{"id":50012047,"date":"2023-08-25T20:35:41","date_gmt":"2023-08-26T00:35:41","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/%e5%85%b1%e5%90%8c%e7%9a%84%e3%82%b5%e3%82%a4%e3%82%a8%e3%83%b3%e3%82%b9%e3%81%8cgba1%e3%81%ae%e7%99%ba%e8%a6%8b%e3%82%92%e8%a7%a3%e3%81%8d%e6%94%be%e3%81%a4\/"},"modified":"2024-11-26T14:07:46","modified_gmt":"2024-11-26T19:07:46","slug":"%e5%85%b1%e5%90%8c%e7%9a%84%e3%82%b5%e3%82%a4%e3%82%a8%e3%83%b3%e3%82%b9%e3%81%8cgba1%e3%81%ae%e7%99%ba%e8%a6%8b%e3%82%92%e8%a7%a3%e3%81%8d%e6%94%be%e3%81%a4","status":"publish","type":"post","link":"https:\/\/gp2.org\/ja\/%e5%85%b1%e5%90%8c%e7%9a%84%e3%82%b5%e3%82%a4%e3%82%a8%e3%83%b3%e3%82%b9%e3%81%8cgba1%e3%81%ae%e7%99%ba%e8%a6%8b%e3%82%92%e8%a7%a3%e3%81%8d%e6%94%be%e3%81%a4\/","title":{"rendered":"\u5171\u540c\u7684\u30b5\u30a4\u30a8\u30f3\u30b9\u304cGBA1\u306e\u767a\u898b\u3092\u89e3\u304d\u653e\u3064"},"content":{"rendered":"

\u30a2\u30d5\u30ea\u30ab\u7cfb\u7956\u5148\u3092\u3082\u3064\u4eba\u3005\u306e\u65b0\u3057\u3044PD\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u95a2\u3059\u308b\u521d\u3081\u3066\u306e\u5927\u898f\u6a21\u306a\u767a\u898b\u306f\u3001\u3053\u308c\u307e\u3067\u3042\u307e\u308a\u7814\u7a76\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305f\u4eba\u53e3\u7fa4\u3092\u542b\u3081\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/h2>\n

\u30a2\u30d5\u30ea\u30ab\u7cfb\u306e\u7956\u5148\u3092\u6301\u3064\u4eba\u3005\u306b\u7279\u6709\u306e\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5 (PD) \u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u304c\u521d\u3081\u3066\u767a\u898b\u3055\u308c\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u5206\u91ce\u304c\u65b0\u305f\u306b\u958b\u62d3\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u4eca\u3001\u3053\u306e\u5206\u91ce\u306b\u304a\u3044\u3066\u75be\u75c5\u30ea\u30b9\u30af\u3084\u75c5\u6c17\u9032\u884c\u306e\u907a\u4f1d\u7684\u57fa\u76e4\u306e\u5168\u4f53\u50cf\u89e3\u660e\u304c\u8fd1\u3065\u304d\u3064\u3064\u3042\u308a\u3001\u305d\u308c\u3089\u306e\u907a\u4f1d\u7684\u767a\u898b\u306f\u3001\u9577\u5e74\u3042\u307e\u308a\u7814\u7a76\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u5145\u5206\u306a\u6cbb\u7642\u3092\u53d7\u3051\u3089\u308c\u306a\u304b\u3063\u305f\u4eba\u3005\u306b\u6069\u6075\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/span>\u30b0\u30ed\u30fc\u30d0\u30eb\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u907a\u4f1d\u5b66\u30d7\u30ed\u30b0\u30e9\u30e0\uff08GP2\uff09<\/span><\/a>\u306f\u3001\u5305\u62ec\u7684\u3067\u5171\u540c\u7684\u306a\u7814\u7a76\u30e2\u30c7\u30eb\u3092\u901a\u3058\u3066\u3001\u3053\u306e\u3088\u3046\u306a\u5f71\u97ff\u529b\u306e\u3042\u308b\u767a\u898b\u3078\u3064\u306a\u304c\u308b\u9053\u3092\u5207\u308a\u958b\u3044\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\u3059\u3067\u306b\u3053\u308c\u307e\u3067\u3001<\/span>GBA1<\/span><\/i>\u907a\u4f1d\u5b50\u306b\u306f\u3001PD\u767a\u75c7\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u5909\u7570\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5909\u7570\u306f\u3001\u5317\u6b27\u304a\u3088\u3073\u30a2\u30b7\u30e5\u30b1\u30ca\u30fc\u30b8\u7cfb\u30e6\u30c0\u30e4\u4eba\u306e\u7956\u5148\u3092\u6301\u3064\u4eba\u3005\u306b\u6700\u3082\u9ad8\u3044\u983b\u5ea6\u3067\u898b\u3089\u308c\u307e\u3057\u305f\u3002GP2\u306f\u4eca\u65e5\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u304a\u3088\u3073\u30a2\u30d5\u30ea\u30ab\u7cfb\u6df7\u8840\u306e\u4eba\u3005\u306b\u7279\u6709\u306e\u65b0\u3057\u3044<\/span>GBA1<\/span><\/i>\u5909\u7570\u306e\u767a\u898b\u3092\u5831\u544a\u81f4\u3057\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u4f53\u306f\u3001\u30b3\u30d4\u30fc\u304c1\u3064\u3042\u308b\u5834\u5408PD\u767a\u75c7\u30ea\u30b9\u30af\u304c1.5\u500d\u3001\u5909\u7570\u4f53\u306e\u4e21\u65b9\u306e\u30b3\u30d4\u30fc\u304c\u53d7\u3051\u7d99\u304c\u308c\u3066\u3044\u308b\u5834\u5408\u306f\u30ea\u30b9\u30af\u304c3\uff5e4\u500d\u3068\u5927\u5e45\u306b\u5897\u52a0\u3057\u307e\u3059\u3002\u30ca\u30a4\u30b8\u30a7\u30ea\u30a2\u306ePD\u30b3\u30db\u30fc\u30c8\u3067\u3053\u306e\u5909\u7570\u306f\u4e00\u822c\u7684\u3067\u3059\u304c\u3001\u4e16\u754c\u306e\u4ed6\u306e\u5730\u57df\u3067\u306f\u4fe1\u3058\u3089\u308c\u306a\u3044\u307b\u3069\u5e0c\u5c11\u3067\u3042\u308b\u305f\u3081\u3001\u3053\u308c\u307e\u3067\u767a\u898b\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n

GP2\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/i><\/h4>\n

GP2\u306f\u3001Aligning Science Across Parkinson\u2019s\uff08ASAP\uff09\u306e\u6700\u521d\u306e\u30ea\u30bd\u30fc\u30b9\u30d7\u30ed\u30b0\u30e9\u30e0\u3068\u3057\u30662019\u5e74\u306b\u958b\u59cb\u3055\u308c\u307e\u3057\u305f\u3002GP2\u306e\u76ee\u7684\u306f\u3001\u4e16\u754c\u4e2d\u306e15\u4e07\u4eba\u3092\u8d85\u3048\u308b\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306e\u907a\u4f1d\u5b50\u578b\u3092\u89e3\u6790\u3057\u3066PD\u306e\u907a\u4f1d\u7684\u57fa\u790e\u306b\u3064\u3044\u3066\u7406\u89e3\u3092\u6df1\u3081\u3001\u305d\u306e\u77e5\u898b\u3092\u4e16\u754c\u7684\u306b\u95a2\u9023\u6027\u306e\u3042\u308b\u3082\u306e\u306b\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u30c7\u30fc\u30bf\u5b8c\u6210\u6642\u306b\u306f\u6700\u5927\u304b\u3064\u6700\u3082\u591a\u69d8\u306a\u7956\u5148\u304b\u3089\u306ePD\u30c7\u30fc\u30bf\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u4ed6\u306e\u75be\u60a3\u3068\u540c\u69d8\u3001\u73fe\u5728\u306ePD\u306b\u95a2\u3059\u308b\u77e5\u898b\u306f\u3053\u306e\u75be\u60a3\u306b\u82e6\u3057\u3080\u4eba\u3005\u306e\u591a\u69d8\u6027\u3092\u53cd\u6620\u3057\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u7406\u89e3\u306f\u4e0d\u5b8c\u5168\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u8a2d\u8a08\u306f\u3001\u4e0d\u8db3\u3059\u308b\u90e8\u5206\u3092\u610f\u56f3\u7684\u306b\u57cb\u3081\u3088\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u4e0d\u5b8c\u5168\u306a\u77e5\u898b\u306f\u3001\u6cbb\u7642\u306e\u683c\u5dee\u3060\u3051\u3067\u306a\u304f\u3001\u533b\u85ac\u54c1\u958b\u767a\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u8a2d\u8a08\u3084\u53c2\u52a0\u306b\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002<\/span><\/p>\n

\u00a0<\/span>\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u671f\u5f85\u3055\u308c\u308b\u306e\u306f\u3001\u7814\u7a76\u306e\u30b9\u30b3\u30fc\u30d7\u3068\u898f\u6a21\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u73fe\u5b9f\u306b\u3059\u308b\u305f\u3081\u306bGP2\u304c\u63a1\u7528\u3057\u305f\u6226\u7565\u3067\u3059\u3002\u30a2\u30f3\u30c9\u30ea\u30e5\u30fc\u30fb\u30b7\u30f3\u30b0\u30eb\u30c8\u30f3\u535a\u58eb\u3068\u30b3\u30fc\u30cd\u30ea\u30b9\u30fb\u30d6\u30e9\u30a6\u30a6\u30a7\u30f3\u30c9\u30e9\u30fc\u30c8\u535a\u58eb\u304c\u4e3b\u5c0e\u3057\u3001GP2\u304c\u767a\u898b\u306e\u30a8\u30f3\u30b8\u30f3\u30fb\u80fd\u529b\u7d44\u7e54\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u65b0\u305f\u306a\u7814\u7a76\u30cb\u30fc\u30ba\u3084\u8ab2\u984c\u306b\u8fc5\u901f\u304b\u3064\u52b9\u7387\u7684\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u30b9\u30ad\u30eb\u30bb\u30c3\u30c8\u3001\u30c4\u30fc\u30eb\u3001\u30a4\u30f3\u30d5\u30e9\u3092\u4e16\u754c\u7684\u306a\u7814\u7a76\u7d44\u7e54\u306b\u63d0\u4f9b\u3059\u308b\u3068\u3044\u3046\u5b9f\u7528\u7684\u306a\u672a\u6765\u56f3\u3092\u63cf\u304d\u307e\u3057\u305f\u3002GP2\u306b\u306f6\u5927\u9678\u306755\u3092\u8d85\u3048\u308b\u62e0\u70b9\u306b\u5354\u529b\u8005\u304c\u304a\u308a\u3001\u305d\u308c\u305e\u308c\u306e\u5834\u6240\u304b\u3089\u30b5\u30f3\u30d7\u30eb\u304c\u63d0\u4f9b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u904e\u53bb\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u6b86\u3069\uff08\u63a8\u5b9a\u7bc4\u56f2<\/span>86<\/span><\/a>\uff5e<\/span>96<\/span><\/a>%\uff09\u304c\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u306e\u4eba\u53e3\u7fa4\u3067\u884c\u308f\u308c\u3066\u304d\u305f\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u3053\u308c\u306f\u5927\u898f\u6a21\u306a\u4e8b\u696d\u3067\u3042\u308b\u3068\u540c\u6642\u306b\u3001\u6b63\u3057\u3044\u65b9\u5411\u3078\u9032\u3080\u305f\u3081\u306e\u91cd\u8981\u306a\u4e00\u6b69\u3067\u3059\u3002<\/span><\/p>\n

\u00a0<\/span>\u5b9f\u969b\u306e\u4e3b\u306a\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u306f\u4f55\u3067\u3059\u304b?\u30b3\u30db\u30fc\u30c8\u3092\u5171\u6709\u3059\u308b\u3001\u307e\u305f\u306f\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u5c02\u9580\u77e5\u8b58\u3092\u63d0\u4f9b\u3059\u308b\u610f\u601d\u306e\u3042\u308b\u6709\u8cc7\u683c\u7814\u7a76\u8005\u3067\u3042\u308c\u3070\u8ab0\u3067\u3082GP2\u306b\u53c2\u52a0\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002GP2\u306f\u305d\u306e\u4e2d\u5fc3\u7d44\u7e54\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u3092\u751f\u6210\u3001\u5bfe\u5fdc\u3059\u308b\u81e8\u5e8a\u30c7\u30fc\u30bf\u3092\u8abf\u548c\u3055\u305b\u307e\u3059\u3002\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306f\u8ca2\u732e\u3057\u305f\u7814\u7a76\u8005\u306b\u623b\u3055\u308c\u3001GP2\u306e\u4e2d\u6838\u8a08\u7b97\u30ef\u30fc\u30af\u30b9\u30da\u30fc\u30b9\u306b\u30d7\u30c3\u30b7\u30e5\u3055\u308c\u307e\u3059\u3002GP2\u30e1\u30f3\u30d0\u30fc\u3067\u3042\u308c\u3070\u8ab0\u3067\u3082\u30c7\u30fc\u30bf\u5206\u6790\u3092\u63d0\u6848\u3057\u3001\u6280\u8853\u7684\u307e\u305f\u306f\u8a08\u7b97\u30b5\u30dd\u30fc\u30c8\u3092\u30ea\u30af\u30a8\u30b9\u30c8\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u6839\u62e0\u3068\u306a\u308b\u30c7\u30fc\u30bf\u3068\u3068\u3082\u306b\u4ed6\u306e\u7814\u7a76\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u3068\u5171\u6709\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n

\u632f\u308a\u8fd4\u308a\uff1a\u3053\u308c\u307e\u3067\u306e\u7d4c\u7def<\/i><\/b><\/h4>\n

GP2\u306e\u6700\u521d\u306e2\u5e74\u9593\u306f\u7d44\u7e54\u306e\u904b\u55b6\u3068\u80fd\u529b\u958b\u767a\u306b\u7126\u70b9\u3092\u5f53\u3066\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u306b59\u304b\u56fd\u304b\u3089147\u306e\u65e2\u5b58\u30b3\u30db\u30fc\u30c8\u3092\u7d50\u96c6\u3057\u3001\u53c2\u52a0\u8005\u306e\u540c\u610f\u3084\u30c7\u30fc\u30bf\u5171\u6709\u306e\u8a31\u53ef\u304c\u9069\u5207\u306b\u884c\u308f\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3001\u4e16\u754c\u4e2d\u306e\u3055\u307e\u3056\u307e\u306a\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u3067\u4fe1\u983c\u3092\u69cb\u7bc9\u3001\u305d\u3057\u3066\u4e2d\u6838\u3068\u306a\u308b\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u3092\u8a2d\u5b9a\u3057\u307e\u3057\u305f\u3002\u91cd\u8981\u306a\u306e\u306f\u3001GP2\u904b\u55b6\u5074\u306e\u4ee3\u8868\u8005\u306e\u5897\u52a0\u304b\u3089\u3001\u4f4e\u30fb\u4e2d\u6240\u5f97\u56fd\uff08LMIC\uff09\u3084\u7c73\u56fd\u306b\u304a\u3051\u308b\u3001\u3053\u308c\u307e\u3067\u3042\u307e\u308a\u7814\u7a76\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305f\u4eba\u53e3\u7fa4\u3078\u306e\u8cc7\u91d1\u96c6\u3081\u306e\u53d6\u308a\u7d44\u307f\u306b\u81f3\u308b\u307e\u3067\u3001\u4e16\u754c\u7684\u306a\u591a\u69d8\u6027\u3078\u306e\u53d6\u308a\u7d44\u307f\u304c\u790e\u3068\u3057\u3066\u3042\u3063\u305f\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n

\u00a0<\/span>\u6628\u5e74GP2\u306f\u3001\u904b\u7528\u3068\u30a4\u30f3\u30d5\u30e9\u304b\u3089\u3001\u30c7\u30fc\u30bf\u751f\u6210\u306b\u7126\u70b9\u3092\u79fb\u3057\u307e\u3057\u305f\u3002\u6700\u521d\u306e\u4e88\u5099\u5206\u6790\u306e1\u3064\u306f\u30ca\u30a4\u30b8\u30a7\u30ea\u30a2\u4eba\u30b3\u30db\u30fc\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u307e\u3057\u305f\u3002\u5f53\u6642\u306f\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u304f\uff081000 \u4ef6\u8fd1\u304f\u306e\u4e8b\u4f8b\uff09\u3001\u6210\u679c\u3078\u306e\u671f\u5f85\u304c\u4f4e\u304b\u3063\u305f\u305f\u3081\u3001\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u6a5f\u4f1a\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u65b0\u3057\u3044\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u56e0\u5b50\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306e\u5927\u898f\u6a21\u306a\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u53c2\u52a0\u8005\u6570\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u6570\u4e07\u4eba\u304b\u3089\u657010\u4e07\u4eba\u306b\u4e0a\u308a\u307e\u3059\u3002\u4eca\u56de\u306e\u7d50\u679c\u3067\u65b0\u305f\u306a\u30ea\u30b9\u30af\u5909\u7570\u7279\u5b9a\u306e\u53ef\u80fd\u6027\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u305f\u3081\u3001\u4fe1\u983c\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u518d\u5ea6\u5206\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u767a\u898b\u306f\u305d\u306e\u5f8c\u3001<\/span>BLAAC-PD<\/span><\/a>\uff08<\/span>\u9ed2<\/b>\u4eba\u30fb<\/span>\u30a2\u30d5\u30ea\u30ab\u7cfb<\/b><\/b>\u30a2\u30e1\u30ea\u30ab\u4eba<\/b>\u306e<\/span><\/b>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5<\/b>\u3068\u306e\u95a2\u4fc2\uff09\u306b\u53c2\u52a0\u3059\u308b\u4eba\u3005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u72ec\u7acb\u7814\u7a76\u3067\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002BLAAC-PD\u306f\u30a2\u30d5\u30ea\u30ab\u7cfb\u304a\u3088\u3073\u30a2\u30d5\u30ea\u30ab\u7cfb\u6df7\u8840\u306e\u7956\u5148\u3092\u6301\u3064\u4eba\u3005\u5bfe\u8c61\u3068\u3057\u305f\u3001\u7c73\u56fd\u5185\u306b\u304a\u3051\u308bGP2\u304c\u652f\u63f4\u3059\u308b\u6d3b\u52d5\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u3053\u306e\u30ea\u30b9\u30af\u5909\u7570\u304c\u897f\u30a2\u30d5\u30ea\u30ab\u3092\u8d85\u3048\u3066\u30a2\u30d5\u30ea\u30ab\u306e\u4eba\u53e3\u5168\u4f53\u306b\u62e1\u5927\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\u5f71\u97ff\u3001\u672a\u89e3\u6c7a\u306e\u8ab2\u984c\u3001\u65b0\u305f\u306a\u591c\u660e\u3051<\/i><\/b><\/h4>\n

\u3053\u306e\u767a\u898b<\/span><\/a>\u306f\u3001\u4eba\u9593\u306e\u5065\u5eb7\u5897\u9032\u306b\u5411\u3051\u305f\u57fa\u790e\u77e5\u8b58\u306e\u8ffd\u6c42\u306b\u304a\u3051\u308b\u5305\u62ec\u7684\u306a\u79d1\u5b66\u3078\u306e\u71b1\u5fc3\u306a\u53d6\u308a\u7d44\u307f\u304c\u5909\u9769\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002\u767a\u898b\u306f\u4e88\u60f3\u5916\u3067\u3057\u305f\u304c\u3001GP2\u306f\u3053\u306e\u3088\u3046\u306a\u6d1e\u5bdf\u3092\u5f97\u308b\u305f\u3081\u306e\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u3068\u30a4\u30f3\u30d5\u30e9\u3092\u69cb\u7bc9\u3057\u307e\u3057\u305f\u3002\u4e16\u754c\u5168\u4f53\u3067\u30a2\u30d5\u30ea\u30ab\u7cfb\u7956\u5148\u3092\u6301\u3064\u4eba\u3005\u306e\u4eba\u53e3\u306f\u7d0418\uff05\u3067\u3059\u304c\u3001\u5927\u898f\u6a21\u306a\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u304a\u3044\u3066\u30a2\u30d5\u30ea\u30ab\u7cfb\u7956\u5148\u3092\u6301\u3064\u4eba\u3005\u304c\u5bfe\u8c61\u306b\u542b\u307e\u308c\u308b\u306e\u306f\u7d042\uff05\u306e\u307f\u3067\u3059 [<\/span>Sirugo et al., Cell 2019<\/span><\/a>]\u3002\u307e\u305f\u3001PD\u306f\u30a2\u30d5\u30ea\u30ab\u4eba\u304a\u3088\u3073\u30a2\u30d5\u30ea\u30ab\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u7f79\u60a3\u304c\u5c11\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\uff08Bailey et al, 2020, Okubadejo 2007\uff09\u304c\u3001\u3053\u308c\u3089\u306e\u4eba\u53e3\u7fa4\u3092\u542b\u3081\u305f\u7814\u7a76\u304c\u307b\u3068\u3093\u3069\u5b58\u5728\u305b\u305a\u3001\u77db\u76fe\u3059\u308b\u5831\u544a\u304c\u3057\u3070\u3057\u3070\u3042\u308b\u305f\u3081\u3001\u3053\u306e\u8003\u3048\u65b9\u306f\u7269\u8b70\u3092\u91b8\u3057\u3066\u3044\u307e\u3059\u3002\u00a0<\/span><\/p>\n

\u79c1\u81ea\u8eab\u3001\u30ca\u30a4\u30b8\u30a7\u30ea\u30a2\u7cfb\u7956\u5148\u3092\u6301\u3064\u9ed2\u4eba\u5973\u6027\u3068\u3057\u3066\u3001\u3053\u306e\u767a\u898b\u306f\u975e\u5e38\u306b\u5171\u611f\u3067\u304d\u308b\u3082\u306e\u3067\u3057\u305f\u3002\u79c1\u81ea\u8eab\u304c\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u53c2\u52a0\u3057\u3066\u3044\u308b\u3068\u611f\u3058\u308b\u3053\u3068\u304c\u3042\u307e\u308a\u306a\u3044\u306e\u3067\u3001\u81ea\u5206\u306e\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u3068\u540c\u69d8\u306e\u7956\u5148\u3092\u6301\u3064\u3059\u3079\u3066\u306e\u4eba\u3005\u306b\u3068\u3063\u3066\u5b9f\u969b\u7684\u306a\u610f\u5473\u3092\u6301\u3064\u3053\u306e\u3088\u3046\u306a\u767a\u898b\u3092\u76ee\u306e\u5f53\u305f\u308a\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3066\u3001\u3068\u3066\u3082\u3046\u308c\u3057\u304f\u601d\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u30d9\u30fc\u30b9\u306e\u7cbe\u5bc6\u6cbb\u7642\u81e8\u5e8a\u8a66\u9a13\u304c\u3088\u308a\u4e00\u822c\u7684\u306b\u306a\u308b\u306b\u3042\u305f\u308a\u3001\u3053\u306eGP2\u306e\u767a\u898b\u3084\u305d\u306e\u4ed6\u306e\u75be\u60a3\u9818\u57df\u306b\u304a\u3051\u308b\u540c\u69d8\u306e\u767a\u898b (\u4f8b\uff1a\u30b0\u30eb\u30fc\u30d7\u9593\u306e\u6297\u304c\u3093\u5264\uff3b\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\uff3d\u4ee3\u8b1d\u306e\u9055\u3044\u3092\u4fc3\u9032\u3059\u308b<\/span>CYP2D6<\/span><\/i>\u5909\u7570 [<\/span>Popejoy & Fullerton. Nature 2016<\/span><\/a>]\u3001 \u30a2\u30d5\u30ea\u30ab\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u3092\u7814\u7a76\u306b\u542b\u3081\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u4fc3\u9032\u3055\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6a19\u7684\u6cbb\u7642\u6cd5 [<\/span>PCSK9<\/span><\/i>\u963b\u5bb3\u5264] \u306e\u9032\u6b69 [<\/span>Cohen et al., Nat Gen 2005<\/span><\/a>]\uff09\u304b\u3089\u3082\u660e\u3089\u304b\u306a\u3088\u3046\u306b\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u7814\u7a76\uff08GWAS\uff09\u306e\u767a\u898b\u306f\u7570\u306a\u308b\u6c11\u65cf\u9593\u3067\u518d\u73fe\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u5927\u898f\u6a21\u306a\u907a\u4f1d\u5b50\u7814\u7a76\u306e\u591a\u69d8\u6027\u3092\u62e1\u5927\u3059\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u3053\u306e\u767a\u898b\u306f\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u7956\u5148\u3092\u6301\u3064\u4eba\u3005\u306b\u65b0\u305f\u306a\u6cbb\u7642\u306e\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/span><\/p>\n

GBA1<\/span><\/i>\u304cPD\u306b\u3069\u306e\u3088\u3046\u306b\u5bc4\u4e0e\u3059\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u307e\u3060\u591a\u304f\u306e\u7591\u554f\u304c\u6b8b\u3063\u3066\u3044\u307e\u3059\u3002<\/span>GBA1<\/span><\/i>\u3092\u5bfe\u8c61\u3068\u3057\u305fSanofi\uff08Venglustat\uff09\u306b\u3088\u308b\u521d\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001<\/span>\u6cbb\u7642\u30b0\u30eb\u30fc\u30d7\u306e\u6210\u7e3e\u304c\u30d7\u30e9\u30bb\u30dc\u30b0\u30eb\u30fc\u30d7\u3088\u308a\u3082\u60aa\u304b\u3063\u305f<\/span><\/a>\u3053\u3068\u304b\u3089\u3001\u5b9f\u969b\u306e\u75be\u60a3\u30e1\u30ab\u30cb\u30ba\u30e0\u6a5f\u5e8f\u306e\u7406\u89e3\u304c\u4e0d\u5341\u5206\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u75be\u60a3\u306b\u95a2\u3059\u308b\u8ffd\u52a0\u306e<\/span>GBA1<\/span><\/i>\u5909\u7570\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u3067\u3001<\/span>GBA1<\/span><\/i>\u5909\u7570\u304c\u3069\u306e\u3088\u3046\u306b\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u304b\u306b\u95a2\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u3001\u75be\u60a3\u95a2\u9023\u7d4c\u8def\u306e\u6cbb\u7642\u6a19\u7684\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u5927\u5207\u306a\u306e\u306f\u3001\u4e16\u754c\u4e2d\u306e\u3055\u307e\u3056\u307e\u306a\u4eba\u53e3\u7fa4\u3067\u3053\u308c\u3089\u306e\u5909\u7570\u3092\u7814\u7a76\u3057\u3001<\/span>GBA1<\/span><\/i>\u6a19\u7684\u6cbb\u7642\u306e\u6069\u6075\u3092\u53d7\u3051\u3089\u308c\u308b\u60a3\u8005\u3092\u5897\u3084\u3059\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n

GP2\u304c\u767a\u898b\u30a8\u30f3\u30b8\u30f3\u3092\u52a0\u901f\u3057\u7d9a\u3051\u308b\u306b\u3064\u308c\u3066\u81e8\u5e8a\u8a66\u9a13\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5909\u308f\u308a\u3001PD\u306e\u907a\u4f1d\u5b50\u69cb\u9020\u306b\u95a2\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u308b\u591a\u304f\u306e\u767a\u898b\u304c\u4e16\u754c\u4e2d\u306b\u767a\u73fe\u3059\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002GP2\u304c\u69cb\u7bc9\u3057\u305f\u30a8\u30b3\u30b7\u30b9\u30c6\u30e0\u3001\u80fd\u529b\u3001\u57f9\u3063\u3066\u304d\u305f\u7814\u7a76\u8005\u306e\u9023\u643a\u3092\u632f\u308a\u8fd4\u308b\u6642\u3001\u5305\u62ec\u7684\u306a\u30b3\u30e9\u30dc\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u30b9\u30c8\u30fc\u30ea\u30fc\u304c\u305d\u3053\u306b\u3042\u308a\u307e\u3059\u3002\u8457\u8005\u306e\u7f72\u540d\u6b04\uff08\u30ca\u30a4\u30b8\u30a7\u30ea\u30a2\u306e24\u306e\u6a5f\u95a2\u3092\u4ee3\u8868\u3059\u308b78\u4eba\u306e\u8457\u8005\u3067\u69cb\u6210\uff09\u306f\u3001GP2\u30c1\u30fc\u30e0\u3001\u56fd\u969b\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u30b2\u30ce\u30df\u30af\u30b9\u30b3\u30f3\u30bd\u30fc\u30b7\u30a2\u30e0\uff08IPDGC\uff09\u30ca\u30a4\u30b8\u30a7\u30ea\u30a2\u652f\u90e8\u3001\u30de\u30a4\u30b1\u30eb\u30fbJ\u30fb\u30d5\u30a9\u30c3\u30af\u30b9\u8ca1\u56e3\u3001\u305d\u3057\u306623andMe\u306b\u3088\u308b\u5171\u540c\u7814\u7a76\u306e\u6210\u679c\u3092\u793a\u3059\u3082\u306e\u3067\u3059\u3002<\/span><\/p>\n

\u00a0<\/span>\u3053\u308c\u304b\u3089\u3082\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u6ce8\u76ee\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u3055\u3089\u306b\u591a\u304f\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u767b\u5834\u3057\u307e\u3059\uff01<\/span><\/p>\n

(\u514d\u8cac\uff1a\u3053\u306e\u767a\u898b\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u907a\u4f1d\u5b66\u306e\u7814\u7a76\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u30de\u30a4\u30eb\u30b9\u30c8\u30fc\u30f3\u3067\u3059\u304c\u3001\u3053\u306e\u767a\u898b\u304c\u5373\u6642\u306b\u6cbb\u7642\u306b\u5f71\u97ff\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306eFAQ\u3092\u304a\u8aad\u307f\u304f\u3060\u3055\u3044<\/a>\u3002\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u30a2\u30d5\u30ea\u30ab\u7cfb\u7956\u5148\u3092\u3082\u3064\u4eba\u3005\u306e\u65b0\u3057\u3044PD\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u95a2\u3059\u308b\u521d\u3081\u3066\u306e\u5927\u898f\u6a21\u306a\u767a\u898b\u306f\u3001\u3053\u308c\u307e\u3067\u3042\u307e\u308a\u7814\u7a76\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305f\u4eba\u53e3\u7fa4\u3092\u542b\u3081\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 \u30a2\u30d5\u30ea\u30ab\u7cfb\u306e\u7956\u5148\u3092\u6301\u3064\u4eba\u3005\u306b\u7279\u6709\u306e\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5 (PD) \u306e\u907a […]<\/p>\n","protected":false},"author":16,"featured_media":50024694,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50012047","post","type-post","status-publish","format-standard","hentry","post-type-gp2","post-type-753","post-type-717","post-type-741","topic-gp2-values-4","topic-research-collaboration-6"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/posts\/50012047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/comments?post=50012047"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/posts\/50012047\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/media\/50024694"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/media?parent=50012047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}