66ff\u4ee3\/\u8865\u5145\uff0c\u5bf9 LD \u7ed3\u6784\u548c\u5bf9\u7167\u7814\u7a76\u4e0d\u5e73\u8861\u66f4\u52a0\u7a33\u5065<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u56fe\u4e2d\u663e\u793a\u5747\u5300\u6027\u7684LD\u5cf0\u503c\u2014\u2014\u8fd9\u975e\u5e38\u7b80\u5355\uff0c\u7ed8\u5236\u65f6\u7684\u7ed3\u679c\u5e94\u8be5\u770b\u8d77\u6765\u50cf\u66fc\u54c8\u987f\u7684\u5854\uff08\u6216\u662f\u60a8\u9009\u62e9\u7684\u57ce\u5e02\uff0c\u5bf9\u4e0d\u8d77\u4e86\u534e\u76db\u987f\uff09\uff0c\u800c\u4e0d\u662f\u50cf\u66b4\u98ce\u96ea\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u590d\u5236\u2014\u2014\u603b\u662f\u597d\u7684\uff0c\u4f46\u6709\u65f6\u4f60\u6ca1\u6709\u53ef\u7528\u7684\u6570\u636e\u96c6\u3002\u5f53\u65e0\u6cd5\u83b7\u5f97\u989d\u5916\u6570\u636e\u65f6\uff0c\u5c1d\u8bd5\u7ed3\u5408\u4f7f\u7528\u7559\u4e00\u6cd5\u835f\u8403\u5206\u6790\u548c\u4ea4\u53c9\u9a8c\u8bc1\u3002<\/span><\/li>\n<\/ul>\n<p><b>\u4e00\u4e9b\u540eGWAS\u5206\u6790<\/b><b> <\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u6216\u8005\u8bf4\u201c\u5b8c\u6210GWAS\u5143\u5206\u6790\u540e\u8981\u505a\u4ec0\u4e48\uff1f\u201d\u8bf7\u6ce8\u610f\uff0cGP2\u540e\u7eed\u4f1a\u5c31\u8fd9\u4e9b\u8bdd\u9898\u63d0\u4f9b\u66f4\u591a\u7684\u535a\u6587\u548c\u8bfe\u7a0b\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u6761\u4ef6\u5206\u6790\u2014\u2014\u4f7f\u7528\u533a\u57df\u4e2d\u6700\u91cd\u8981\u7684SNP\u4f5c\u4e3a\u534f\u53d8\u91cf\uff0c\u5e76\u518d\u6b21\u8fdb\u884c\u5206\u6790\u6216\u4f7f\u7528<\/span><a href=\"https:\/\/cnsgenomics.com\/software\/gcta\/#Overview\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GCTA<\/span><\/a><span style=\"font-weight: 400;\">\u7b49\u5de5\u5177\u3002\u6bcf\u4e2a\u57fa\u56e0\u5ea7\u53ef\u80fd\u6709\u591a\u4e2a\u72ec\u7acb\u7684\u4fe1\u53f7\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u7cbe\u7ec6\u6620\u5c04\u2014\u2014\u8fd9\u53ef\u4ee5\u901a\u8fc7}<span style=\"font-weight: 400;\">\u5305\u62ec\u8d1d\u53f6\u65af\u5171\u5b9a\u4f4d\uff08\u5229\u7528\u57fa\u56e0\u7ec4\u53c2\u8003\u6570\u636e\u8fdb\u884c\u57fa\u56e0\u8868\u8fbe\u6216\u7c7b\u4f3c\u6307\u6807\uff09<\/span>\u7684\u8bf8\u5982<a href=\"https:\/\/github.com\/chr1swallace\/coloc\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">coloc <\/span><\/a>\u7684\u8f6f\u4ef6\u5305<\/span>\u4e2d\u7684\u8fd1\u4f3c\u8d1d\u53f6\u65af\u56e0\u5b50\u5206\u6790\u6765\u5b8c\u6210\u3002<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u9884\u6d4b\u6743\u91cd\u548cTWAS\u2014\u2014\u6709\u5f88\u591a\u4e0d\u540c\u7684\u8f6f\u4ef6\u5305\u53ef\u5229\u7528\u57fa\u56e0\u8868\u8fbe\u3001\u7532\u57fa\u5316\u6216\u67d3\u8272\u8d28\u7814\u7a76\u7b49\u5916\u90e8\u6743\u91cd\u6765\u8bc6\u522b\u9690\u85cf\u5728GWAS\u6570\u636e\u4e2d\u7684\u5047\u5b9a\u673a\u68b0\u8fde\u63a5\u57fa\u56e0\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ML\u2014\u2014\u4e13\u95e8\u6784\u5efa\u7684\u9884\u6d4b\uff0c\u6211\u4eec\u6700\u559c\u6b22\u7684\u8f6f\u4ef6\u5305\u662f <\/span><a href=\"https:\/\/genoml.github.io\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GenoML <\/span><\/a><span style=\"font-weight: 400;\">\uff0c\u56e0\u4e3a\u5b83\u57fa\u672c\u5b9e\u73b0\u4e86\u81ea\u52a8\u5316\uff0c\u8ba9\u57fa\u56e0\u7ec4\u5b66\u4e2d\u7684\u673a\u5668\u5b66\u4e60\uff08ML\uff09\u53d8\u5f97\u5bb9\u6613\u3002<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u5982\u6b32\u83b7\u53d6\u66f4\u591a\u4fe1\u606f\uff0c\u53ef\u5728 <\/span><a href=\"https:\/\/github.com\/GP2code\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GP2 GitHub<\/span><\/a><span style=\"font-weight: 400;\">\u4e0a\u627e\u5230\u6211\u4eec\u7684\u4ee3\u7801\u548c\u6d41\u6c34\u7ebf\u3002<\/span><\/p>\n<p>\u672c\u535a\u6587\u7531Hampton Leonard\u3001Mike Nalls\u3001Yeajin Song\u548cDan Vitale\u5171\u540c\u64b0\u5199\u3002\u8bf7\u8bbf\u95eeGP2\u7684<a href=\"\/working-groups\/complex-disease-data-analysis-working-group\/\">\u590d\u6742\u75be\u75c5-\u6570\u636e\u5206\u6790\u5de5\u4f5c\u7ec4<\/a>\u9875\u9762\u4e86\u89e3\u4f5c\u8005\u7684\u80cc\u666f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4f5c\u4e3a\u4e0a\u4e00\u7bc7\u4ecb\u7ecdGWAS\u535a\u6587\u7684\u540e\u7eed\uff0c\u590d\u6742\u75be\u75c5-\u6570\u636e\u5206\u6790\u5de5\u4f5c\u7ec4\u5728\u6b64\u6587\u4e2d\u4e3a\u60a8\u5982\u4f55\u8fd0\u884c\u60a8\u81ea\u5df1\u7684GWAS\u63d0\u4f9b\u4e86\u5b9e\u7528\u7684\u6280\u5de7\u548c\u89c1\u89e3\u3002<\/p>\n","protected":false},"author":0,"featured_media":50019560,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50011862","post","type-post","status-publish","format-standard","hentry","post-type-723","topic-complex-disease-genetics-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50011862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/comments?post=50011862"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50011862\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media\/50019560"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media?parent=50011862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}