{"id":50011854,"date":"2021-05-24T20:26:04","date_gmt":"2021-05-25T00:26:04","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/gwas%e3%82%92%e7%90%86%e8%a7%a3%e3%81%99%e3%82%8b%ef%bc%9a%e3%83%91%e3%83%bc%e3%83%88%ef%bc%92%e3%80%80%e3%81%9d%e3%81%ae%e4%bb%96%e3%81%ae%e7%9f%a5%e8%a6%8b%e3%81%a8%e5%8a%a9%e8%a8%80\/"},"modified":"2024-10-21T15:04:48","modified_gmt":"2024-10-21T19:04:48","slug":"gwas%e3%82%92%e7%90%86%e8%a7%a3%e3%81%99%e3%82%8b%ef%bc%9a%e3%83%91%e3%83%bc%e3%83%88%ef%bc%92%e3%80%80%e3%81%9d%e3%81%ae%e4%bb%96%e3%81%ae%e7%9f%a5%e8%a6%8b%e3%81%a8%e5%8a%a9%e8%a8%80","status":"publish","type":"post","link":"https:\/\/gp2.org\/ja\/gwas%e3%82%92%e7%90%86%e8%a7%a3%e3%81%99%e3%82%8b%ef%bc%9a%e3%83%91%e3%83%bc%e3%83%88%ef%bc%92%e3%80%80%e3%81%9d%e3%81%ae%e4%bb%96%e3%81%ae%e7%9f%a5%e8%a6%8b%e3%81%a8%e5%8a%a9%e8%a8%80\/","title":{"rendered":"GWAS\u3092\u7406\u89e3\u3059\u308b\uff1a\u30d1\u30fc\u30c8\uff12\u3000\u305d\u306e\u4ed6\u306e\u77e5\u898b\u3068\u52a9\u8a00"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">\u524d\u56de\u306e<\/span><a href=\"https:\/\/gp2.org\/understanding-gwas\/\"><span style=\"font-weight: 400;\">\u30d6\u30ed\u30b0\u8a18\u4e8b<\/span><\/a><span style=\"font-weight: 400;\">\u3067\u306f\u3001GWAS\u306b\u3064\u3044\u3066\u3001\u7d71\u8a08\u7684\u624b\u6cd5\u3084\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3001\u6700\u65b0\u306e\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5GWAS\u306e\u4f8b\u306a\u3069\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u3001\u72ec\u81ea\u306eGWAS\u3092\u5b9f\u65bd\u3059\u308b\u305f\u3081\u306e\u8ffd\u52a0\u7684\u306a\u6d1e\u5bdf\u3068\u30d2\u30f3\u30c8\u3092\u63d0\u4f9b\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><b>\u54c1\u8cea\u7ba1\u7406\u304a\u3088\u3073\u30c7\u30fc\u30bf\u306e\u88dc\u5b8c<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"> \u9ad8\u54c1\u8cea\u306a\u907a\u4f1d\u5b50\u578b\uff08\u975e\u30d1\u30ea\u30f3\u30c9\u30ed\u30fc\u30e0\u6027\u3001\u3059\u306a\u308f\u3061A\/T\u304c\u306a\u304f\u3001\u53ef\u80fd\u3067\u3042\u308c\u3070G\/C\u304c\u3042\u308a\u3001\u30af\u30e9\u30b9\u30bf\u30fc\u306e\u54c1\u8cea\u3092\u793a\u3059\u30a4\u30eb\u30df\u30ca\u30b8\u30a7\u30f3\u30c8\u30ec\u30a4\u30f3\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\uff09\u3067\u3001\u6b20\u640d\u7387\u304c\u4f4e\u3044\u3067\u3059\uff08\u30b5\u30f3\u30d7\u30eb\u304a\u3088\u3073SNP\u3054\u3068\u306b1%\u672a\u6e80\u304c\u671b\u307e\u3057\u3044\uff09\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u4e00\u822c\u7684\u306b\u306f\u3001\u5171\u901a\u306e\u30de\u30a4\u30ca\u30fc\u30fb\u30a2\u30ec\u30eb\u983b\u5ea6\u304c1\uff05\u4ee5\u4e0a\u3067\u3042\u308b\u3053\u3068\u306b\u7740\u76ee\u3057\u307e\u3059\u304c\u3001\u305d\u308c\u4ee5\u4e0b\u306e\u5834\u5408\u306f\u3001\u907a\u4f1d\u5b50\u578b\u30af\u30e9\u30b9\u30bf\u304c\u975e\u5e38\u306b\u826f\u304f\u898b\u3048\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u307e\u3059\uff08\u691c\u67fb\u3059\u308b\u5fc5\u8981\u3042\u308a\uff09\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u30d8\u30c6\u30ed\u63a5\u5408\u6027\u306e\u9ad8\u3044\u30b5\u30f3\u30d7\u30eb\u306f\u3001\u6c5a\u67d3\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u3001\u30d8\u30c6\u30ed\u63a5\u5408\u7387\u304c\u4f4e\u3044\u5834\u5408\u3082\u554f\u984c\u3068\u306a\u308a\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u30b5\u30f3\u30d7\u30eb\u304c\u91cd\u8907\u3057\u3066\u3044\u305f\u308a\u4e0d\u53ef\u89e3\u306a\u5f62\u3067\u95a2\u9023\u3057\u3066\u3044\u308b\u30b5\u30f3\u30d7\u30eb\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306e\u89b3\u70b9\u304b\u3089\u30b5\u30f3\u30d7\u30eb\u306e\u907a\u4f1d\u7684\u7cfb\u7d71\u3092\u78ba\u8a8d\u3057\u3001\u89e3\u6790\u3057\u307e\u3059\uff08\u6211\u3005\u306f<\/span><a href=\"https:\/\/rajanil.github.io\/fastStructure\/\"><span style=\"font-weight: 400;\">fastStructure<\/span><\/a><span style=\"font-weight: 400;\">\u3068<\/span><a href=\"https:\/\/github.com\/gabraham\/flashpca\"><span style=\"font-weight: 400;\">flashPCA<\/span><\/a><span style=\"font-weight: 400;\">\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u4f7f\u7528\uff09\u3002\u591a\u69d8\u6027\u3092\u6700\u5927\u5316\u3059\u308b\u4e00\u65b9\u3067\u3001\u4eba\u53e3\u306e\u4e0b\u90e8\u69cb\u9020\u3068\u305d\u306e\u5206\u6790\u7d50\u679c\u3078\u306e\u5f71\u97ff\u306b\u6ce8\u610f\u3057\u307e\u3057\u3087\u3046\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u5bfe\u7167\u306e\u72b6\u614b\u3084\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u306b\u3088\u308b\u6b20\u5931\u306b\u3088\u308b\u30d0\u30a4\u30a2\u30b9\u3092\u542b\u3081\u3001\u5076\u7136\u3067\u306f\u6b20\u5931\u3057\u306a\u3044SNP\u3092\u8abf\u3079\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">1\u3064\u306e\u96c6\u56e3\u306b\u5bfe\u3057\u3066\u8907\u6570\u306e\u30a4\u30f3\u30d7\u30c6\u30fc\u30b7\u30e7\u30f3\u30fb\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9\u30fb\u30d1\u30cd\u30eb\u3092\u4f7f\u7528\u3057\u3001\u305d\u306e\u7d50\u679c\u5f97\u3089\u308c\u305f\u907a\u4f1d\u5b50\u578b\u306e\u4e2d\u3067\u6700\u3082\u54c1\u8cea\u306e\u9ad8\u3044\u6307\u6a19\u3092\u4f7f\u7528\u3067\u304d\u306a\u3044\u7406\u7531\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u308c\u306f\u3001\u6df7\u5408\u30b5\u30f3\u30d7\u30eb\u96c6\u56e3\u3067\u306f\u7279\u306b\u6709\u52b9\u3067\u3059\u3002<\/span><\/li>\n<\/ul>\n<p><b>\u7814\u7a76\u30ec\u30d9\u30eb\u306e\u5206\u6790\u306e\u30d2\u30f3\u30c8<\/b><b><\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u56de\u5e30-GWAS\u3067\u306f\u4e00\u822c\u7684\u306b\u3001\u9023\u7d9a\u3057\u305f\u6210\u679c\u306b\u306f\u7dda\u5f62\u56de\u5e30\u30e2\u30c7\u30eb\u3092\u3001\u96e2\u6563\u3057\u305f\u6210\u679c\u306b\u306f\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u3001\u5171\u5909\u91cf\u3092\u8003\u616e\u3057\u306a\u304c\u3089SNP\u3067\u306e\u30ea\u30b9\u30af\u3092\u5b9a\u91cf\u5316\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u69d8\u3005\u306a\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u30d1\u30c3\u30b1\u30fc\u30b8\u3092\u4f7f\u7528\u3057\u3066\u6df7\u5408\u7dda\u5f62\u30e2\u30c7\u30eb\u3092\u5b9f\u884c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u3053\u308c\u3089\u306e\u30e2\u30c7\u30eb\u306f\u8fd1\u7e01\u6027\u3084\u5fae\u7d30\u306a\u96c6\u56e3\u306e\u4e0b\u90e8\u69cb\u9020\u3092\u6b63\u78ba\u306b\u8aac\u660e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">PC &#8211; \u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u3066\u4e3b\u6210\u5206\u8ca0\u8377\u3092\u8a08\u7b97\u3059\u308b\u3053\u3068\u3067\u3001\u56de\u5e30\u30e2\u30c7\u30eb\u306e\u5171\u5909\u91cf\u3068\u3057\u3066\u6709\u52b9\u306a\u30bb\u30c3\u30c8\u3092\u4f5c\u6210\u3057\u3001\u96c6\u56e3\u306e\u4e0b\u90e8\u69cb\u9020\u3092\u52b9\u679c\u7684\u306b\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/span><\/li>\n<\/ul>\n<p><b>\u305d\u308c\u3067\u306f\u30e1\u30bf\u5206\u6790\u3057\u307e\u3057\u3087\u3046\u3002<\/b><b><\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u56fa\u5b9a vs. \u30e9\u30f3\u30c0\u30e0 &#8211; \u3053\u308c\u3089\u306f\u3001\u30c7\u30fc\u30bf\u30b5\u30a4\u30ed\u3084\u51fa\u7248\u7269\u3092\u307e\u305f\u3044\u3067\u3001\u30b5\u30de\u30ea\u30fc\u7d71\u8a08\u30ec\u30d9\u30eb\u3067\u30c7\u30fc\u30bf\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u30e1\u30bf\u5206\u6790\u624b\u6cd5\u3067\u3059\u3002\u56fa\u5b9a\u52b9\u679c\u30e1\u30bf\u5206\u6790\u306f\u30c7\u30a3\u30b9\u30ab\u30d0\u30ea\u30fc\u5206\u6790\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u591a\u304f\u3001\u4e00\u822c\u7684\u306b\u306f\u3088\u308a\u5f37\u529b\u3067\u3059\u304c\u3001\u30e9\u30f3\u30c0\u30e0\u52b9\u679c\u30e2\u30c7\u30eb\u306e\u65b9\u304c\u3088\u308a\u4fdd\u5b88\u7684\u3067\u3001\u30c7\u30fc\u30bf\u30b5\u30a4\u30ed\u9593\u306e\u7570\u8cea\u6027\u3092\u8003\u616e\u3067\u304d\u308b\u305f\u3081\u3001\u30e9\u30f3\u30c0\u30e0\u52b9\u679c\u30e2\u30c7\u30eb\u3092\u597d\u3080\u4eba\u3082\u3044\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u7570\u8cea\u6027\u306e\u63a8\u5b9a\u5024 &#8211; Cochrane&#8217;s Q \u3084 I2 \u3067\u8868\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u5916\u308c\u5024\u52b9\u679c\u306e\u504f\u308a\u3084\u7d50\u679c\u306e\u4e00\u822c\u5316\u3092\u77e5\u308b\u4e0a\u3067\u3001\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002<\/span><\/li>\n<\/ul>\n<p><b>\u7cbe\u67fb\u306e\u7d50\u679c<\/b><b><\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u30b9\u30bf\u30c7\u30a3\u30ec\u30d9\u30eb\u30e9\u30e0\u30c0 &#8211; 0.95\u304b\u30891.05\u306e\u9593\u3067\u7dad\u6301\u3057\u3001\u305d\u308c\u4ee5\u5916\u306f\u554f\u984c\u3067\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u30e9\u30e0\u30c0\u5168\u4f53\u304a\u3088\u3073\u30e9\u30e0\u30c01000 &#8211; \u7814\u7a76\u30ec\u30d9\u30eb\u307e\u305f\u306f\u30e1\u30bf\u5206\u6790\u30ec\u30d9\u30eb\u3067\u306e\u30e9\u30e0\u30c0\u306e\u8a08\u7b97\u306f\u3001\u75c7\u4f8b\u304c\u3042\u308b\u5834\u5408\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u4e0d\u5747\u8861\u306e\u90fd\u5408\u4e0a\u5384\u4ecb\u3067\u3059\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u6570\u304c\u975e\u5e38\u306b\u591a\u3044\u3068\u3001\u30e9\u30e0\u30c0\u7d71\u8a08\u304c\u4eba\u70ba\u7684\u306b\u5897\u5927\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5834\u5408\u30011000\u75c7\u4f8b\u30681000\u5bfe\u7167\u306b\u30b9\u30b1\u30fc\u30eb\u3055\u308c\u308b\u306e\u3067\u3001lambda1000\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002\u7e70\u308a\u8fd4\u3057\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u3053\u306e\u30b3\u30fc\u30c9\u306fGitHub\u306e\u30ec\u30dd\u306b\u3042\u308a\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Linkage disequilibrium (LD) \u30b9\u30b3\u30a2\u306e\u30a4\u30f3\u30bf\u30fc\u30bb\u30d7\u30c8 &#8211; \u30e9\u30e0\u30c0\u306e\u4ee3\u66ff\u54c1\/\u88dc\u5b8c\u54c1\u3067\u3001LD\u69cb\u9020\u3084\u75c7\u4f8b\u306b\u5bfe\u3057\u3066\u3088\u308a\u9811\u5f37\u3067\u3059\u3002\u3064\u307e\u308a\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u4e0d\u5747\u8861\u3067\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u5747\u4e00\u6027\u3092\u793a\u3059\u30d7\u30ed\u30c3\u30c8\u306eLD\u30d4\u30fc\u30af &#8211; \u3053\u308c\u306f\u975e\u5e38\u306b\u7c21\u5358\u306a\u3053\u3068\u3067\u3001\u30d7\u30ed\u30c3\u30c8\u3055\u308c\u305f\u7d50\u679c\u306f\u3001\u5439\u96ea\u3067\u306f\u306a\u304f\u3001\u30de\u30f3\u30cf\u30c3\u30bf\u30f3\uff08\u307e\u305f\u306f\u305d\u306e\u4ed6\u306e\u90fd\u5e02\u3001\u3054\u3081\u3093\u306a\u3055\u3044\u3001\u30ef\u30b7\u30f3\u30c8\u30f3D.C\uff09\u306e\u30bf\u30ef\u30fc\u306e\u3088\u3046\u306b\u898b\u3048\u308b\u306f\u305a\u3067\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u8907\u88fd &#8211; \u3042\u308b\u306b\u8d8a\u3057\u305f\u3053\u3068\u306f\u306a\u3044\u3067\u3059\u304c\u3001\u5229\u7528\u53ef\u80fd\u306a\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u304c\u306a\u3044\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u8ffd\u52a0\u30c7\u30fc\u30bf\u304c\u5165\u624b\u3067\u304d\u306a\u3044\u5834\u5408\u306f\u3001leave-one-out\u30e1\u30bf\u5206\u6790\u3068\u30af\u30ed\u30b9\u30d0\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/span><\/li>\n<\/ul>\n<p><b>GWAS\u5f8c\u306e\u5206\u6790<\/b><b><\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u3042\u308b\u3044\u306f\u300cGWAS\u30e1\u30bf\u5206\u6790\u304c\u5b8c\u4e86\u3057\u305f\u3089\u4f55\u3092\u3059\u3079\u304d\u304b\u300d\u3002\u306a\u304a\u3001GP2\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u30c6\u30fc\u30de\u306b\u95a2\u3059\u308b\u30d6\u30ed\u30b0\u8a18\u4e8b\u3084\u8b1b\u5ea7\u3092\u4eca\u5f8c\u3082\u63d0\u4f9b\u3057\u3066\u3044\u304f\u4e88\u5b9a\u3067\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u6761\u4ef6\u4ed8\u304d\u89e3\u6790 &#8211; \u5730\u57df\u3067\u6700\u3082\u91cd\u8981\u306aSNP\u3092\u5171\u5909\u6570\u3068\u3057\u3066\u4f7f\u7528\u3057\u3001\u89e3\u6790\u3092\u518d\u5b9f\u884c\u3059\u308b\u304b\u3001<\/span><a href=\"https:\/\/cnsgenomics.com\/software\/gcta\/#Overview\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GCTA<\/span><\/a><span style=\"font-weight: 400;\">\u306e\u3088\u3046\u306a\u30c4\u30fc\u30eb\u3092\u4f7f\u7528\u3059\u308b\u30021\u3064\u306e\u4f4d\u7f6e\u306b\u5bfe\u3057\u8907\u6570\u306e\u72ec\u7acb\u3057\u305f\u4fe1\u53f7\u304c\u3042\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u30d5\u30a1\u30a4\u30f3\u30de\u30c3\u30d4\u30f3\u30b0 &#8211; \u3053\u308c\u306f\u3001\u30d9\u30a4\u30ba\u30b3\u30ed\u30fc\u30ab\u30ea\u30bc\u30fc\u30b7\u30e7\u30f3\uff08\u907a\u4f1d\u5b50\u767a\u73fe\u307e\u305f\u306f\u540c\u69d8\u306e\u30e1\u30c8\u30ea\u30c3\u30af\u306e\u305f\u3081\u306e\u30b2\u30ce\u30e0\u53c2\u7167\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3059\u308b\uff09\u3092\u542b\u3080<\/span><a href=\"https:\/\/github.com\/chr1swallace\/coloc\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">coloc<\/span><\/a><span style=\"font-weight: 400;\">\u306e\u3088\u3046\u306a\u30d1\u30c3\u30b1\u30fc\u30b8\u3067\u8fd1\u4f3c\u30d9\u30a4\u30ba\u56e0\u5b50\u5206\u6790\u306b\u3088\u3063\u3066\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u4e88\u6e2c\u30a6\u30a7\u30a4\u30c8\u3068TWAS &#8211; \u907a\u4f1d\u5b50\u767a\u73fe\u3001\u30e1\u30c1\u30eb\u5316\u3001\u30af\u30ed\u30de\u30c1\u30f3\u7814\u7a76\u306a\u3069\u304b\u3089\u5f97\u3089\u308c\u305f\u5916\u90e8\u30a6\u30a7\u30a4\u30c8\u3092\u6d3b\u7528\u3057\u3066\u3001GWAS\u30c7\u30fc\u30bf\u306b\u96a0\u308c\u3066\u3044\u308b\u63a8\u5b9a\u4e0a\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306e\u69d8\u3005\u306a\u30d1\u30c3\u30b1\u30fc\u30b8\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ML &#8211; \u76ee\u7684\u306b\u5fdc\u3058\u305f\u4e88\u6e2c\u3001\u79c1\u305f\u3061\u306e\u6c17\u306b\u5165\u3063\u3066\u3044\u308b\u30d1\u30c3\u30b1\u30fc\u30b8\u306f<\/span><a href=\"https:\/\/genoml.github.io\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GenoML<\/span><\/a><span style=\"font-weight: 400;\">\u3067\u3059\u3002\u3068\u3044\u3046\u306e\u3082\u305d\u306e\u307b\u3068\u3093\u3069\u304c\u81ea\u52d5\u5316\u3055\u308c\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b66\u306b\u304a\u3051\u308b\u6a5f\u68b0\u5b66\u7fd2\uff08ML\uff09\u3092\u7c21\u5358\u306b\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3089\u3067\u3059\u3002<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u3001<\/span><a href=\"https:\/\/github.com\/GP2code\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GP2\u306eGitHub<\/span><\/a><span style=\"font-weight: 400;\">\u306b\u3042\u308b\u30b3\u30fc\u30c9\u3068\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/span><\/p>\n<p>\u3053\u306e\u30d6\u30ed\u30b0\u306fHampton Leonard\u3001Mike Nalls\u3001Yeajin Song\u3001Dan Vitale\u306b\u3088\u308a\u5171\u540c\u57f7\u7b46\u3055\u308c\u307e\u3057\u305f\u3002\u5f7c\u3089\u306e\u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u3001GP2\u306e\u96e3\u75c5 &#8211; \u30c7\u30fc\u30bf\u5206\u6790\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7<a href=\"\/working-groups\/complex-disease-data-analysis-working-group\/\">\u306e\u30da\u30fc\u30b8\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u524d\u56de\u306e\u30d6\u30ed\u30b0\u8a18\u4e8b\u300cGWAS\u3092\u7406\u89e3\u3059\u308b\u300d\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u3068\u3057\u3066\u3001GP2\u8907\u5408\u75be\u60a3\u30c7\u30fc\u30bf\u89e3\u6790\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u72ec\u81ea\u306eGWAS\u3092\u5b9f\u884c\u3059\u308b\u305f\u3081\u306e\u5b9f\u8df5\u7684\u306a\u30d2\u30f3\u30c8\u3068\u898b\u8b58\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"author":0,"featured_media":50019563,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-50011854","post","type-post","status-publish","format-standard","hentry","post-type-720","topic-complex-disease-genetics-3"],"acf":[],"_links":{"self":[{"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/posts\/50011854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/comments?post=50011854"}],"version-history":[{"count":0,"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/posts\/50011854\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/media\/50019563"}],"wp:attachment":[{"href":"https:\/\/gp2.org\/ja\/wp-json\/wp\/v2\/media?parent=50011854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}