{"id":50011818,"date":"2021-01-14T19:35:47","date_gmt":"2021-01-15T00:35:47","guid":{"rendered":"https:\/\/gp2stg.wpenginepowered.com\/gwas%e3%82%92%e7%90%86%e8%a7%a3%e3%81%99%e3%82%8b\/"},"modified":"2024-10-21T15:00:11","modified_gmt":"2024-10-21T19:00:11","slug":"gwas%e3%82%92%e7%90%86%e8%a7%a3%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/gp2.org\/ja\/gwas%e3%82%92%e7%90%86%e8%a7%a3%e3%81%99%e3%82%8b\/","title":{"rendered":"GWAS\u3092\u7406\u89e3\u3059\u308b"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">GWAS\u3092\u7406\u89e3\u3059\u308b\u2026\u305d\u3057\u3066\u4e00\u4f53\u306a\u305c\u30aa\u30c3\u30ba\u6bd4\u304c\u3053\u3093\u306a\u306b\u5c0f\u3055\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<br \/>\n\u4ee5\u4e0b\u306e\u8aac\u660e\u306f\u3001GWAS\u7814\u7a76\u3092\u975e\u5e38\u306b\u5358\u7d14\u306b\u8868\u73fe\u3057\u3066\u304a\u308a\u3001\u597d\u610f\u7684\u306a\u76ae\u8089\u3082\u542b\u3093\u3067\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u306b\u3088\u3063\u3066\u3001\u75c5\u6c17\u306b\u3064\u3044\u3066\u4f55\u304c\u5206\u304b\u308a\u307e\u3059\u304b\uff1f\u306a\u305c\u30b2\u30ce\u30e0\u306e100\u4e07\u3092\u8d85\u3048\u308b\u72ec\u7acb\u6a5f\u80fd\u3092\u30c6\u30b9\u30c8\u3057\u3001\u6df1\u523b\u306a\u591a\u91cd\u691c\u5b9a\u306e\u4e71\u7528\u306b\u8010\u3048\u308b\u306e\u3067\u3059\u304b\uff1f\u7b54\u3048\u306f\u975e\u5e38\u306b\u5358\u7d14\u3067\u3059\u30022\u3064\u306e\u975e\u5e38\u306b\u5358\u7d14\u306a\u7406\u7531\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305a\u3001\u907a\u4f1d\u5b50\u306e\u3059\u3079\u3066\u306e\u5019\u88dc\u95a2\u9023\u9818\u57df\uff08\u5225\u540d\u907a\u4f1d\u5b50\u5ea7\uff09\u306f\u3001\u75be\u60a3\u306b\u95a2\u3059\u308b\u77e5\u8b58\u306e\u7bc4\u56f2\u3092\u5e83\u3052\u307e\u3059\u3002\u7b2c2\u306b\u3001\u89b3\u5bdf\u3055\u308c\u308b\u3053\u308c\u3089\u306e\u7d2f\u7a4d\u7684\u306b\u5c0f\u3055\u306a\u5f71\u97ff\u306e\u3059\u3079\u3066\u306f\u3001\u305d\u308c\u305e\u308c\u304c\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306e\u308f\u305a\u304b\u306a\u5897\u52a0\u3092\u3082\u305f\u3089\u3057\u3001\u30ea\u30b9\u30af\u3092\u3088\u308a\u3088\u304f\u4e88\u6e2c\u3057\u3001\u8a3a\u65ad\u57fa\u6e96\u3092\u6d17\u7df4\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002GWAS\u306b\u306f\u4eee\u8aac\u304c\u306a\u3044\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5b9f\u969b\u306f\u300c\u30b2\u30ce\u30e0\u5185\u306e\u5909\u7570\u7a2e\u307e\u305f\u306f\u5909\u7570\u7a2e\u7fa4\u304c\u4f55\u3089\u304b\u306e\u60aa\u5f71\u97ff\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u8a73\u7d30\u3092\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308b\u300d\u3068\u3044\u3046\u306e\u304c\u4eee\u8aac\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u6700\u3082\u57fa\u672c\u7684\u306a\u30ec\u30d9\u30eb\u3067\u306f\u3001GWAS\u306f\u4e00\u9023\u306e\u65b9\u7a0b\u5f0f\u3067\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u304c1\u5ea6\u306b1\u3064\u306e\u30b2\u30ce\u30e0\u5909\u7570\u7a2e\u3092\u8abf\u3079\u307e\u3059\u3002\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u30b3\u30f3\u30c6\u30af\u30b9\u30c8\u3067\u3053\u308c\u3092\u5206\u89e3\u3057\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\uff08\u306f\u3044\u306e\u5834\u5408\u306f1\u3001\u3044\u3044\u3048\u306e\u5834\u5408\u306f0\uff09 ~\u00a0 \u03b2<\/span><\/i><i><span style=\"font-weight: 400;\">0<\/span><\/i><i><span style=\"font-weight: 400;\"> + \u03b2<\/span><\/i><i><span style=\"font-weight: 400;\">1<\/span><\/i><i><span style=\"font-weight: 400;\">variant +\u00a0 \u03b2<\/span><\/i><i><span style=\"font-weight: 400;\">2<\/span><\/i><i><span style=\"font-weight: 400;\">sex + \u03b2<\/span><\/i><i><span style=\"font-weight: 400;\">3<\/span><\/i><i><span style=\"font-weight: 400;\">age + \u03b2<\/span><\/i><i><span style=\"font-weight: 400;\">4<\/span><\/i><i><span style=\"font-weight: 400;\">PC1 + \u03b2<\/span><\/i><i><span style=\"font-weight: 400;\">5<\/span><\/i><i><span style=\"font-weight: 400;\">PC2<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">\u7d71\u8a08\u306b\u7cbe\u901a\u3057\u3066\u3044\u308b\u65b9\u306b\u306f\u3001\u6a19\u6e96\u306eGWAS\u5f0f\u306f\u5358\u7d14\u306a\u91cd\u56de\u5e30\u5f0f\u3067\u3059\u3002\u3053\u306e\u7279\u5b9a\u306e\u65b9\u7a0b\u5f0f\u306f\u3001\u305d\u306e\u4eba\u306e\u30b2\u30ce\u30e0\u5185\u306e\u7279\u5b9a\u5909\u7570\u7a2e\u306e\u5b58\u5728\u3092\u4f7f\u3063\u3066\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u304b\u304b\u3063\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u4e88\u6e2c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u30c6\u30b9\u30c8\u3057\u3066\u3044\u307e\u3059\u3002\u30c6\u30b9\u30c8\u3055\u308c\u305f\u5909\u7570\u7a2e\u306b\u52a0\u3048\u3066\u3001\u6027\u5225\u3001\u5e74\u9f62\u3001\u500b\u4eba\u30ec\u30d9\u30eb\u306e\u907a\u4f1d\u7684\u7956\u5148\u3092\u8aac\u660e\u3059\u308b\u4e3b\u6210\u5206\u306a\u3069\u306e\u4ed6\u306e\u8981\u56e0\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u305d\u308c\u3067\u306f\u3001\u30aa\u30c3\u30ba\u6bd4\u3068\u30d9\u30fc\u30bf\u306b\u3064\u3044\u3066\u8a71\u3057\u307e\u3057\u3087\u3046\u3002\u4e0a\u8a18\u306e\u5f0f\u3067\u306f\u3001\u5909\u6570\u306e\u524d\u306e\u2018\u03b2<\/span><span style=\"font-weight: 400;\">n<\/span><span style=\"font-weight: 400;\">\u2019\u9805\u306f\u4fc2\u6570\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u4e88\u6e2c\u53ef\u80fd\u6027\u307e\u305f\u306f\u300c\u30ea\u30b9\u30af\u300d\u304c\u3001\u305d\u306e\u5909\u6570\u306b\u5fdc\u3058\u3066\u3069\u306e\u7a0b\u5ea6\u5897\u52a0\u307e\u305f\u306f\u6e1b\u5c11\u3059\u308b\u304b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002GWAS\u7a3f\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u5909\u7570\u7a2e\u52b9\u679c\u30b5\u30a4\u30ba\u304c\u30d9\u30fc\u30bf\u5024\u307e\u305f\u306f\u30aa\u30c3\u30ba\u6bd4\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u307e\u3059\u3002\u4e21\u65b9\u3092\u89e3\u91c8\u3059\u308b\u305f\u3081\u306e\u4f8b\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u3053\u308c\u307e\u3067\u306e\u6700\u65b0\u304b\u3064\u6700\u5927\u306ePDGWAS\uff08Nalls, 2019\uff09\u3067\u306f\u3001PD\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u65b0\u3057\u3044\u5909\u7570\u7a2e\u306e1\u3064\u306f\u3001\u7b2c2\u67d3\u8272\u4f53\u4e0a\u306e\u5909\u7570\u7a2ers76116224\u3067\u3059\u3002\u3053\u306e\u5909\u7570\u7a2e\u306b\u95a2\u9023\u4ed8\u3051\u3089\u308c\u3066\u3044\u308b\u30d9\u30fc\u30bf\u5024\u306f0.110\u3067\u3059\u3002\u30aa\u30c3\u30ba\u6bd4\u306f1.12\u3067\u3059\uff08\u4fe1\u983c\u533a\u9593\uff1a 1.08\u20131.16\uff09\u30021.08\u20131.16).\u30d9\u30fc\u30bf\u5024\u306f\u3001\u7d50\u679c\u306e\u30e6\u30cb\u30c3\u30c8\u3042\u305f\u308a\u306e\u5897\u52a0\u307e\u305f\u306f\u6e1b\u5c11\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\uff1a<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">rs76116224\u5909\u7570\u7a2e\u306e1\u3064\u306e\u30b3\u30d4\u30fc\u3067\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u30ea\u30b9\u30af\u304c0.110 * 1 = 0.110\u5897\u52a0\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">rs76116224\u5909\u7570\u7a2e\u306e2\u3064\u306e\u30b3\u30d4\u30fc\u3067\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u30ea\u30b9\u30af\u304c0.110 * 2 = 0.220\u5897\u52a0\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09\u306f\u30d9\u30fc\u30bf\u4fc2\u6570\u306e\u6307\u6570\u3067\u3059\u304c\u3001\u89e3\u91c8\u304c\u5c11\u3057\u7570\u306a\u308a\u307e\u3059\u30021\u3088\u308a\u5927\u304d\u3044OR\u306f\u7d50\u679c\u306e\u3088\u308a\u9ad8\u3044\u30aa\u30c3\u30ba\u306b\u95a2\u9023\u4ed8\u3051\u3089\u308c\u30011\u306eOR\u306f\u95a2\u9023\u4ed8\u3051\u304c\u306a\u3044\u3053\u3068\u3092\u610f\u5473\u3057\u30011\u672a\u6e80\u306eOR\u306f\u7d50\u679c\u306e\u3088\u308a\u4f4e\u3044\u30aa\u30c3\u30ba\u306b\u95a2\u9023\u4ed8\u3051\u3089\u308c\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001OR\u304c1.12\u306e\u5834\u5408\u3001\u5909\u7570\u7a2e\u30b3\u30d4\u30fc\u304c1\u5358\u4f4d\u5897\u52a0\u3059\u308b\u3068\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u306a\u308b\u30aa\u30c3\u30ba\u304c12\uff05\u5897\u52a0\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u00a0\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u3053\u308c\u3067\u65b9\u7a0b\u5f0f\u304c\u5b8c\u6210\u3057\u305f\u306e\u3067\u3001\u30c7\u30fc\u30bf\u5185\u306e\u3059\u3079\u3066\u306e\u5909\u7570\u7a2e\u306b\u3064\u3044\u3066\u65b9\u7a0b\u5f0f\u3092\u8a08\u7b97\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30c7\u30fc\u30bf\u306e\u51e6\u7406\u65b9\u6cd5\u306b\u3082\u3088\u308a\u307e\u3059\u304c\u3001\u7d0425,375,550\u56de\u3067\u3059\u3002\u5e78\u3044\u3001\u3053\u308c\u3089\u3059\u3079\u3066\u306e\u65b9\u7a0b\u5f0f\u3092\u5b9f\u884c\u3059\u308b\u512a\u308c\u305f\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 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src=\"https:\/\/gp2.org\/wp-content\/uploads\/2021\/01\/ER4gBzPXDffm4wp6OlNSBmrIJNscmuObeqQouq1D_qy0J-at88VTn9RzyC9Ebqzzbwtfch1YZwyXOSRLuRFvFoHtppSg0r8ayB4DqebVIXv9QUrwqhN3ek3O7yxIVpBRP0HkCrGa.jpg\" alt=\"\" width=\"1600\" height=\"671\" \/><\/span><\/p>\n<p><span style=\"font-weight: 400;\"><span data-sheets-value=\"{&quot;1&quot;:2,&quot;2&quot;:&quot;GWAS\u306e\u73fe\u5728\u306e\u300c\u30de\u30f3\u30cf\u30c3\u30bf\u30f3\u30d7\u30ed\u30c3\u30c8\u300d\uff08\u30de\u30f3\u30cf\u30c3\u30bf\u30f3\u306e\u30bf\u30ef\u30fc\u306b\u3061\u306a\u3093\u3067\u547d\u540d\uff09\u306f\u4e0a\u8a18\u306e\u3068\u304a\u308a\u3067\u3059\uff08Nalls et al., 2019\uff09\u3002&quot;}\" data-sheets-userformat=\"{&quot;2&quot;:4995,&quot;3&quot;:{&quot;1&quot;:0},&quot;4&quot;:{&quot;1&quot;:2,&quot;2&quot;:16776960},&quot;10&quot;:1,&quot;11&quot;:4,&quot;12&quot;:0,&quot;15&quot;:&quot;Arial&quot;}\">GWAS\u306e\u73fe\u5728\u306e\u300c\u30de\u30f3\u30cf\u30c3\u30bf\u30f3\u30d7\u30ed\u30c3\u30c8\u300d\uff08\u30de\u30f3\u30cf\u30c3\u30bf\u30f3\u306e\u30bf\u30ef\u30fc\u306b\u3061\u306a\u3093\u3067\u547d\u540d\uff09\u306f\u4e0a\u8a18\u306e\u3068\u304a\u308a\u3067\u3059\uff08Nalls et al., 2019\uff09<\/span>\u3002<\/span><a href=\"https:\/\/github.com\/ipdgc\/Manhattan-Plotter\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">\u3053\u3061\u3089<\/span><\/a><span style=\"font-weight: 400;\">\u3067\u30b3\u30fc\u30c9\u3092\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u30b3\u30fc\u30c9\u3068\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u306f<\/span><a href=\"https:\/\/github.com\/GP2code\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GP2 GitHub<\/span><\/a><span style=\"font-weight: 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