{"id":50011825,"date":"2020-12-02T23:51:15","date_gmt":"2020-12-03T04:51:15","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e9%81%97%e4%bc%a0%e5%ad%a6%ef%bc%9a%e7%97%85%e5%9b%a0%e3%80%81%e9%a3%8e%e9%99%a9%e6%88%96%e4%bf%9d%e6%8a%a4%ef%bc%9f\/"},"modified":"2024-10-21T15:00:48","modified_gmt":"2024-10-21T19:00:48","slug":"%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e9%81%97%e4%bc%a0%e5%ad%a6%ef%bc%9a%e7%97%85%e5%9b%a0%e3%80%81%e9%a3%8e%e9%99%a9%e6%88%96%e4%bf%9d%e6%8a%a4%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/gp2.org\/zh-hans\/%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e9%81%97%e4%bc%a0%e5%ad%a6%ef%bc%9a%e7%97%85%e5%9b%a0%e3%80%81%e9%a3%8e%e9%99%a9%e6%88%96%e4%bf%9d%e6%8a%a4%ef%bc%9f\/","title":{"rendered":"\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u5b66\uff1a\u75c5\u56e0\u3001\u98ce\u9669\u6216\u4fdd\u62a4\uff1f"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">1996\u5e746\u6708\uff0c\u7ef4\u4e5f\u7eb3\u7687\u5bab-\u56fd\u9645\u5e15\u91d1\u68ee\u4e0e\u8fd0\u52a8\u969c\u788d\u5b66\u4f1a\u4e16\u754c\u5e74\u4f1a\u7684\u4e3e\u529e\u5730\u3002L. Golbe\u6559\u6388\u5411\u9707\u60ca\u7684\u89c2\u4f17\u5c55\u793a\u4e86\u610f\u5927\u5229\u5357\u90e8\u7f8e\u4e3d\u7684\u574e\u5e15\u5c3c\u4e9a\u5730\u533a\u7684\u7167\u7247\uff0c\u4ed6\u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u521a\u521a\u5728\u8be5\u5730\u533a\u53d1\u73b0\u4e86\u4e00\u4e2a\u5927\u5bb6\u65cf\u91cc\u6709\u5f88\u591a\u4eba\u60a3\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\uff0c\u5373\u6240\u8c13\u7684\u201c 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400;\">1997\u5e74\uff0cContursi\u8840\u7edf\u4e2d\u7684\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u4e5f\u88ab\u53d1\u73b0\uff0c\u4ec5\u4ec5\u4e00\u5e74\u540e\uff0c\u65e5\u672c\u4e5f\u53d1\u73b0\u4e86\u53d1\u75c5\u5f88\u65e9\u7684\u5e15\u91d1\u68ee\u5bb6\u65cf\u3002\u968f\u540e\u53d1\u73b0\u4e86\u5176\u5b83\u7684\u6bd4\u8f83\u786e\u5b9a\u7684\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u5728\u7a81\u53d8\u65f6\u53ef\u5bfc\u81f4PD (<\/span><i><span style=\"font-weight: 400;\">LRRK2<\/span><\/i><span style=\"font-weight: 400;\">\u3001<\/span><i><span style=\"font-weight: 400;\">VPS35<\/span><\/i><span style=\"font-weight: 400;\">\u3001<\/span><i><span style=\"font-weight: 400;\">PINK1<\/span><\/i><span style=\"font-weight: 400;\">\u3001<\/span><i><span style=\"font-weight: 400;\">DJ-1<\/span><\/i><span style=\"font-weight: 400;\">), \u4ee5\u53ca\u5176\u5b83\u7684\u4e00\u4e9b\u9700\u8981\u8fdb\u4e00\u6b65\u786e\u8ba4\u7684\u5019\u9009\u57fa\u56e0\u3002\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u4e00\u4e2a\u91cd\u8981\u7684\u8fdb\u5c55\u662f\u9274\u5b9a\u51fa\u6548\u5e94\u91cf\u8981\u5c0f\u5f97\u591a\u7684\u9057\u4f20\u56e0\u7d20\uff0c\u8fd9\u4e9b\u9057\u4f20\u56e0\u7d20\u4f1a\u589e\u52a0\u60a3\u5e15\u91d1\u68ee\u75c5\u7684\u98ce\u9669\uff0c\u4f46\u672c\u8eab\u5e76\u4e0d\u662f\u81f4\u75c5\u56e0\u7d20\u3002\u5176\u4e2d\uff0c <\/span><i><span style=\"font-weight: 400;\">GBA <\/span><\/i><span style=\"font-weight: 400;\">\u57fa\u56e0\u4e2d\u7684\u7f55\u89c1\u75c5\u539f\u4f53\u53d8\u5f02\u5177\u6709\u6700\u5f3a\u7684\u5df2\u77e5\u98ce\u9669\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u5148\u524d\u53d1\u73b0\u5177\u6709\u7f55\u89c1\u7684\u6709\u5bb3\u7a81\u53d8\u65f6\u4f1a<\/span><i><span style=\"font-weight: 400;\">\u5bfc\u81f4<\/span><\/i><span style=\"font-weight: 400;\">\u5e15\u91d1\u68ee\u75c5\u7684\u57fa\u56e0\u4e2d\u4e5f\u53d1\u73b0\u4e86\u589e\u52a0PD\u98ce\u9669\u7684\u5e38\u89c1\u9057\u4f20\u53d8\u5f02\u2014\u2014\u6700\u7a81\u51fa\u7684\u4f8b\u5b50\u662f\u03b1\u7a81\u89e6\u6838\u86cb\u767d\u57fa\u56e0\u3002\u6b64\u540e\uff0c\u8be5\u9886\u57df\u7684\u7814\u7a76\u5df2\u4ece\u8bc4\u4f30\u5355\u57fa\u56e0\u98ce\u9669\u53d8\u4f53\u8f6c\u53d8\u4e3a\u5efa\u7acb\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206\uff0c\u6700\u8fd1\u7684\u8bc4\u4f30\u6db5\u76d6\u4e86\u8fd12,000\u4e2a\u4e2a\u4f53\u9057\u4f20\u53d8\u4f53\uff0c\u53ef\u7528\u4e8e\u5c06\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u5206\u4e3a\u4ece\u9ad8\u5230\u4f4e\u7684\u201c\u98ce\u9669\u56db\u5206\u4f4d\u6570\u201d \u9057\u4f20\u98ce\u9669\u4eba\u7fa4\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u76ee\u524d\u6240\u6709\u5df2\u77e5\u7684\u5e15\u91d1\u68ee\u81f4\u75c5\u57fa\u56e0\u5df2\u5728\u5168\u7403\u5404\u5730\u7684\u4e0d\u540c\u4eba\u7fa4\u4e2d\u53d1\u73b0\uff0c\u4f46\u662f\u5176\u4e2d\u4e00\u4e9bPD\u57fa\u56e0\u9ad8\u5ea6\u53d8\u5f02\u4e14\u5728\u4e0d\u540c\u7684\u4eba\u7fa4\u4e2d\u51fa\u73b0\u7684\u9891\u7387\u4e0d\u540c\u3002\u6700\u663e\u8457\u7684\u4f8b\u5b50\u662f<\/span><i><span style=\"font-weight: 400;\">LRRK2 <\/span><\/i><span style=\"font-weight: 400;\"> 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400;\">\u4f46\u4ecd\u6709\u5f88\u591a\u95ee\u9898\u6ca1\u6709\u5f97\u4ee5\u89e3\u51b3\u3002\u6211\u89c9\u5f97\u6700\u6709\u610f\u601d\u7684\u4e00\u4e2a\u95ee\u9898\u5c31\u662f\u5916\u663e\u7387\u51cf\u5c11\u7684\u73b0\u8c61\u3002\u5f88\u591a\u6587\u732e\u90fd\u8bb0\u5f55\u4e86\u8fd9\u4e00\u73b0\u8c61\uff0c\u7279\u522b\u662f\u5728\u663e\u6027\u9057\u4f20\u7684PD\u4e2d\uff0c\u4e00\u5c0f\u90e8\u5206\u7a81\u53d8\u643a\u5e26\u8005\u4ecd\u7136\u6ca1\u6709\u8fd9\u79cd\u75be\u75c5\uff0c\u6216\u8005\u53ea\u5728\u751f\u547d\u63a5\u8fd1\u5c3e\u58f0\u65f6\u624d\u53d1\u5c55\u51fa\u7b2c\u4e00\u4e2a\u4f53\u5f81\u3002\u9610\u660e\u5e76\u5c3d\u53ef\u80fd\u589e\u5f3a\u5185\u6e90\u6027\u75be\u75c5\u4fdd\u62a4\u7684\u6b64\u7c7b\uff08\u9057\u4f20\uff09\u56e0\u7d20\uff0c\u662f\u672a\u6765\u51e0\u5e74PD\u9886\u57df\u7684\u53c8\u4e00\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u673a\u9047\uff0cGP2\u4e3a\u6b64\u63d0\u4f9b\u4e86\u7406\u60f3\u7684\u7814\u7a76\u73af\u5883\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Christine Klein\u7275\u5934\u8d1f\u8d23GP2\u5355\u57fa\u56e0\u67a2\u7ebd\u3002\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0cChristine\u5206\u4eab\u4e86\u5979\u662f\u5982\u4f55\u5bf9\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u5b66\u4ea7\u751f\u7684\u5174\u8da3\uff0c\u8fc4\u4eca\u4e3a\u6b62\u5df2\u7ecf\u53d1\u73b0\u4e86\u54ea\u4e9b\u57fa\u56e0\u4ee5\u53ca\u5c1a\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n","protected":false},"author":0,"featured_media":50019548,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50011825","post","type-post","status-publish","format-standard","hentry","post-type-728","post-type-2435","topic-2049"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50011825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/comments?post=50011825"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/posts\/50011825\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media\/50019548"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/zh-hans\/wp-json\/wp\/v2\/media?parent=50011825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}